Results 131 to 140 of about 3,718 (180)

Optimizing Nav1.7-Targeted Analgesics: Revealing Off-Target Effects of Spider Venom-Derived Peptide Toxins and Engineering Strategies for Improvement. [PDF]

Adv Sci (Weinh)
Luo S, Zhou X, Wu M, Wang G, Wang L, Feng X, Wu H, Luo R, Lu M, Ju J, Wang W, Yuan L, Luo X, Peng D, Yang L, Zhang Q, Chen M, Liang S, Dong X, Hao G, Zhang Y, Liu Z.   +21 more
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Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin

Organic Letters, 2021
Despite decades of research, the biosynthesis of tetrodotoxin, also known as a puffer fish toxin, remains an unsolved mystery. We disclose a synthesis of the 8-deoxy analogue of 4,9-anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a possible biosynthetic precursor of tetrodotoxin isolated from the Japanese toxic newt, by an intramolecular radical cyclization
Tadachika Miyasaka, Masaatsu Adachi, Toshio Nishikawa   +2 more
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C5–C10 Directly Bonded Tetrodotoxin Analogues: Possible Biosynthetic Precursors of Tetrodotoxin From Newts

Angewandte Chemie International Edition, 2014
AbstractThe identification of novel tetrodotoxin (TTX,1) analogues would significantly contribute to the elucidation of its biosynthetic pathway. In this study, the first C5–C10 directly bonded TTX analogues, 4,9‐anhydro‐10‐hemiketal‐5‐deoxyTTX (2) and 4,9‐anhydro‐8‐epi‐10‐hemiketal‐5,6,11‐trideoxyTTX (3), were found in the newtCynops ensicauda popeiby
Yuta, Kudo, Yoko, Yamashita, Dietrich, Mebs, Yuko, Cho, Keiichi, Konoki, Takeshi, Yasumoto, Mari, Yotsu-Yamashita   +6 more
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Tetrodotoxin and Its Analogues in Food: Recent Updates on Sample Preparation and Analytical Methods Since 2012

Journal of Agricultural and Food Chemistry, 2022
Tetrodotoxin (TTX), found in various organisms including pufferfish, is an extremely potent marine toxin responsible for numerous food poisoning accidents. Due to its serious toxicity and public health threat, detecting TTX and its analogues in diverse food matrices with a simple, fast, efficient method has become a worldwide concern.
Cong Hu, Yuan Zhang, Yu Zhou, Yang-jia-yi Xiang, Zhi-fei Liu, Zhi-hong Wang, Xue-song Feng   +6 more
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Tetrodotoxin and its analogues profile in nemertean species from the sea of Japan

Toxicon, 2018
For the first time search for tetrodotoxin (TTX) and its analogues in the extracts of nemerteans using HPLC-MS/MS was performed. TTX analogues were detected in two nemertean species in addition to TTX: 7 analogues were detected in the extract of Cephalothrix simula, 3 analogues - in the extract 11-norTTX of Kulikovia manchenkoi. Presence of 5-deoxyTTX,
A.E. Vlasenko, P.V. Velansky, A.V. Chernyshev, V.G. Kuznetsov, T. Yu. Magarlamov   +4 more
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Tetrodotoxin and analogues in two local pufferfish species from Inhaca Island – South of Mozambique: First report in the Mozambican coast

Toxicon, 2022
Tetrodotoxins (TTXs) were investigated in two local pufferfish species, Diodon hystrix and Arothron hispidus, from Mozambican coast. TTX and analogues 4-epiTTX, 4,9-anhydroTTX, 11-deoxyTTX, and 11-norTTX-6-(R/S)-ol were found in both species and high level of TTX was found in A. hispidus (9522.0 μg TTX kg-1) than in D. hystrix (350.9 μg TTX kg-1).
Isidro José Tamele, Ilário Timba, Pedro Reis Costa, Vitor Vasconcelos   +3 more
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Tetrodotoxin and its analogues in extracts from the toad Atelopus oxyrhynchus (family: Bufonidae)

Toxicon, 1992
Tetrodotoxin and its analogues, 4-epitetrodotoxin and 4,9-anhydrotetrodotoxin, were detected in the toad Atelopus oxyrhynchus by HPLC analysis. The toxin and its analogues were still present in a specimen which lived 3.5 years in captivity.
M, Yotsu-Yamashita, D, Mebs, T, Yasumoto
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The quite low cross-reactivity of Kawatsu's anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish

Toxicon, 2023
The monoclonal antibody against tetrodotoxin (TTX), prepared by Kawatsu et al. (1997), has been used in several TTX-related studies. Herein, we confirmed the quite low cross-reactivity of this antibody to three major TTX analogues in pufferfish using competitive ELISA: 5,6,11-trideoxyTTX (
Keita, Yamaki, Kyoka, Sato, Yuta, Kudo, Yuko, Cho, Keiichi, Konoki, Tomohiro, Takatani, Osamu, Arakawa, Kentaro, Kawatsu, Mari, Yotsu-Yamashita   +8 more
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Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium (Anura: Brachycephalidae)

Toxicon, 2002
Brachycephalus ephippium is a diurnal frog, that shows aposematic colouration and inhabits Atlantic forest leaf litter in south-eastern Brazil. The presence of tetrodotoxin (TTX) in the skin, liver and ovaries of B. ephippium was demonstrated. The skin (260 M.U./g) exhibited the highest toxicity followed by liver (177 M.U./g).
Osmindo R, Pires, Antonio, Sebben, Elisabeth F, Schwartz, Simone W R, Largura, Carlos, Bloch, Rodrigo A V, Morales, Carlos A, Schwartz   +6 more
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Changes in Tissue Distribution of Tetrodotoxin and Its Analogues in Association with Maturation in the Toxic Flatworm, Planocera multitentaculata

Marine Biotechnology, 2022
The toxic flatworm, Planocera multitentaculata, possesses highly concentrated tetrodotoxin (TTX), also known as pufferfish toxin, throughout its life cycle, including the egg and larval stages. Additionally, TTX analogues, 5,6,11-trideoxyTTX and 11-norTTX-6(S)-ol, have also been detected in the flatworm.
Hikaru, Oyama, Masaaki, Ito, Rei, Suo, Naoko, Goto-Inoue, Mizuki, Morisasa, Tsukasa, Mori, Haruo, Sugita, Tetsushi, Mori, Ryota, Nakahigashi, Masaatsu, Adachi, Toshio, Nishikawa, Shiro, Itoi   +11 more
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