Results 1 to 10 of about 23,011 (262)
Tetrahydrobiopterin and inherited hyperphenylalaninemias
The Turkish Journal of Pediatrics, 1996 Tetrahydrobiopterin deficiency, a variant of hyperphenylalaninemia, may be caused by deficiency of one of the following enzymes: guanosine triphosphate cyclohydrolase 1,6-pyruvoyltetrahydropterin synthase, dihydropteridin reductase and pterin-4a ...
N Blau, B Thony, M Spada, A Ponzone
doaj +3 more sources
Advances in the Microbial Synthesis of 5-Hydroxytryptophan
Frontiers in Bioengineering and Biotechnology, 2021 5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack
Xin-Xin Liu, Bin Zhang, Lian-Zhong Ai
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Hypertension, 2011 See related article, pp 287–294 Tetrahydrobiopterin (BH4), an essential cofactor for diverse cellular processes, is present in almost every cell or tissue of higher organisms. BH4 has well-defined functions in terms of enzymatic activities (BH4 is a crucial cofactor for the aromatic amino acid hydroxylases and all isoforms of nitric oxide synthase ...
Cynthia J. Meininger, Guoyao Wu
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Effect of phototherapy on event-related potentials in patients with post-stroke depression through serum tetrahydrobiopterin level intervention: a clinical study. [PDF]
BMC PsychiatryXie B +5 more
europepmc +3 more sources
Redox Biology, 2020 Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar +6 more
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Tetrahydrobiopterin and Cardiovascular Disease [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2006 Tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid hydroxylases, which are essential in the formation of neurotransmitters, and for nitric oxide synthase. It is presently used clinically to treat some forms of phenylketonuria (PKU) that can be ameliorated by BH 4
Moens, An, Kass, David A.
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Frontiers in Neuroscience, 2021 It has been well recognized that exposure to chronic stress could increase pain responding and exacerbate pain symptoms, resulting in stress-induced hyperalgesia. However, the mechanisms underlying stress-induced hyperalgesia are not yet fully elucidated.
Ying Huang +9 more
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Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]
, 2011 Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin +4 more
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Uncoupled nitric oxide synthase activity promotes colorectal cancer progression
Frontiers in Oncology, 2023 Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam +5 more
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Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria [PDF]
, 2017 Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.” Although prior research has identified biochemical and genotypic ...
Christ, Shawn E +5 more
core +4 more sources