Results 71 to 80 of about 26,569 (299)
British Journal of Pharmacology, 2017 The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS‐derived NO and ROS signalling in vascular physiology.
S. Chuaiphichai +6 more
semanticscholar +1 more source
Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury
Advanced Materials Interfaces, Volume 12, Issue 11, June 9, 2025.This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui +5 more
wiley +1 more source
Pteridines, 2017 Dictyostelium discoideum Ax2 is well-known for the synthesis of d-threo-tetrahydrobiopterin (DH4) with a smaller amount of l-erythro-tetrahydrobiopterin (BH4).
Kim Hye-Lim +2 more
doaj +1 more source
Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice
Scientific Reports, 2017 Tetrahydrobiopterin (BH4) is a cofactor of a number of regulatory enzymes. Although there are no known BH4 exogenous sources, the tissue content of this biopterin increases with age in GTP cyclohydrolase 1-deficient hyperphenylalaninemia-1 (hph-1) mice ...
J. Belik +6 more
semanticscholar +1 more source
Epilepsia Open, Volume 10, Issue 3, Page 965-970, June 2025.Abstract Dravet syndrome (DS) is an early onset, developmental, and epileptic encephalopathy characterized by drug‐resistant seizures and multiple comorbidities. It has been reported that in adulthood, it may be accompanied by parkinsonism, but the pathogenesis of this condition remains unclear.
Ryo Sugiyama +5 more
wiley +1 more source
Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli
Pteridines, 2013 Alkylglycerol monooxygenase (AGMO; EC 1.14.16.5) is the only enzyme known to cleave the O-alkyl ether bond of alkylglycerols in humans. It is an integral membrane protein with nine predicted transmembrane domains.
Mayer Matthias +5 more
doaj +1 more source
Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects
MedComm, Volume 6, Issue 6, June 2025.As a polyphenol substance with important potential, resveratrol has important potential in degenerative diseases, cardiovascular diseases, cancer, neurological diseases, etc. However, it is still necessary to pay attention to its bioavailability and potential adverse effects.
Zhuo‐qun Ren +8 more
wiley +1 more source
Analgesia by inhibiting tetrahydrobiopterin synthesis [PDF]
Current Opinion in Pharmacology, 2012 Physiological control of the co-factor tetrahydrobiopterin (BH4) is tight in normal circumstances but levels increase pathologically in the injured somatosensory system. BH4 is an essential co-factor in the production of serotonin, dopamine, epinephrine, norepinephrine and nitric oxide.
Alban Latremoliere +2 more
openaire +3 more sources
Genes, Brain and Behavior, Volume 24, Issue 3, June 2025.ABSTRACT Neurodegeneration in Huntington disease (HD) contributes to dopaminergic system dysfunction via the loss of striatal medium spiny neurons expressing dopamine receptors. Given the key role for ascorbic acid (vitamin C) in dopamine synthesis and neurotransmission, we investigated whether mild cellular ascorbate deficiency accelerates ...
Adriana A. Tienda +2 more
wiley +1 more source
Challenges in the management of Phenylketonuria in Malta [PDF]
, 2016 Phenylketonuria (PKU) is a rare metabolic disorder comprising a number of different enzyme deficiencies. In Malta, dihydropteridine reductase (DHPR) deficiency appears to be more common than phenylalanine hydroxylase deficiency (classical PKU), and is ...
Attard Montalto, Simon, Attard, Stephen
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