Results 61 to 70 of about 20,671 (210)

Investigation of the Relationship Between Serum Tetrahydrobiopterin and Folic Acid Levels with Each Other and with Preeclampsia in the Second and Third Trimesters

Van Tıp Dergisi
INTRODUCTION: Aim: This study investigates the relationship between serum tetrahydrobiopterin (BH4) and folic acid levels in pregnant women during the second and third trimesters and the development of preeclampsia.
Mücahit Ahmet Aranlı, Kazım uckan, Aziz Gül, Yusuf Başkıran, İzzet Çeleğen   +4 more
doaj   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype

Pteridines, 1993
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad, Thöny Beat, Heizmann Claus W., Dhondt Jean-Louis   +3 more
doaj   +1 more source

Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder

Frontiers in Pediatrics, 2014
Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited.
Richard Eugene Frye, Daniel eRossignol
doaj   +1 more source

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source

Future Prospects of Imatinib in Advanced Pulmonary Hypertension Management

IUBMB Life, Volume 78, Issue 3, March 2026.
ABSTRACT Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by elevated pulmonary arterial pressure and increased vascular resistance. This hemodynamic strain forces the right ventricle to pump against a high‐pressure system, ultimately leading to right‐sided heart failure and death.
Federica Davì, Stella Mangione, Antonella Iaconis, Tiziana Genovese, Nicla Tranchida, Salvatore Cuzzocrea   +5 more
wiley   +1 more source

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]

, 2017
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau, Nenad, Dhondt, Jean-Louis, Heizmann, Claus W., Thöny, Beat   +3 more
core  

Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? [PDF]

, 2017
Although convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress, and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not ...
Liang, Mingyu, Montezano, Augusto C., Rios, Francisco, Touyz, Rhian M., Widlansky, Michael E.   +4 more
core   +1 more source

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 2002
Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro, Shimizu Shumchi, Ishii Masakazu, Yamamoto Shinichiro, Iwasaki Michiko, Yamamoto Toshinori, Kiuchi Yuji   +6 more
doaj   +1 more source

Cellular signaling and NO production [PDF]

, 2010
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial ...
Michel, T, Vanhoutte, PM
core   +1 more source

Tyrosine Hydroxylase Deficiency Impairs TH Axonal Transport, Brain Function, and Neuronal Plasticity

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder caused by biallelic pathogenic variants in the Th gene, leading to a deficiency in the rate‐limiting enzyme for the synthesis of dopamine (DA) and other catecholamine neurotransmitters.
Tie‐Jun Sten Shi, Kunwar Jung‐KC, Gong‐Wei Lyu, Liang Han, Ming Ying, Beat Thöny, Aurora Martinez   +6 more
wiley   +1 more source