Results 101 to 110 of about 23,011 (262)

Living with phenylketonuria in adulthood: the PKU ATTITUDE study [PDF]

, 2018
Dietary treatment is the cornerstone of therapy for phenylketonuria (PKU), but adherence to low- phenylalanine diet progressively decreases after adolescence.
Bensi, Giulia, Biasucci, Giacomo, Burlina, Alberto, Cazzorla, Chiara, Leuzzi, Vincenzo, Manti, Filippo, Musumeci, Antonella, Papadia, Francesco, Polo, Giulia, Stoppioni, Vera, Tummolo, Albina, Vendemiale, Marcella   +11 more
core   +2 more sources

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

, 2022
Laurent Châtre, Aurélien Ducat, Frank T. Spradley, Ana C. Palei, Christiane Chéreau, Betty Couderc, Kamryn C. Thomas, Anna R. Wilson, Lorena M. Amaral, Irène Gaillard, Céline Méhats, Isabelle Lagoutte, Sébastien Jacques, Francisco Miralles, Frédéric Batteux, Joey P. Granger, Miria Ricchetti, Daniel Vaiman   +17 more
openalex   +1 more source

Early Levodopa Therapy in Tyrosine Hydroxylase Deficiency

Movement Disorders Clinical Practice, Volume 12, Issue 12, Page 2353-2356, December 2025.
Claudio M. de Gusmao, Roser Pons, Ganeshwaran H. Mochida, Laura Silveira‐Moriyama, Fernando Kok   +4 more
wiley   +1 more source

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 2002
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji   +6 more
doaj   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +5 more sources

Effect of Sepiapterin, 7,8-Dihydrobiopterin, 5,6,7,8-Tetrahydrobiopterin and Xanthopterin on Cholesterol and Phospholipid Content and Phospholipid Biosynthesis in vitro

Pteridines, 1995
Incorporation of fatty acids into phospholipids has been investigated using samples of rat live tissue homogenate, Krebs-Ringer-phosphate buffer (pH = 7A) containing 0.3% albumin, farry acid mixture and glycerol.
Rudzite Vera, Jurika Edite, Baier-Bitterlich Gabriele, Wachter Helmut, Fuchs Dietmar   +4 more
doaj   +1 more source

Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes

Antioxidants, 2019
Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four ...
Anish Engineer, Tana Saiyin, Elizabeth R. Greco, Qingping Feng   +3 more
doaj   +1 more source

Compensatory Feto-Placental Upregulation of the Nitric Oxide System during Fetal Growth Restriction [PDF]

, 2012
Background: Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Begliuomini, Silvia, Boldrini, Antonio, Casarosa, Elena, Coceani, Flavio, Fink, Bruno, Genazzani, Andrea R., Ghirri, Paolo, Pisaneschi, Silvia, Ripoli, Andrea, Sanchez, Angel Matias, Simoncini, Tommaso, Strigini, Francesca A. L.   +11 more
core   +3 more sources

Tetrahydrobiopterin, superoxide, and vascular dysfunction [PDF]

Free Radical Biology and Medicine, 2009
(6R)-5,6,7,8-Tetrahydrobiopterin (BH(4)) is an endogenously produced pterin that is found widely distributed in mammalian tissues. BH(4) works as a cofactor of aromatic amino acid hydroxylases and nitric oxide synthases. In the vasculature a deficit of BH(4) is implicated in the mechanisms of several diseases including atherosclerosis, hypertension ...
openaire   +2 more sources

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Clapp, BR, Deanfield, JE, Gallimore, JR, Hineorani, AD, Hirschfield, GM, MacAllister, RJ, Pepys, MB, Singer, M, Stidwill, RP, Storry, C, Vallance, P   +10 more
core   +1 more source