Results 21 to 30 of about 26,569 (299)

Biosynthesis of tetrahydrobiopterin in man [PDF]

Journal of Inherited Metabolic Disease, 1985
AbstractThe biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. The phosphate‐eliminating enzyme (PEE) was purified ~750‐fold. The conversion of NH2P3 to BH4 was catalyzed by this enzyme in the presence of partially purified sepiapterin reductase, Mg2+ and NADPH.
Curtius, Hans-Christoph, Heintel, Dorothee, Kuster, Thomas, Leimbacher, Walter, Niederwieser, Alois, Ghisla, Sandro   +5 more
openaire   +3 more sources

Kynurenine and Tetrahydrobiopterin Pathways Crosstalk in Pain Hypersensitivity

Frontiers in Neuroscience, 2020
Despite the identification of molecular mechanisms associated with pain persistence, no significant therapeutic improvements have been made. Advances in the understanding of the molecular mechanisms that induce pain hypersensitivity will allow the ...
Ananda Christina Staats Pires, V. Tan, B. Heng, G. Guillemin, A. Latini   +4 more
semanticscholar   +1 more source

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin, Kunuthur, S. P., Milliken, P. H., Suckling, C. J., Wadsworth, R. M.   +4 more
core   +1 more source

Response of Phenylketonuria to Tetrahydrobiopterin [PDF]

The Journal of Nutrition, 2007
A favorable response, indicated by decline of blood phenylalanine (Phe) in patients with phenylketonuria (PKU), to orally administered 6-R-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4) has been reported in many countries following the first publication in 1999. In this review, we describe the experience in the United States with PKU patients and their
Gita Bhatia, Stephen K. Tyring, Reuben Matalon, Kimberlee Michals-Matalon, Flemming Güttler   +4 more
openaire   +3 more sources

Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

Frontiers in Oncology, 2023
Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam, Steven C. Smith, Sundaresan Gobalakrishnan, Mina McGinn, Vasily A. Yakovlev, Christopher S. Rabender   +5 more
doaj   +1 more source

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

ACS Central Science, 2019
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes and tumor suppression.
Vanessa A N Kraft, C. T. Bezjian, S. Pfeiffer, L. Ringelstetter, Constanze Müller, Fereshteh Zandkarimi, J. Merl-Pham, Xuanwen Bao, N. Anastasov, Johanna Kössl, S. Brandner, Jacob D Daniels, P. Schmitt‐Kopplin, S. Hauck, B. Stockwell, K. Hadian, Joel A. Schick   +16 more
semanticscholar   +1 more source

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
Ernst R. Werner, Helmut Wachter, Gabriele Werner-Felmayer   +2 more
openaire   +3 more sources

Autoxidation and photooxidation of tetrahydrobiopterin: a theoretical study

Free radical research, 2020
Pterins are naturally occurring pigments and enzyme cofactors widespread in living organisms. Tetrahydrobiopterin (H4Bip) is a coenzyme of aromatic amino acid hydroxylases, NO-synthases, and alkylglycerol monooxygenases.
A. A. Buglak, T. A. Telegina, Y. Vechtomova, M. S. Kritsky   +3 more
semanticscholar   +1 more source

Pretreatment cognitive and neural differences between sapropterin dihydrochloride responders and non-responders with phenylketonuria [PDF]

, 2017
Sapropterin dihydrochloride (BH4) reduces phenylalanine (Phe) levels and improves white matter integrity in a subset of individuals with phenylketonuria (PKU) known as “responders.” Although prior research has identified biochemical and genotypic ...
Christ, Shawn E, Grange, Dorothy K, Hawks, Zoe, Rutlin, Jerrel, Shimony, Joshua, White, Desiree A   +5 more
core   +4 more sources

Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts [PDF]

, 2002
Objective: It has recently been proposed that nitric oxide synthase, in the presence of suboptimal levels of tetrahydrobiopterin, an essential cofactor of this enzyme, might favor increased production of oxygen radicals.
Koja, Kageharu, Matsuzaki, Toshihiro, Miyagi, Kanako, Nakasone, Junko, Noguchi, Katsuhiko, Sakanashi, Matao, Sakanashi, Mayuko, Yamashiro, Satoshi   +7 more
core   +1 more source