SV2 mediates entry of tetanus neurotoxin into central neurons. [PDF]
PLoS Pathogens, 2010 Tetanus neurotoxin causes the disease tetanus, which is characterized by rigid paralysis. The toxin acts by inhibiting the release of neurotransmitters from inhibitory neurons in the spinal cord that innervate motor neurons and is unique among the ...
Felix L Yeh +6 more
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Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]
Osong Public Health and Research Perspectives, 2018 Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi +7 more
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Preparation of Tetanus toxoid for equine [PDF]
Journal of Veterinary Medical Research, 2010 Tetanus toxoid for equines has been prepared by cultivation of C. tetani into new synthetic medium for production of high potent tetanus toxin which gave high flocculation units [90 Lf (Limit of flocculation)], and high minimum lethal dose (MLD) (600,000)
H. A. EL-Helw +2 more
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The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonging survival time of mice with tetanus [PDF]
Veterinarski Glasnik, 2018 Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani.
Mujezinović Indira +2 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and β2-glycoprotein I - its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
Inić-Kanada Aleksandra B. +4 more
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The use of Soy hydrolysate for tetanus toxin production [PDF]
Veterinary Medical Journal - Giza, 2011 The present work was planned to develop a modified system for the growth of C. tetani and production of tetanus toxin, the system includes growth media that contain no meat or dairy by-products using non-animal based products.
Mahmoud M +3 more
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A Novel High-Potency Tetanus Vaccine
mBio, 2020 Chemically inactivated tetanus toxoid (CITT) is clinically effective and widely used. However, CITT is a crude nonmalleable vaccine that contains hundreds of Clostridium tetani proteins, and the active component is present in variable and sometimes minor
Amanda Przedpelski +4 more
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The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]
, 1992 The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Weller, U. +5 more
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Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]
, 1994 The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Weller, U. +7 more
core +1 more source
Noradrenaline release from permeabilized synaptosomes is inhibited by the light chain of tetanus toxin [PDF]
, 1992 Noradrenaline release from rat brain cortical synaptosomes permeabilized with streptolysin O can be triggered by μM concentrations of free Ca2+. This process was inhibited within minutes by tetanus toxin and its isolated light chain, but not by its heavy
Stecher, Brigitte +20 more
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