Results 141 to 150 of about 3,718 (180)
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Toxicon, 2003
11-oxoTTX is an analogue 4-5 times more toxic than TTX itself, been rare even in marine animals. Two ions at m/z 320 and 336 corresponding to TTX and 11-oxoTTX (M+H(+)), respectively, were detected in the Brachycephalidae frog Brachycephalus ephippium extracts.
Osmindo R, Pires +5 more
openaire +2 more sources
11-oxoTTX is an analogue 4-5 times more toxic than TTX itself, been rare even in marine animals. Two ions at m/z 320 and 336 corresponding to TTX and 11-oxoTTX (M+H(+)), respectively, were detected in the Brachycephalidae frog Brachycephalus ephippium extracts.
Osmindo R, Pires +5 more
openaire +2 more sources
Toxicon, 2005
Tetrodotoxin (TTX) is one of the most potent toxin already isolated, which occurs in a wide range of marine as well as terrestrial animals such as in newts and anurans. In this work, the occurrence of TTX and analogues was examined in three brachycephalid species: Brachycephalus ephippium, B. nodoterga and B. pernix using LC-FLD and LC-MS/MS.
Osmindo R, Pires +5 more
openaire +2 more sources
Tetrodotoxin (TTX) is one of the most potent toxin already isolated, which occurs in a wide range of marine as well as terrestrial animals such as in newts and anurans. In this work, the occurrence of TTX and analogues was examined in three brachycephalid species: Brachycephalus ephippium, B. nodoterga and B. pernix using LC-FLD and LC-MS/MS.
Osmindo R, Pires +5 more
openaire +2 more sources
Toxicon, 2007
Tetrodotoxin (TTX) and its analogue 6-epitetrodotoxin (6-epiTTX) were quantitatively assayed in 59 newts representing four Triturus species (Triturus alpestris, Triturus cristatus, Triturus helveticus, Triturus vulgaris) from southern Germany by a post-column fluorescent-HPLC system.
Mari, Yotsu-Yamashita +3 more
openaire +2 more sources
Tetrodotoxin (TTX) and its analogue 6-epitetrodotoxin (6-epiTTX) were quantitatively assayed in 59 newts representing four Triturus species (Triturus alpestris, Triturus cristatus, Triturus helveticus, Triturus vulgaris) from southern Germany by a post-column fluorescent-HPLC system.
Mari, Yotsu-Yamashita +3 more
openaire +2 more sources
Toxicon, 2001
Tetrodotoxin (TTX) and its analogue 6-epiTTX were detected in 11-12 specimens of the red-spotted newt, Notophthalmus viridescens, by a post-column fluorescent-HPLC system and by LC/MS in selected ion monitoring mode. TTX levels varied considerably among individuals from low (less than 0.15 microg TTX/g newt) to high concentrations (23.5 microg TTX/g ...
M, Yotsu-Yamashita, D, Mebs
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Tetrodotoxin (TTX) and its analogue 6-epiTTX were detected in 11-12 specimens of the red-spotted newt, Notophthalmus viridescens, by a post-column fluorescent-HPLC system and by LC/MS in selected ion monitoring mode. TTX levels varied considerably among individuals from low (less than 0.15 microg TTX/g newt) to high concentrations (23.5 microg TTX/g ...
M, Yotsu-Yamashita, D, Mebs
openaire +2 more sources
Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog
Chemistry – A European Journal, 2014AbstractThe first total synthesis of chiriquitoxin, the most structurally complex analogue of tetrodotoxin isolated from a Costa Rican dart frog, has been accomplished from a newly designed intermediate for a variety of tetrodotoxin derivatives. The synthesis includes the third total synthesis of tetrodotoxin in this laboratory, and its intermediate ...
Masaatsu, Adachi +5 more
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Food Additives & Contaminants: Part A, 2016
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Vaishali, Bane +4 more
openaire +2 more sources
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Vaishali, Bane +4 more
openaire +2 more sources
Toxicon, 2012
Efts and adult specimens (n = 142) of the red-spotted newt Notophthalmus viridescens from various locations in Canada and USA were analyzed for the presence of tetrodotoxin (TTX) and of its analogues 6-epitetrodotoxin and 11-oxotetrodotoxin. Considerable individual variations in toxin levels were found within and among populations from New Hampshire ...
Mari, Yotsu-Yamashita +8 more
openaire +2 more sources
Efts and adult specimens (n = 142) of the red-spotted newt Notophthalmus viridescens from various locations in Canada and USA were analyzed for the presence of tetrodotoxin (TTX) and of its analogues 6-epitetrodotoxin and 11-oxotetrodotoxin. Considerable individual variations in toxin levels were found within and among populations from New Hampshire ...
Mari, Yotsu-Yamashita +8 more
openaire +2 more sources
Toxicon, 2017
Tetrodotoxin (TTX) is a potent neurotoxin naturally found in terrestrial and marine animals targeting the voltage-gated sodium channels. Historically, TTX has raised food safety concerns mainly in the Asian countries due to the consumption of the typical pufferfish-derived delicacy fugu.
Luca Dellafiora +2 more
openaire +3 more sources
Tetrodotoxin (TTX) is a potent neurotoxin naturally found in terrestrial and marine animals targeting the voltage-gated sodium channels. Historically, TTX has raised food safety concerns mainly in the Asian countries due to the consumption of the typical pufferfish-derived delicacy fugu.
Luca Dellafiora +2 more
openaire +3 more sources
Toxicon, 2016
The voltage-gated sodium ion channel inhibitory activities of four tetrodotoxin analogues were evaluated for their ability to reduce the cytotoxicity of ouabain and veratridine in mouse neuroblastoma Neuro-2a cells. EC50 of the novel analogue, 4,4a-anhydrotetrodotoxin purified from pufferfish, was 750 fold larger than that of tetrodotoxin, supporting ...
Shogo, Saruhashi +2 more
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The voltage-gated sodium ion channel inhibitory activities of four tetrodotoxin analogues were evaluated for their ability to reduce the cytotoxicity of ouabain and veratridine in mouse neuroblastoma Neuro-2a cells. EC50 of the novel analogue, 4,4a-anhydrotetrodotoxin purified from pufferfish, was 750 fold larger than that of tetrodotoxin, supporting ...
Shogo, Saruhashi +2 more
openaire +2 more sources
ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Toshio Nishikawa +3 more
openaire +1 more source
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Toshio Nishikawa +3 more
openaire +1 more source