Results 21 to 30 of about 20,671 (210)

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Biomolecules, 2021
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO).
Anna Janaszak-Jasiecka, Anna Siekierzycka, Agata Płoska, Iwona T. Dobrucki, Leszek Kalinowski   +4 more
doaj   +1 more source

Hippo Pathway Drives Durable Non-Cell-Autonomous Ferroptosis Resistance in Lung Cancer. [PDF]

Cancer Sci
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Saleh MF, Nita A, Ohta Y, Kobayashi A, Li H, Sakamoto Y, Moroishi T.   +6 more
europepmc   +2 more sources

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

PLoS ONE, 2014
ObjectiveAim of this study was to identify the nitric oxide synthase (NOS) isoform involved in early microcirculatory derangements following solid organ transplantation.BackgroundTetrahydrobiopterin donor treatment has been shown to specifically ...
Benno Cardini, Katrin Watschinger, Martin Hermann, Peter Obrist, Rupert Oberhuber, Gerald Brandacher, Surawee Chuaiphichai, Keith M Channon, Johann Pratschke, Manuel Maglione, Ernst R Werner   +10 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
E R, Werner, G, Werner-Felmayer, H, Wachter   +2 more
openaire   +2 more sources

Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia [PDF]

, 2015
Maternal physiological hypercholesterolemia occurs during pregnancy, ensuring normal fetal development. In some cases, the maternal plasma cholesterol level increases to above this physiological range, leading to maternal supraphysiological ...
Fuenzalida, Bárbara, Gutiérrez, Jaime, Leiva, Andrea, Pardo, Fabián, Salomón, Carlos, Sanhueza, Carlos, Sobrevia, Luis, Toledo, Fernando, Westermeier, Francisco   +8 more
core   +9 more sources

Effect of Interferon-γ and LPS on Tetrahydrobiopterin in Rat PC 12 and Human KNA Cells

Pteridines, 2001
The first human phaeochromocytorna cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH).
Vrecko Karoline, Pfragner Roswitha, Siegl Veronika, Schauenstein Konrad, Reibnegger Gilbert   +4 more
doaj   +1 more source

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundRheumatoid arthritis is a systemic inflammatory condition associated with increased cardiovascular risk that may be due to underlying endothelial dysfunction and subsequent aortic stiffening.
Kaisa M. Mäki‐Petäjä, Lisa Day, Joseph Cheriyan, Frances C. Hall, Andrew J. K. Östör, Nicholas Shenker, Ian B. Wilkinson   +6 more
doaj   +1 more source