Results 71 to 80 of about 36,463 (268)

Tetrahydrocannabinol and dopamine D1 receptor

Frontiers in Neuroscience, 2023
Dopamine, a neurotransmitter and neuromodulator, is primarily released by dopaminergic neurons in the midbrain, particularly in the substantia nigra and the ventral tegmental area (VTA). Dopamine is known to have 5 receptors which are D1, D2, D3, D4 and D5, which are further categorized into 2 families: D1 family and D2 family.
openaire   +3 more sources

Analytical Approaches to Address Challenges in the Analysis of Cannabinoids in Vascular Matrices Using Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Phytocannabinoids are bioactive metabolites derived from the Cannabis sativa plant. They have garnered attention due to their recreational uses and therapeutic potential. Although various analytical strategies have been employed for their analysis, mass spectrometry (MS) coupled to chromatographic separation is superior due to its sensitivity ...
Radwa Mahmoud, Robert B. Laprairie, Anas El‐Aneed   +2 more
wiley   +1 more source

The impact of recreational cannabinoid legalization on utilization in a pregnant population

Frontiers in Public Health
BackgroundMarijuana potency and utilization both continue to increase across the United States. While the overall prevalence of cannabinoid utilization during pregnancy has been surveyed in various studies, the direct impact of changing governmental ...
Jacob Torres, Colton Miller, Michael Apostol, Jessica Gross, Jessie R. Maxwell, Jessie R. Maxwell   +5 more
doaj   +1 more source

Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva

Chemistry Central Journal, 2016
BackgroundCannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of cannabis, is highly desirable for roadside testing.ResultsA screen printed ...
C. Wanklyn, Daniel Burton, Emma Enston, Carrie-Ann Bartlett, Sarah Taylor, Aleksandra Raniczkowska, Murdo M. Black, L. Murphy   +7 more
semanticscholar   +1 more source

Documented End‐of‐Life Preferences of People With Parkinson's Disease or Parkinsonism Across Europe

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease and atypical parkinsonism are characterized by motor and non‐motor symptoms. As the disease advances, planning for end‐of‐life (EoL) care becomes increasingly important. However, consensus‐based European guidelines for advance care planning and documentation of EoL care preferences for parkinsonism are lacking ...
Bauke W. Dijkstra, Catharina Muente, Michela Garon, Kristina Rosqvist, Monica Scharfenort, Katharina M. Lex, Philip Poku, Eirini Nixina, Pille Taba, Ülle Krikmann, Katrin Sikk, Katie Flanagan, Anette E. Schrag, Spyros Konitsiotis, Miltiadis Makrydimas, Stefan Lorenzl, Per Odin, David J. Pedrosa, Kris C.P. Vissers, Marieke M. Groot, Bastiaan R. Bloem, Marjan J. Meinders, Angelo Antonini, the PD_Pal consortium, Argyri Tsakanika, Dhaval Trivedi, Dimitri Gatsios, Dimitrios Fotiadis, K. Ray Chaudhuri, Nikolaos Moschos, Piret Paal   +30 more
wiley   +1 more source

Development and validation of reverse phase high performance liquid chromatography method for the determination of delta-9-tetrahydrocannabinol and cannabidiol in oromucosal spray from cannabis extract

Revista Brasileira de Farmacognosia, 2018
A simple, fast, precise, accurate and responsive high performance liquid chromatography method was developed and validated carefully for determining an amount of delta-9-tetrahydrocannabinol and cannabidiol.
Worawan Saingam, A. Sakunpak
semanticscholar   +1 more source

Gray Matter Volume Loss in Parkinson's Disease Psychosis and Cannabinoid Receptor Gene Expression in the Brain

Movement Disorders, EarlyView.
Abstract Background Serotonergic and dopaminergic pathways are implicated in Parkinson's disease psychosis (PDP), but preliminary evidence also implicates the endocannabinoid system (ECS). Objectives We examined the association of gray matter volume loss in PDP patients with brain expression of the genes coding for CB1 (cannabinoid type 1) and CB2 ...
Sara Pisani, František Váša, Latha Velayudhan, Sagnik Bhattacharyya   +3 more
wiley   +1 more source

Effects of Transition Metals (TM = Nb, Ta, and Zr) on Thermodynamic and Electronic Properties of Advanced (Th1−xTMx)C (x = 0.1 and 0.2) Fuels: A First‐Principles Study

Materials Genome Engineering Advances, EarlyView.
First‐principles study reveals Zr‐doped ThC maintains superior thermal conductivity and rigidity; Ta‐doping induces structural softening, whereas Nb enhances covalent bonding. These atomic‐scale insights guide the design of advanced thorium‐based nuclear fuels with tailored thermomechanical properties.
Baihui Su, Jia Li, William Yi Wang, Yonghong Lu, Xiaoqiang Pan, Xingyu Gao, Haifeng Song, Jinshan Li   +7 more
wiley   +1 more source

Application of the QuEChERS procedure for analysis of Δ9-tetrahydrocannabinol and its metabolites in authentic whole blood samples by GC–MS/MS

Forensic Toxicology, 2018
PurposeAnalysis of drugs and their metabolites in biofluids usually demands the application of sample preparation methods that allow for full isolation of analyzed substances from the matrix.
Michał P. Dybowski, A. Dawidowicz
semanticscholar   +1 more source

Nitroxide‐Mediated Polymerization Synthesis of Geminal Bisphosphonate‐Functionalized (Co)polymers and Their Affinity to Hydroxyapatite Surface

Journal of Polymer Science, EarlyView.
A novel styrenic monomer bearing gem‐bisphosphonate groups is synthesized in a single step. The nitroxide‐mediated (co)polymerization of this monomer proceeds in a well‐controlled manner, yielding bisphosphonate‐functionalized (co)polymers with low dispersity.
Hien The Ho, Nam Hoai Nguyen, Marion Rollet, Didier Gigmes, Trang N. T. Phan   +4 more
wiley   +1 more source