Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
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Immunogenicity test of tetanus component in adsorbed vaccines by toxin binding inhibition test
Memorias do Instituto Oswaldo Cruz, 2002 Samples from 20 lots of diphtheria-tetanus (adult use dT) vaccine and from 20 lots of diphtheria-tetanus-pertussis (DTP) vaccine were used to standardize and validate the in vitro toxin binding inhibition (ToBI) test for the immunogenicity test of the ...
Denise Cristina Souza Matos +5 more
doaj +1 more source
Regulation of neuronal excitability through pumilio-dependent control of a sodium channel gene [PDF]
, 2004 Dynamic changes in synaptic connectivity and strength, which occur during both embryonic development and learning, have the tendency to destabilize neural circuits.
Baines, Richard A. +3 more
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The monoclonal antibody 26 raised against tetanus toxoid also recognizes tetanus toxin and b2-glycoprotein I – its binding properties in vitro and potential applications [PDF]
Journal of the Serbian Chemical Society, 2009 A murine monoclonal IgG1 antibody, marked as MAb26, specific for tetanus toxoid has been immunochemically characterized. By performing enzyme-linked immunosorbent assays (ELISAs) and western blot analyses, it was demonstrated that MAb26 reacted with ...
ALEKSANDRA B. INIĆ-KANADA +4 more
doaj
A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015 [PDF]
, 2018 Background People who inject drugs (PWID) are at an increased risk of wound botulism, a potentially fatal acute paralytic illness. During the first 6 months of 2015, a large outbreak of wound botulism was confirmed among PWID in Scotland, which resulted ...
Amanda Weir +43 more
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Optimization of human TAT-Fab antibody expression and its bioactivity assay
浙江大学学报. 农业与生命科学版, 2007 In order to establish high effective expression system for human TAT-Fab antibody with protective activity, the induction conditions for the expression of TAT-Fab antibody in E.
WANG Qun +4 more
doaj +1 more source
, 2014 Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust +15 more
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Neurobiology of Disease, 2001 The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin
J. Mellanby, A.J. Milward
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Tetanus in Animals — Summary of Knowledge
Folia Veterinaria, 2020 Tetanus is a neurologic non-transmissible disease (often fatal) of humans and other animals with a worldwide occurrence. Clostridium tetani is the spore producing bacillus which causes the bacterial disease.
Malinovská Z., Čonková E., Váczi P.
doaj +1 more source
Severe pertussis infection in infants less than 6 months of age: clinical manifestations and molecular characterization [PDF]
, 2017 We conducted a study to determine the main traits of pertussis among unimmunized infants less than 6 months of age. From August 2012 to March 2015, 141 nasopharyngeal aspirates (NPAs) were collected from infants with respiratory symptoms attending 2
Buttinelli, Gabriele +12 more
core +1 more source