Results 101 to 110 of about 3,627 (215)

Selective suppression of the JNK-MMP2/9 signal pathway by tetramethylpyrazine attenuates neuropathic pain in rats

, 2017
Background Activated astrocytes release matrix metalloproteinase-2/9 (MMP-2/9) to induce central sensitization and maintain neuropathic pain. However, the mechanisms involved in the activation of MMP-2/9 on astrocytes during pain remain poorly understood.
Cai-Long Pan, Wen-Tao Liu, Lei Liu, Jun-Wei Qu, Chao-Yu Wang, Bing-Qian Liu, Yang Yang, Yuan Han, Liang Hu, Lai Jiang   +9 more
core   +1 more source

Investigation of tetramethylpyrazine degradation in Rhodococcus sp. TMP1 bacteria.

, 2013
The catabolism of alkylpyrazines is poorly described. The pathways for the degradation of di- and tri-substituted pyrazines have been proposed, but these related routes consistently include a hydroxylation step that cannot be performed on ...
Kutanovas, Simonas,
core  

Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis

, 2018
Tetramethylpyrazine (TMP) is a traditional Chinese herbal medicine with strong anti-inflammatory and cartilage protection activities, and thus a promising candidate for treating osteoarthritis.
Xiuping Zhang, Yang Shi, Guihua Huang, Zhenlei Yang, Zhiyue Zhang   +4 more
core   +1 more source

The mechanism of Laceyella sacchari FBKL4.010 produced tetramethylpyrazine in the liquid fermentation by comparative transcriptomic techniques

Frontiers in Microbiology
Tetramethylpyrazine (TTMP) is considered a crucial flavor component in Moutai-flavored liquor. Laceyeella sacchari FBKL4.010 (L. sacchari) is the dominant species found in Moutai-flavor Daqu, and this study aims to determine the mechanism by which L ...
Xiaodan Wang, Xiaodan Wang, Wu Huang, Wu Huang, Jin Huang, Xiaoye Luo, Xiaoye Luo, Mingbo Nie, Tao Jiang, Shidong Ban, Pei Li, Pei Li   +11 more
doaj   +1 more source

Formation and identification of trimethylimidazole during tetramethylpyrazine production from glucose by Bacillus strains

, 2009
During 2,3,5,6-tetramethylpyrazine production from glucose by Bacillus strains, a novel product was detected and identified as 2,4,5-trimethylimidazole (TMI) by GC/MS.
Xiao, Zijun, Lu, Jian R.; id_orcid, Ma, Cuiqing, Xu, Ping   +3 more
core   +1 more source

Screening and identification of a bacterial strain for the production of tetramethylpyrazine through solid-state fermentation and determination of its high-yield mechanism

Journal of Taibah University for Science
In this study, a strain producing a high yield (1.72 mg·g–1) of tetramethylpyrazine (TTMP) was screened under solid-state conditions from high-temperature Daqu and was identified as Bacillus velezensis using 16S rDNA molecular technology.
Wanwan Zhuansun, Jun Xu, Zhiqiang Li, Hengzhao Liu, Yin Zhao, Lulu Chen, Shufang Shan, Xin Zeng, Binyue Xin, Huawei Zeng, Qinxiang Xu   +10 more
doaj   +1 more source

Sustainable production of 2,3,5,6-Tetramethylpyrazine at high titer in engineered Corynebacterium glutamicum [PDF]

The industrial amino acid production workhorse, Corynebacterium glutamicum naturally produces low levels of 2,3,5,6-tetramethylpyrazine (TMP), a valuable flavor, fragrance, and commodity chemical.
Banerjee, Deepanwita, Simmons, Blake A, Pidatala, Venkataramana R, Eudes, Aymerick, Srinivasan, Aparajitha, Oka, Asun, Chen-Xiao, Kevin, Eng, Thomas, Mukhopadhyay, Aindrila   +8 more
core   +1 more source

Copper(II) complexes of hindered diazines: tetramethylpyrazine

Two copper(II) complexes of 2,3,5,6-tetramethylpyrazine (tmpz) are reported, [Cu(tmpz)Cl2]n (1), and [Cu(tmpz)Br2]n (2). The compounds crystallize in the monoclinic space group C2/m as pyrazine-bridged linear chains (parallel to the b-axis). The pyrazine
Butcher, Robert T., Landee, Christopher, Dickie, Diane A., Turnbull, Mark M   +3 more
core   +1 more source

3-(4-Hydroxy-3-methoxyphenyl)acrylic acid–2,3,5,6-tetramethylpyrazine (2/1)

, 2011
The asymmetric unit of the title compound, C8H12N2·2C10H10O4, contains a tetramethylpyrazine molecule, situated about an inversion center, and two substituted acrylic acid derivatives.
Lin Luo, Zaiyou Tan, Zhuohui Lin, Ruisi Yan, Erjia Zhu   +4 more
core   +1 more source

Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system

, 2019
In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS).
Xiaoge Hu, Xianghua Piao, Qibo Zhang, Jihui Zhao, Yulu Yan, Kuan Zhou, Ning Cheng, Yongtai Zhang, Nianping Feng   +8 more
core   +1 more source