Results 11 to 20 of about 15,945 (179)
Toxins, 2013 Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem. Here the toxin moves trans-synaptically into
Bjørnar Hassel
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A Novel High-Potency Tetanus Vaccine
mBio, 2020 Chemically inactivated tetanus toxoid (CITT) is clinically effective and widely used. However, CITT is a crude nonmalleable vaccine that contains hundreds of Clostridium tetani proteins, and the active component is present in variable and sometimes minor
Amanda Przedpelski +4 more
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Infection in a Geriatric Patient: Do Not Let Your Guard Off! [PDF]
Annals of Geriatric Medicine and Research, 2023 Tetanus is an infectious disease caused by Clostridium tetani toxin. Although easily preventable through vaccination, over 73,000 new infections and 35,000 deaths due to tetanus occurred worldwide in 2019, with higher rates in countries with healthcare ...
Alessandra Piscitelli +9 more
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Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin
Pharmaceuticals, 2021 Tetanus neurotoxin (TeNT) is a protein exotoxin produced by Clostridium tetani that causes the deadly spastic neuroparalysis of tetanus. It consists of a metalloprotease light chain and of a heavy chain linked via a disulphide bond.
Giulia Zanetti +5 more
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Studies on Tetanus Toxin and Toxoid IV. Interaction of Formaldehyde with Tetanus Toxin [PDF]
Australian Journal of Biological Sciences, 1969 The binding of formaldehyde with tetanus toxin under mild detoxificatIOn conditions (0 ·1M phosphate buffer, pH 7· 0, O· 005-0· 06M HCHO, 20-37°C) has been studied quantitatively by using [14C]formaldehyde. When detoxification was followed with time (0· 005M HCHO, 37°C) the toxin showed a characteristic immediate drop in lethality (~80%), followed by a
D J, Dawson, C M, Mauritzen
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International Journal of Emergency Medicine, 2021 Background Tetanus is a rare disease caused by Clostridium tetani, which produces tetanolysin and tetanospasmin. In 2018, there were only approximately ten tetanus cases reported in Indonesia.
Dzulfikar D. L. Hakim +6 more
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From Bacterial Poisons to Toxins: The Early Works of Pasteurians
Toxins, 2022 We review some of the precursor works of the Pasteurians in the field of bacterial toxins. The word “toxin” was coined in 1888 by Ludwig Brieger to qualify different types of poison released by bacteria.
Jean-Marc Cavaillon
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Эпидемиология и вакцинопрофилактика, 2022 Relevance. Diphtheria toxoid (DT) and tetanus toxoid (TT) manufacturing appears as many steps process. On every stage of proceeding vaccine the control of critical points is being provided.
E. I. Komarovskaya, O. V. Perelygyna
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Immunogenicity test of tetanus component in adsorbed vaccines by toxin binding inhibition test
Memorias do Instituto Oswaldo Cruz, 2002 Samples from 20 lots of diphtheria-tetanus (adult use dT) vaccine and from 20 lots of diphtheria-tetanus-pertussis (DTP) vaccine were used to standardize and validate the in vitro toxin binding inhibition (ToBI) test for the immunogenicity test of the ...
Denise Cristina Souza Matos +5 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and b2-glycoprotein I – its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
ALEKSANDRA B. INIĆ-KANADA +4 more
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