Results 41 to 50 of about 26,569 (299)

Perspectives on tetrahydrobiopterin research.

Folia Pharmacologica Japonica, 2001
Tetrahydrobiopterin ((6R)-L-erythro-tetrahydrobiopterin, BH4) is de novo synthesized from GTP. Enzymes involved in its synthesis are the rate limiting enzyme GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase. Abnormalities in the metabolism of BH4 have been demonstrated in some diseases affecting the central ...
Takahide Nomura, Hiroaki Shiraishi, Masatsugu Ohtsuki, Chiho Sumi-Ichinose   +3 more
openaire   +4 more sources

The regulation of vascular tetrahydrobiopterin bioavailability [PDF]

Vascular Pharmacology, 2013
6R l-erythro-5,6,7,8-tetrahydrobiopterin (BH4) is an essential cofactor for several enzymes including phenylalanine hydroxylase and the nitric oxide synthases (NOS). Oral supplementation of BH4 has been successfully employed to treat subsets of patients with hyperphenylalaninaemia.
Starr, Anna, Hussein, Dania, Nandi, Manasi   +2 more
openaire   +6 more sources

Tetrahydrobiopterin deficiency in schizophrenia as a new target for personalized medicine

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2020
Summary. Tetrahydrobiopterin (BH4) is an important cofactor, that involved in the synthesis of dopamine, norepinephrine, and serotonin, as well as affecting the production of nitric oxide (NO) and regulating the activity of the glutamatergic system.
I. V. Semennov, Y. S. Zagryazhskaya, A. S. Piatoikina, T. V. Zhilyaeva, E. A. Manakova A., A. S. Blagonravova, E. V. Verbitskaya, G. E. Mazo   +7 more
doaj   +1 more source

Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The present crystal structure of phenylalanine hydroxylase (PAH) provides the 3D structure of the full-length human PAH, both unbound and complexed with the tetrahydrobiopterin (BH4) cofactor. The BH4-bound state is physiologically relevant,
M. Flydal, Martín Alcorlo-Pagés, F. Johannessen, S. Martínez-Caballero, Lars Skjærven, R. Fernández-Leiro, Aurora Martínez, J. Hermoso   +7 more
semanticscholar   +1 more source

Effect of Interferon-γ and LPS on Tetrahydrobiopterin in Rat PC 12 and Human KNA Cells

Pteridines, 2001
The first human phaeochromocytorna cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH).
Vrecko Karoline, Pfragner Roswitha, Siegl Veronika, Schauenstein Konrad, Reibnegger Gilbert   +4 more
doaj   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype

Pteridines, 1993
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad, Thöny Beat, Heizmann Claus W., Dhondt Jean-Louis   +3 more
doaj   +1 more source

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Armbrust, Wineke, Bookelman, Sanne L., Cappon, Jeannette, Cowan, Katherine, De Boer, Joke, Dedding, Christine, Fernhout, Marlous J., Jongsma, Karin R., Kamphuis, Sylvia, Lelieveld, Otto T.H.M., Muller, Petra C.E.Hissink, Olsder, Wendy, Schatorjé, Ellen, Schoemaker, Casper G., Swart, Joost F., Van Den Berg, J. Merlijn, Van Der Net, Janjaap, Van Loosdregt, Jorg, Van Rensen, Annemiek, Van Vliet, Rens, Vastert, Sebastiaan J., Versluis, Els, Verwoerd, Anouk, Whiting, Caroline, Wulffraat, Nico M.   +24 more
core   +9 more sources

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability [PDF]

, 2005
Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated.
Clapp, BR, Deanfield, JE, Gallimore, JR, Hineorani, AD, Hirschfield, GM, MacAllister, RJ, Pepys, MB, Singer, M, Stidwill, RP, Storry, C, Vallance, P   +10 more
core   +1 more source

Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin-dependent alkylglycerol monooxygenase

Pteridines, 2013
The tetrahydrobiopterin-dependent degradation of ether lipids by alkylglycerol monooxygenase (AGMO) produces fatty aldehydes, which are toxic to cells.
Keller Markus A., Watschinger Katrin, Golderer Georg, Werner-Felmayer Gabriele, Werner Ernst R.   +4 more
doaj   +1 more source

PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway

British Journal of Pharmacology, 2019
Impaired endothelium‐dependent relaxation (EDR) is a hallmark of endothelial dysfunction. A deficiency of tetrahydrobiopterin (BH4) causes endothelial NOS to produce ROS rather than NO.
Zihui Zhang, Xinya Xie, Qinyu Yao, Jia Liu, Ying Tian, Chunmiao Yang, L. Xiao, Nanping Wang   +7 more
semanticscholar   +1 more source