Results 61 to 70 of about 23,156 (257)
Mediators of leukocyte yctivation play a role in disseminated intravascular coagulation during orthotopic liver transplantation [PDF]
, 1994 Leukocytes play an important role in the development of disseminated intravascular coagulation (DIC). In the reperfusion phase of OLT a DIC-like situation has been described and has been held responsible for the high blood loss during this phase.
Bechstein, W. O. +6 more
core
Cellular signaling and NO production [PDF]
, 2010 The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial ...
Michel, T, Vanhoutte, PM
core +1 more source
Analgesia by inhibiting tetrahydrobiopterin synthesis [PDF]
Current Opinion in Pharmacology, 2012 Physiological control of the co-factor tetrahydrobiopterin (BH4) is tight in normal circumstances but levels increase pathologically in the injured somatosensory system. BH4 is an essential co-factor in the production of serotonin, dopamine, epinephrine, norepinephrine and nitric oxide.
Michael, Costigan +2 more
openaire +2 more sources
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging
Aging Cell, Volume 25, Issue 2, February 2026.Aging impairs cerebrovascular health by driving mitochondrial dysfunction, oxidative stress, endothelial failure, and neurovascular uncoupling, leading to BBB breakdown and cognitive decline. In contrast, time‐restricted feeding/eating counteracts these mechanisms by restoring mitochondrial function, activating adaptive nutrient‐sensing pathways ...
Madison Milan +13 more
wiley +1 more source
Advanced Therapeutics, Volume 9, Issue 1, January 2026.Researchers establish a high‐throughput screening technique that identifies adenosine 5′‐monophosphate as a novel activator of 5‐oxoprolinase (OPLAH). To enhance cellular permeability, they employ spermine‐modified acetalated dextran nanoparticles for effective intracellular delivery.
Antonio Esquivel‐Gaytan +12 more
wiley +1 more source
Tetrahydrobiopterin Deficiency: From Phenotype to Genotype
Pteridines, 1993 As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad +3 more
doaj +1 more source
Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder
Frontiers in Pediatrics, 2014 Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited.
Richard Eugene Frye, Daniel eRossignol
doaj +1 more source
New approaches of morfofunktional pharmacological correction of violations of cardiovascular system in experimental preeclampsia [PDF]
, 2016 Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 to 20 days of pregnancy.
Gureev, V. V.
core +2 more sources
Brain and Behavior, Volume 16, Issue 1, January 2026.Metabolomics‐based analysis of SAE mice by brain‐gut axis found that metabolic pathway analysis indicates that these differential metabolites are mainly involved in the metabolism of linoleic acid, biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism in the brain.
Yu Ke +8 more
wiley +1 more source
Pteridines, 2002 Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro +6 more
doaj +1 more source