Toxins, 2013 Tetanus toxin, the product of Clostridium tetani, is the cause of tetanus symptoms. Tetanus toxin is taken up into terminals of lower motor neurons and transported axonally to the spinal cord and/or brainstem. Here the toxin moves trans-synaptically into
Bjørnar Hassel
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Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production [PDF]
Pharmaceuticals, 2022 Tetanus toxoid (TTd) plays an important role in the pharmaceutical world, especially in vaccines. The toxoid is obtained after formaldehyde treatment of the tetanus toxin. In parallel, current emphasis in the drug discovery field is put on producing well-
Caroline Bayart +7 more
doaj +3 more sources
Characterization and evaluation of the enzymatic activity of tetanus toxin submitted to cobalt-60 gamma radiation [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background Tetanus toxin blocks the release of the inhibitory neurotransmitters in the central nervous system and causes tetanus and its main form of prevention is through vaccination.
Giselle Pacifico Sartori +7 more
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Comparative pathogenomic analysis reveals a highly tetanus toxin-producing clade of Clostridium tetani isolates in Japan [PDF]
mSphere, 2023 Clostridium tetani is the etiological agent of the disease tetanus, resulting in various symptoms, including neck tension, tongue-twisting, a decline in walking ability, and death in severe cases. To date, publicly available genome sequences of C. tetani
Chie Shitada +6 more
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An oligoclonal combination of human monoclonal antibodies able to neutralize tetanus toxin in vivo [PDF]
Toxicon: X, 2019 The use of antibody-based therapy to treat a variety of diseases and conditions is well documented. The use of antibodies as an antidote to treat tetanus infections was one of the first examples of immunotherapy and remains the standard of care for cases
Eduardo Aliprandini +5 more
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An ELISA-Based Alternative to Mouse Bioassays for Quantitative Evaluation of Tetanus Toxin [PDF]
ToxinsTetanus toxin evaluation has traditionally relied on mouse LD50 bioassays, which require extensive animal use and time, necessitating development of alternative methods in accordance with 3R principles (Replacement, Reduction, and Refinement).
Chie Shitada +4 more
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Non-Wound Tetanus Mimicking Botulism in a Low-Resource Setting: Early Recognition and Successful Intensive Care Management [PDF]
International Medical Case Reports JournalAbdullahi Hassan Elmi, Ahmed Omar Abdi Department of Nursing and Midwifery, Dr. Sumait Hospital, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, SomaliaCorrespondence: Abdullahi Hassan Elmi, Email aarrkaa@simad.edu.soIntroduction ...
Elmi AH, Abdi AO
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Characterization of a Highly Toxigenic Clostridium tetani Strain from a Calf’s Castration Site [PDF]
Veterinary SciencesBackground: This case report describes a calf that underwent castration at a Japanese livestock farm and subsequently died after developing clinical signs of tetanus, including muscle rigidity and difficulty standing.
Chie Shitada +5 more
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The structure of the tetanus toxin reveals pH ‐mediated domain dynamics [PDF]
EMBO Reports, 2017 Geoffrey Masuyer +2 more
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Standardization of process for increased production of pure and potent tetanus toxin [PDF]
Journal of Microbiology and Infectious Diseases, 2013 Objectives: The aim of the study was to increase the yield of tetanus toxin in short time fermentor cultivation and also to produce pure and potent tetanus toxin replacing initial nitrogen source (N.Z Case) with papain digest broth in the modified ...
Chellamani Muniandi +3 more
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