Results 101 to 110 of about 26,569 (299)

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

open access: yesPteridines, 2002
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro   +6 more
doaj   +1 more source

Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain

open access: yesMicrobial Biotechnology, Volume 18, Issue 4, April 2025.
Yeast strain engineered for serotonin production. The medium and fermentation conditions have been optimised to achieve the highest serotonin production of any S. cerevisiae strain to date. ABSTRACT The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model.
Andrés Planells‐Cárcel   +5 more
wiley   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]

open access: yes, 2017
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau, Nenad   +3 more
core  

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications

open access: yesAdvanced Science, Volume 12, Issue 10, March 13, 2025.
BACH1, a basic leucine zipper protein ubiquitously expressed in mammalian tissues, plays a critical role in the regulation of oxidative stress, cell cycle progression, heme homeostasis, and immune responses. It is implicated in cardiovascular diseases, cancer progression, neurodegenerative disorders, and many other diseases.
Xiangxiang Wei   +9 more
wiley   +1 more source

Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism [PDF]

open access: yes, 2009
The average UK adult consumes less than three portions of fruit and vegetables daily, despite evidence to suggest that consuming five portions daily could help prevent chronic diseases. It is recommended that fruit juice should only count as one of these
George, Trevor   +4 more
core   +1 more source

Chemical structure of 1-O-(L-erythro-biopterin-2'-yl)-a-glucose isolated from a cyanobacterium Synechococcus sp. PCC 7942

open access: yesPteridines, 2001
A pteridine glycoside in Synechococcus sp. PCC 7942, the structure of which had been tentatively identified as biopterin-glucoside, was isolated and characterized for its exact chemical structure by 2D-NMR spectroscopy. The determined structure is 1-0-(L-
Choi Yong Kee   +3 more
doaj   +1 more source

Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder

open access: yesFrontiers in Pediatrics, 2014
Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited.
Richard Eugene Frye, Daniel eRossignol
doaj   +1 more source

Ferroptosis of T cell in inflammation and tumour immunity

open access: yesClinical and Translational Medicine, Volume 15, Issue 3, March 2025.
Ferroptosis‐related mechanisms significantly affect the biology of CD4+ T‐cell subsets and are further involved in inflammatory diseases. Crosstalk between CD8+ T cells and tumour cells induces ferroptosis in the tumour microenvironment. Glutathione peroxidase 4 loss promotes regulatory T‐cell ferroptosis to enhance anti‐tumour immunity.
Xueli Xia   +4 more
wiley   +1 more source

Investigation of the Relationship Between Serum Tetrahydrobiopterin and Folic Acid Levels with Each Other and with Preeclampsia in the Second and Third Trimesters

open access: yesVan Tıp Dergisi
INTRODUCTION: Aim: This study investigates the relationship between serum tetrahydrobiopterin (BH4) and folic acid levels in pregnant women during the second and third trimesters and the development of preeclampsia.
Mücahit Ahmet Aranlı   +4 more
doaj   +1 more source

Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells

open access: yesPteridines, 1997
We examined the inhibitory effect of tetrahydrobiopterin (BPH4) on L-β-(3,4-dihydroxyphenyl)alanine (DOPA)-induced cytotoxicity in PC-12 cells. First in vitro inhibitory efficacy of BPH4 on lipid peroxidation induced by Fe3+-DOPA complex was confirmed by
Kojima Shuji   +4 more
doaj   +1 more source

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