Coexistence of Competing Microbial Strains under Twofold Environmental Variability and Demographic Fluctuations [PDF]
Microbial populations generally evolve in volatile environments, under conditions fluctuating between harsh and mild, e.g. as the result of sudden changes in toxin concentration or nutrient abundance. Environmental variability thus shapes the long-time population dynamics, notably by influencing the ability of different strains of microorganisms to ...
arxiv +1 more source
From Bacterial Poisons to Toxins: The Early Works of Pasteurians
We review some of the precursor works of the Pasteurians in the field of bacterial toxins. The word “toxin” was coined in 1888 by Ludwig Brieger to qualify different types of poison released by bacteria.
Jean-Marc Cavaillon
doaj +1 more source
Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G.+28 more
core +1 more source
Structural and functional substrates of tetanus toxin in an animal model of temporal lobe epilepsy
The effects of tetanus toxin (TeNT) both in the spinal cord, in clinical tetanus, and in the brain, in experimental focal epilepsy, suggest disruption of inhibitory synapses.
Alex S. Ferecskó+6 more
semanticscholar +1 more source
Introduction of Macromolecules into Bovine Adrenal Medullary Chromaffin Cells and Rat Pheochromocytoma Cells (PC12) by Permeabilization with Streptolysin O: Inhibitory Effect of Tetanus Toxin on Catecholamine Secretion [PDF]
Conditions are described for controlled plasma membrane permeabilization of rat pheochromocytoma cells (PC12) and cultured bovine adrenal chromaffin cells by Streptolysin O (SLO).
Ahnert-Hilger G.+29 more
core +1 more source
Background Tetanus is a rare disease caused by Clostridium tetani, which produces tetanolysin and tetanospasmin. In 2018, there were only approximately ten tetanus cases reported in Indonesia.
Dzulfikar D. L. Hakim+6 more
doaj +1 more source
Relevance. Diphtheria toxoid (DT) and tetanus toxoid (TT) manufacturing appears as many steps process. On every stage of proceeding vaccine the control of critical points is being provided.
E. I. Komarovskaya, O. V. Perelygyna
doaj +1 more source
Epileptic high-frequency network activity in a model of non-lesional temporal lobe epilepsy [PDF]
High-frequency cortical activity, particularly in the 250–600 Hz (fast ripple) band, has been implicated in playing a crucial role in epileptogenesis and seizure generation. Fast ripples are highly specific for the seizure initiation zone.
Cmejla, Roman+5 more
core +3 more sources
Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium. Exocytosis is compensated for by the reformation of vesicles at plasma membrane and endosomes.
arxiv +1 more source
The light chain but not the heavy chain of botulinum A toxin inhibits exocytosis from permeabilized adrenal chromaffin cells [PDF]
The heavy and light chains of botulinum A toxin were separated by anion exchange chromatography. Their intracellular actions were studied using bovine adrenal chromaffin cells permeabilized with streptolysin O.
Ahnert-Hilger, G.+4 more
core +1 more source