Results 71 to 80 of about 23,011 (262)

Treatment With Tetrahydrobiopterin Improves White Matter Maturation in a Mouse Model for Prenatal Hypoxia in Congenital Heart Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities in utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase.
Jennifer Romanowicz, Camille Leonetti, Zaenab Dhari, Ludmila Korotcova, Shruti D. Ramachandra, Nemanja Saric, Paul D. Morton, Shivani Bansal, Amrita Cheema, Vittorio Gallo, Richard A. Jonas, Nobuyuki Ishibashi   +11 more
doaj   +1 more source

Cellular signaling and NO production [PDF]

, 2010
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth muscle, by releasing vasodilator substances. The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial ...
Michel, T, Vanhoutte, PM
core   +1 more source

Endothelial Cell Tetrahydrobiopterin [PDF]

Circulation Research, 2007
See related article, pages 830–838 The predilection of atherosclerosis for specific locations in the vasculature strongly suggests that the response of the arterial wall to alterations in blood flow is an important factor in vascular disease pathogenesis.
De Bono, J, Channon, K
openaire   +1 more source

Mutation spectrum of PTS gene in patients with tetrahydrobiopterin deficiency from jiangxi province [PDF]

, 2022
Kang Xie, Baitao Zeng, Liuyang Zhang, Shaohong Chen, Yongyi Zou, Huizhen Yuan, Shuhui Huang, Feng Wang, Qing Lü, Yanqiu Liu, Bicheng Yang   +10 more
openalex   +1 more source

Relationship Between Gut Microbiota and Phenylalanine Levels: A Mendelian Randomization Study

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study showed that Family XIII AD3011 group was associated with reduced Phe levels, providing important evidence to reveal the interaction between gut microbiota and Phe levels, and providing a scientific basis for the development of personalized diet and nutrition recommendations for PKU patients.
Zhijuan Liu, Minggang Ye, Huiya Jin, Weixia Chen, Hasitiyaer Jieens, Rui Han   +5 more
wiley   +1 more source

Linoleic acid-induced endothelial activation

Journal of Lipid Research, 2004
Hypertriglyceridemia, an important risk factor of atherosclerosis, is associated with increased circulating free fatty acids. Research to date indicates that linoleic acid (LA), the major fatty acid in the American diet, may be atherogenic by activating ...
Viswanathan Saraswathi, Guoyao Wu, Michal Toborek, Bernhard Hennig   +3 more
doaj   +1 more source

Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap? [PDF]

, 2017
Although convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress, and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not ...
Liang, Mingyu, Montezano, Augusto C., Rios, Francisco, Touyz, Rhian M., Widlansky, Michael E.   +4 more
core   +1 more source

Autophagy induction by tetrahydrobiopterin deficiency [PDF]

Autophagy, 2011
Tetrahydrobiopterin (BH₄) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article, the signaling pathway by which BH₄ deficiency inactivates mTORC1 leading to the activation of the autophagic pathway was studied utilizing BH₄-deficient Spr(-/-) mice generated by the knockout of ...
Kwak, SS Kwak, Sang-Su, Suk, JK Suk, Jin-Kyu, Choi, JH Choi, Ji-Hye, Yang, SK Yang, Seung-Kyung, Kim, JW Kim, Jin-Woo, Sohn, SH Sohn, Seong-Hyang, Chung, JH Chung, Jae-Hoon, Hong, YH Hong, Yong-Hee, Lee, DH Lee, Dong-Hwan, Ahn, JK Ahn, Jeong-Keun, Min, HS Min, Hye-Sun, Fu, YM Fu, Ya-Min, Meadows, GG Meadows, Gary G., Joe, CO Joe, Cheol-O   +13 more
openaire   +2 more sources

Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5

FASEB BioAdvances, Volume 7, Issue 12, December 2025.
Exogenous formate administration reduces myocardial ischemic injury in intact alcohol dehydrogenase 5 knockout (ADH5−/−) female mice, but not in intact or ovariectomized wild‐type female mice. One‐carbon metabolism may play an intermediate role. This graphic was generated using BioRender.
Haley Garbus‐Grant, Obialunanma V. Ebenebe‐Kasonde, Raihan Kabir, Mark J. Kohr   +3 more
wiley   +1 more source

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases

Pteridines, 2006
Endothelial vasodilator dysfunction is a characteristic feature of patients at risk for coronary atheroscierosis. We have reported that insulin resistance may be a pathogenic factor for endothehal dysfunction through impaired endothelial nitric oxide ...
Shinozaki Kazuya, Kashiwagi Atsunori, Masada Masahiro, Okamura Tomio   +3 more
doaj   +1 more source