Development and validation of a targeted LC-MS/MS quantitation method to monitor cell culture expression of tetanus neurotoxin during vaccine production [PDF]
Talanta vol. 236 (2022): 122883, 2022 The tetanus neurotoxin (TeNT) is one of the most toxic proteins known to man, which prior to the use of the vaccine against the TeNT producing bacteria Clostridium tetani, resulted in a 20 % mortality rate upon infection. The clinical detrimental effects of tetanus have decreased immensely since the introduction of global vaccination programs, which ...
arxiv +1 more source
Evaluation of Potency on Diphtheria and Tetanus Toxoid for Adult Vaccines by In Vivo Toxin Neutralization Assay Using National Reference Standards [PDF]
Osong Public Health and Research Perspectives, 2018 Objectives Vaccinations against diphtheria and tetanus are essential in providing immunity against these bacterial infections. The potency of diphtheria and tetanus toxoid vaccines can be measured using the in vivo toxin neutralization assay.
Chan Woong Choi +7 more
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The effect of haloperidol, aminooxyacetic acid and (-)-nuciferine on prolonging survival time of mice with tetanus [PDF]
Veterinarski Glasnik, 2018 Introduction. Tetanus, also known as lockjaw, is a very dangerous, infectious, acute, usually afebrile disease characterised by muscle spasms. The causative agent of the disease is the bacterium Clostridium tetani.
Mujezinović Indira +2 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and β2-glycoprotein I - its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
Inić-Kanada Aleksandra B. +4 more
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Studies on Tetanus Toxin and Toxoid IV. Interaction of Formaldehyde with Tetanus Toxin [PDF]
Australian Journal of Biological Sciences, 1969 The binding of formaldehyde with tetanus toxin under mild detoxificatIOn conditions (0 1M phosphate buffer, pH 7 0, O 005-0 06M HCHO, 20-37 C) has been studied quantitatively by using [14C]formaldehyde. When detoxification was followed with time (0 005M HCHO, 37 C) the toxin showed a characteristic immediate drop in lethality (~80%), followed by a
CM Mauritzen, DJ Dawson
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Infection in a Geriatric Patient: Do Not Let Your Guard Off! [PDF]
Annals of Geriatric Medicine and Research, 2023 Tetanus is an infectious disease caused by Clostridium tetani toxin. Although easily preventable through vaccination, over 73,000 new infections and 35,000 deaths due to tetanus occurred worldwide in 2019, with higher rates in countries with healthcare ...
Alessandra Piscitelli +9 more
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A Novel High-Potency Tetanus Vaccine
mBio, 2020 Chemically inactivated tetanus toxoid (CITT) is clinically effective and widely used. However, CITT is a crude nonmalleable vaccine that contains hundreds of Clostridium tetani proteins, and the active component is present in variable and sometimes minor
Amanda Przedpelski +4 more
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Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets
Journal of Neurochemistry, 2021 Tetanus is a deadly but preventable disease caused by a protein neurotoxin produced by Clostridium tetani. Spores of C. tetani may contaminate a necrotic wound and germinate into a vegetative bacterium that releases a toxin, termed tetanus neurotoxin ...
A. Megighian +4 more
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Functional characterization of the catalytic site of the tetanus toxin light chain using permeabilized adrenal chromaffin cells [PDF]
, 1993 The molecular events underlying the inhibition of exocytosis by tetanus toxin were investigated in permeabilized adrenal chromaffin cells. We found that replacement of amino acid residues within the putative zinc binding domain of the tetanus toxin light
Ahnert-Hilger +57 more
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The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings [PDF]
, 1992 The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland.
Ahnert-Hilger, G. +5 more
core +1 more source