Results 11 to 20 of about 328,500 (323)
Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production [PDF]
Pharmaceuticals, 2022 Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-
Caroline Bayart +7 more
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Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination.
Giselle Pacifico Sartori +7 more
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Comparative pathogenomic analysis reveals a highly tetanus toxin-producing clade of Clostridium tetani isolates in Japan [PDF]
mSphere, 2023 Clostridium tetani is the etiological agent of the disease tetanus, resulting in various symptoms, including neck tension, tongue-twisting, a decline in walking ability, and death in severe cases. To date, publicly available genome sequences of C. tetani
Chie Shitada +6 more
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JAMA: The Journal of the American Medical Association, 1895 n ...
P. C. COLEMAN
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The structure of the tetanus toxin reveals pH-mediated domain dynamics. [PDF]
EMBO Rep, 2017 The tetanus neurotoxin (TeNT) is a highly potent toxin produced by Clostridium tetani that inhibits neurotransmission of inhibitory interneurons, causing spastic paralysis in the tetanus disease. TeNT differs from the other clostridial neurotoxins by its
Masuyer G, Conrad J, Stenmark P.
europepmc +2 more sources
Toxins, 2013 Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem. Here the toxin moves trans-synaptically into
Bjørnar Hassel
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The Fixation of Tetanus Toxin by Ganglioside [PDF]
Journal of General Microbiology, 1961 SUMMARY: The fixation of tetanus toxin by brain ganglioside has been confirmed. A method has been developed for assaying the toxin-fixing capacity of ganglioside in the analytical ultracentrifuge. Under appropriate conditions ganglioside will fix many times its own weight of toxin. Ganglioside preparations from brain contain at least three gangliosides;
W. E. van Heyningen, Pauline A. Miller
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SV2 mediates entry of tetanus neurotoxin into central neurons. [PDF]
PLoS Pathogens, 2010 Tetanus neurotoxin causes the disease tetanus, which is characterized by rigid paralysis. The toxin acts by inhibiting the release of neurotransmitters from inhibitory neurons in the spinal cord that innervate motor neurons and is unique among the ...
Felix L Yeh +6 more
doaj +5 more sources
The effect of tetanus toxin in the goldfish [PDF]
The Journal of Physiology, 1971 1. The effects of tetanus toxin have been investigated both on central nervous and peripheral neuromuscular systems of goldfish.2. Tetanus toxin kills goldfish when administered in minute doses. The lethal effect is temperature dependent. Unlike mammals, in which tetanus toxin produces spastic paralysis and convulsions, the tetanus‐intoxicated goldfish
Jared M. Diamond, Jane Mellanby
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Epilepsia Open, EarlyView., 2022 Abstract Epilepsy syndromes during the early years of life may be attributed to an acquired insult, such as hypoxic–ischemic injury, infection, status epilepticus, or brain trauma. These conditions are frequently modeled in experimental rodents to delineate mechanisms of epileptogenesis and investigate novel therapeutic strategies.
Anna‐Maria Katsarou +7 more
wiley +1 more source