Results 101 to 110 of about 3,816 (178)

Tetramethylpyrazine protects mice against thioacetamide-induced acuted hepatotoxicity

, 2016
[[abstract]]In this study, the intraperitoneal administration of 1 mg/kg thioacetamide (TAA) produced hepatotoxicity in mice. The increase in serum SGOT and SGPT produced at 24 h by this regimen was decreased in a dose-dependent manner by ...
劉吉豐, So, EC;Wong, KL;Huang, TC;Tasi, SC;Liu, CF   +1 more
core  

A Critical Review of Tetramethylpyrazine: Diseases and Derivatives

As the primary active constituent of the traditional Chinese medicinal herb Ligusticum chuanxiong, Tetramethylpyrazine (TMP) has demonstrated broad therapeutic potential across multiple disease areas.
Sixun Zeng, Jie Fan, Fenghua Zhang, Yingxian Liu, Wangping Ma, Hang Xu   +5 more
core   +1 more source

Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species

, 2010
Aim of the study: To determine the inhibitory effect of tetramethylpyrazine (TMP) on lipopolysaccharide (LPS)-induced over-production of nitric oxide (NO) and inducible nitric oxide synthase (iNOS) in N9 microglial ...
Wang, Ying-Xiong, Li, Wen-Ming, Liu, Hong-Tao, He, Jun-Lin, Chen, Wen-Juan, Yu, Chao, Yang, Zhu, Du, Yu-Guang   +7 more
core   +1 more source

Beneficial effects of combined terlipressin and tetramethylpyrazine administration on portal hypertensive rats

, 1999
The purpose of this study was to investigate the therapeutic effects of terlipressin (TP) alone or in combination with tetramethylpyrazine (TMP) on anesthetized portal hypertensive rats.
Chuang-Ye Hong, Ke-Ji Chen, Fang-Chi Chang, Yi-Tsau Huang, Jaung-Geng Lin, Han-Chieh Lin   +5 more
core   +1 more source

Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway

Frontiers in Pharmacology
BackgroundTetramethylpyrazine (TMP) is a natural alkaloid compound with antioxidant and neuroprotective effects. We hypothesized that TMP could exert neuroprotective effects by inhibiting ferroptosis through modulating iron metabolism, but its mechanism ...
Jingwei Tao, Jingwei Tao, Jingya Zhou, Hanjie Zhu, Lin Xu, Jizhou Yang, Xiaohong Mu, Xiao Fan   +7 more
doaj   +1 more source

Protection by Tetramethylpyrazine in acute absolute ethanol-induced gastric lesion

, 2016
[[abstract]]Acute oral administration of absolute ethanol (1.0 ml/kg) to fasting rats produced extensive necrosis of the gastric mucosa within 1 h. Pretreatment 30 min before administration of ethanol with oral tetramethylpyrazine (TMP) prevented this ...
劉吉豐, Liu, Chi-Feng;Lin, Chun-Ching;Ng, Lean-Teik;Lin, Song-Chow   +1 more
core  

Effect of tetramethylpyrazine on lipid peroxidation in strptozotocin-induced diabetic mice

, 2016
[[abstract]]Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. In the present study, we investigated the effect of tetramethylpyrazine (TMP) (10, 25 and 50 mg/kg), an active component of a Chinese ...
劉吉豐, Lee, Liang-Ming;Liu, Chi-Feng;Yang, Pao-Pao   +1 more
core  

Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappa B signaling pathways

, 2009
Aim of the study: To determine the anti-inflammatory effects of Tetramethylpyrazine (TMP) and to investigate the inhibitory effect of TMP on IL-8 production in human umbilical vein endothelial cells (HUVECs) induced by LIPS might be mediated by ...
Li, Wen-Ming, Liu, Hong-Tao, He, Jun-Lin, Yu, Chao, Li, Xiu-Ying   +4 more
core   +1 more source

Antioxidative effects of tetramethylpyrazine on ethanol-induced lipid peroxidaion

, 2016
[[abstract]]Acute p.o. administration of 99.5% ethanol (0.1 ml) to fasted mice produced heart toxicity. Pretreatment with p.o. administration of tetramethylpyrazine (TMP) could prevent such toxicity effectively and dose-dependently.
劉吉豐, Liu, Chi-Feng;Lin, Chia-Hsien;Chen, Chin-Fa;Huang, Tian-Chyuan;Lin, Song-Chow   +1 more
core  

The (2:1) complex of picric acid with tetramethylpyrazine. The structure,l IR spectra and tunnel splitting of methyl groups

, 2010
The crystal structure of 2:1 picric acid (PAH) with tetramethylpyrazine (TMP) was determined by using X-ray diffraction studies. Two equivalent N+-H center dot center dot center dot O- hydrogen bonds are formed with the length of 2.601 angstrom ...
Pawlukojc, A., Wuttke, J., Sawka-Dobrowolska, W., Sobczyk, L., Bator, G., Grech, E., Nowicka-Scheibe, J.   +6 more
core   +1 more source