Results 71 to 80 of about 23,156 (257)

Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]

, 2017
As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau, Nenad, Dhondt, Jean-Louis, Heizmann, Claus W., Thöny, Beat   +3 more
core  

Chemical structure of 1-O-(L-erythro-biopterin-2'-yl)-a-glucose isolated from a cyanobacterium Synechococcus sp. PCC 7942

Pteridines, 2001
A pteridine glycoside in Synechococcus sp. PCC 7942, the structure of which had been tentatively identified as biopterin-glucoside, was isolated and characterized for its exact chemical structure by 2D-NMR spectroscopy. The determined structure is 1-0-(L-
Choi Yong Kee, Hwang Yoon Kyung, Kang Yong Han, Park Young Shik   +3 more
doaj   +1 more source

Successful Management of Two Consecutive Pregnancies With Maternal–Fetal Phenylketonuria: Lessons From Clinical Practice

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Phenylketonuria (PKU) is an autosomal recessive disorder caused by a deficiency of phenylalanine hydroxylase (PAH), leading to the accumulation of phenylalanine (Phe) and an increased risk of developmental disorders. Treatment involves a Phe‐restricted diet, amino acid supplements, and for a subset of patients, a tetrahydrobiopterin (BH4 ...
Per Lundkvist, Karin Blom Malmberg, Linda Lindström, Andreas Kindmark   +3 more
wiley   +1 more source

Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells

Pteridines, 1997
We examined the inhibitory effect of tetrahydrobiopterin (BPH4) on L-β-(3,4-dihydroxyphenyl)alanine (DOPA)-induced cytotoxicity in PC-12 cells. First in vitro inhibitory efficacy of BPH4 on lipid peroxidation induced by Fe3+-DOPA complex was confirmed by
Kojima Shuji, Kugenuma Hiroshi, Oyobe Sayaka, lizuka Hiroyuki, Ikekita Masahiko   +4 more
doaj   +1 more source

Oxygenase Domain of Drosophila melanogaster Nitric Oxide Synthase: Unique Kinetic Parameters Enable a More Efficient NO Release [PDF]

, 2007
Although nitric oxide (NO) is important for cell signaling and nonspecific immunity in the fruit fly Drosophila melanogaster, little is known about its single NO synthase (dNOS).
Bhattacharjee, A., Dutta, T., Ghosh, S., Ray, S. S., Regulski, M. R., Stuehr, D. J., Tejero, J., Tully, T., Wang, Z. Q.   +8 more
core   +1 more source

Endothelial Cell Tetrahydrobiopterin [PDF]

Circulation Research, 2007
See related article, pages 830–838 The predilection of atherosclerosis for specific locations in the vasculature strongly suggests that the response of the arterial wall to alterations in blood flow is an important factor in vascular disease pathogenesis.
De Bono, J, Channon, K
openaire   +1 more source

Association Between the Dutch Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND‐NL) Diet Adherence and Systemic Tryptophan Metabolites in Older Adults at Risk of Cognitive Decline: An Exploratory Study

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Following the MIND diet may support brain health in older adults at risk of cognitive decline by influencing tryptophan (TRP) metabolism. Plasma samples and dietary intake data from the HELI intervention trial were used. Bivariate latent change score modeling analysis showed that greater adherence to the MIND diet was linked to higher tryptophan levels,
Sonja Beers, Lisette C. P. G. M. de Groot, Mark R. van Loenen, Lianne B. Remie, Mechteld Grootte Bromhaar, Andrea Anesi, Urska Vrhovsek, Joukje M. Oosterman, Esther Aarts, Mara P. H. van Trijp, Yannick Vermeiren   +10 more
wiley   +1 more source

Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B. [PDF]

, 2015
UnlabelledNitric oxide (NO) plays an important signaling role in all domains of life. Many bacteria contain a heme-nitric oxide/oxygen binding (H-NOX) protein that selectively binds NO.
Marletta, Michael A, Rao, Minxi, Smith, Brian C   +2 more
core   +3 more sources

Effect of phototherapy on event-related potentials in patients with post-stroke depression through serum tetrahydrobiopterin level intervention: a clinical study. [PDF]

BMC Psychiatry
Xie B, Wu Z, Zhou Z, Lu W, Liu L, Zhang L.   +5 more
europepmc   +3 more sources

Autophagy induction by tetrahydrobiopterin deficiency [PDF]

Autophagy, 2011
Tetrahydrobiopterin (BH₄) deficiency is a genetic disorder associated with a variety of metabolic syndromes such as phenylketonuria (PKU). In this article, the signaling pathway by which BH₄ deficiency inactivates mTORC1 leading to the activation of the autophagic pathway was studied utilizing BH₄-deficient Spr(-/-) mice generated by the knockout of ...
Kwak, SS Kwak, Sang-Su, Suk, JK Suk, Jin-Kyu, Choi, JH Choi, Ji-Hye, Yang, SK Yang, Seung-Kyung, Kim, JW Kim, Jin-Woo, Sohn, SH Sohn, Seong-Hyang, Chung, JH Chung, Jae-Hoon, Hong, YH Hong, Yong-Hee, Lee, DH Lee, Dong-Hwan, Ahn, JK Ahn, Jeong-Keun, Min, HS Min, Hye-Sun, Fu, YM Fu, Ya-Min, Meadows, GG Meadows, Gary G., Joe, CO Joe, Cheol-O   +13 more
openaire   +2 more sources