Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination.
Giselle Pacifico Sartori +7 more
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Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production [PDF]
Pharmaceuticals, 2022 Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-
Caroline Bayart +7 more
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Comparative pathogenomic analysis reveals a highly tetanus toxin-producing clade of Clostridium tetani isolates in Japan [PDF]
mSphere, 2023 Clostridium tetani is the etiological agent of the disease tetanus, resulting in various symptoms, including neck tension, tongue-twisting, a decline in walking ability, and death in severe cases. To date, publicly available genome sequences of C. tetani
Chie Shitada +6 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and β2-glycoprotein I - its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
Inić-Kanada Aleksandra B. +4 more
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An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo [PDF]
Toxicon: X, 2019 The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of the first examples of immunotherapy and remains the standard of care for cases
Eduardo Aliprandini +5 more
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The light chain of tetanus toxin bound to arginine-rich cell-penetrating peptide inhibits cortical reaction in mouse oocytes. [PDF]
Front Cell Dev Biol, 2023 Klinsky OG +5 more
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Botulinum toxin A for trismus in cephalic tetanus [PDF]
Arquivos de Neuro-Psiquiatria, 1994 Cephalic tetanus is a localized form of tetanus. As in generalized forms , trismus is a prominent feature of the disease, leading to considerable difficulty in feeding, swallowing of the saliva and mouth hygiene.
Luiz Augusto F. Andrade +1 more
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Characterization of a Highly Toxigenic Clostridium tetani Strain from a Calf’s Castration Site [PDF]
Veterinary SciencesBackground: This case report describes a calf that underwent castration at a Japanese livestock farm and subsequently died after developing clinical signs of tetanus, including muscle rigidity and difficulty standing.
Chie Shitada +5 more
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Dynamic multiday seizure cycles and evolving rhythms in a tetanus toxin rat model of epilepsy. [PDF]
Sci RepZarei Eskikand P +3 more
europepmc +3 more sources