Results 51 to 60 of about 318,498 (273)
Veterinaria, 2013 Tetanus is a disease that occurs in humans and various animal species worldwide. Tetanus toxin, after binding itself to nerve structures in the spinal cord, blocking the release of inhibitory transmitors which results in predominance of excitatory ...
Indira Mujezinović +2 more
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More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines
Proteomes, 2019 Clostridium tetani is the etiological agent of tetanus, a life-threatening bacterial infection. The most efficient protection strategy against tetanus is a vaccination with the C.
Jens Möller +2 more
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Structural basis of tetanus toxin neutralization by native human monoclonal antibodies
Cell Reports, 2021 Summary: Four potent native human monoclonal antibodies (mAbs) targeting distinct epitopes on tetanus toxin (TeNT) are isolated with neutralization potency ranging from approximately 17 mg to 6 mg each that are equivalent to 250 IU of human anti-TeNT ...
Yueming Wang +18 more
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A genetic fusion GDNF-C fragment of tetanus toxin prolongs survival in a symptomatic mouse ALS model
Restorative Neurology and Neuroscience, 2008 Purpose: Amyotrophic Lateral Sclerosis (ALS) is a paralyzing disorder that kills individuals within three to five years of onset without any possibility for effective treatment. One proposed therapy has been the use of neurotrophic factors to inhibit the
Jesús Ciriza +9 more
semanticscholar +1 more source
Head and Neck Cancer Immunotherapy: Overcoming Limitations and Enhancing Efficacy
Cancer Science, EarlyView.ICI‐included therapies are standard for R/M HNSCC patients. In particular, neoadjuvant ICI therapy shows promising clinical results even in nontreated resectable HNSCC patients. In addition, cancer vaccine, immune cell‐based therapy, immunomodulation therapy, and TME targeting therapy may combine with ICI.
Hirofumi Shibata +8 more
wiley +1 more source
The Action of Tetanus Toxin in Frogs [PDF]
Journal of General Microbiology, 1961 SUMMARY: The development of tetanus intoxication in the frog is dependent on the environmental temperature being above about 15". The incubation period and time to death become shorter as the environmental temperature is raised. Cooling below about 15° prevents both the fixation of the toxin and its action after fixation but does not increase the speed
openaire +3 more sources
Cancer Science, EarlyView.Anti‐HPV vaccine activists claimed that aluminum (Al) adjuvants in HPV vaccines could cause immune abnormalities, leading to neurological diseases. We evaluated the cytokine and histology profiles following administrations of HPV vaccines and other viral vaccines containing adjuvants.
Reona Shiro +9 more
wiley +1 more source
Bacterial Toxins, Current Perspectives
Toxins, 2020 Toxins are the major pathogenicity factors produced by numerous bacteria involved in severe diseases in humans and animals. Certain pathogenic bacteria synthesize only one toxin which is responsible for all the symptoms and outcome of the disease.
Michel R. Popoff
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High-level Expression of Tetanus Toxin Fragment C in Escherichia coli [PDF]
Archives of Razi Institute, 2018 Fragment C is the C-terminal domain of the heavy chain of tetanus toxin that can promote the immune response against the lethal dose of this toxin. Therefore, this portion can be considered as a candidate vaccine against tetanus infection, which occurs ...
K. Aghaiypour, R. Teymourpour
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Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó +4 more
wiley +1 more source