Results 131 to 140 of about 1,729 (152)
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Toxicon, 2012
Efts and adult specimens (n = 142) of the red-spotted newt Notophthalmus viridescens from various locations in Canada and USA were analyzed for the presence of tetrodotoxin (TTX) and of its analogues 6-epitetrodotoxin and 11-oxotetrodotoxin. Considerable individual variations in toxin levels were found within and among populations from New Hampshire ...
Mari Yotsu-Yamashita +2 more
exaly +3 more sources
Efts and adult specimens (n = 142) of the red-spotted newt Notophthalmus viridescens from various locations in Canada and USA were analyzed for the presence of tetrodotoxin (TTX) and of its analogues 6-epitetrodotoxin and 11-oxotetrodotoxin. Considerable individual variations in toxin levels were found within and among populations from New Hampshire ...
Mari Yotsu-Yamashita +2 more
exaly +3 more sources
Toxicon, 2022
Tetrodotoxins (TTXs) were investigated in two local pufferfish species, Diodon hystrix and Arothron hispidus, from Mozambican coast. TTX and analogues 4-epiTTX, 4,9-anhydroTTX, 11-deoxyTTX, and 11-norTTX-6-(R/S)-ol were found in both species and high level of TTX was found in A. hispidus (9522.0 μg TTX kg-1) than in D. hystrix (350.9 μg TTX kg-1).
Isidro José Tamele +3 more
openaire +2 more sources
Tetrodotoxins (TTXs) were investigated in two local pufferfish species, Diodon hystrix and Arothron hispidus, from Mozambican coast. TTX and analogues 4-epiTTX, 4,9-anhydroTTX, 11-deoxyTTX, and 11-norTTX-6-(R/S)-ol were found in both species and high level of TTX was found in A. hispidus (9522.0 μg TTX kg-1) than in D. hystrix (350.9 μg TTX kg-1).
Isidro José Tamele +3 more
openaire +2 more sources
Toxicon, 2001
Tetrodotoxin (TTX) and its analogue 6-epiTTX were detected in 11-12 specimens of the red-spotted newt, Notophthalmus viridescens, by a post-column fluorescent-HPLC system and by LC/MS in selected ion monitoring mode. TTX levels varied considerably among individuals from low (less than 0.15 microg TTX/g newt) to high concentrations (23.5 microg TTX/g ...
M, Yotsu-Yamashita, D, Mebs
openaire +2 more sources
Tetrodotoxin (TTX) and its analogue 6-epiTTX were detected in 11-12 specimens of the red-spotted newt, Notophthalmus viridescens, by a post-column fluorescent-HPLC system and by LC/MS in selected ion monitoring mode. TTX levels varied considerably among individuals from low (less than 0.15 microg TTX/g newt) to high concentrations (23.5 microg TTX/g ...
M, Yotsu-Yamashita, D, Mebs
openaire +2 more sources
Toxicon, 2016
The voltage-gated sodium ion channel inhibitory activities of four tetrodotoxin analogues were evaluated for their ability to reduce the cytotoxicity of ouabain and veratridine in mouse neuroblastoma Neuro-2a cells. EC50 of the novel analogue, 4,4a-anhydrotetrodotoxin purified from pufferfish, was 750 fold larger than that of tetrodotoxin, supporting ...
Keiichi Konoki, Mari Yotsu-Yamashita
exaly +3 more sources
The voltage-gated sodium ion channel inhibitory activities of four tetrodotoxin analogues were evaluated for their ability to reduce the cytotoxicity of ouabain and veratridine in mouse neuroblastoma Neuro-2a cells. EC50 of the novel analogue, 4,4a-anhydrotetrodotoxin purified from pufferfish, was 750 fold larger than that of tetrodotoxin, supporting ...
Keiichi Konoki, Mari Yotsu-Yamashita
exaly +3 more sources
Food Additives & Contaminants: Part A, 2016
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Vaishali, Bane +4 more
openaire +2 more sources
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Vaishali, Bane +4 more
openaire +2 more sources
Toxicon, 2007
Tetrodotoxin (TTX) and its analogue 6-epitetrodotoxin (6-epiTTX) were quantitatively assayed in 59 newts representing four Triturus species (Triturus alpestris, Triturus cristatus, Triturus helveticus, Triturus vulgaris) from southern Germany by a post-column fluorescent-HPLC system.
Mari, Yotsu-Yamashita +3 more
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Tetrodotoxin (TTX) and its analogue 6-epitetrodotoxin (6-epiTTX) were quantitatively assayed in 59 newts representing four Triturus species (Triturus alpestris, Triturus cristatus, Triturus helveticus, Triturus vulgaris) from southern Germany by a post-column fluorescent-HPLC system.
Mari, Yotsu-Yamashita +3 more
openaire +2 more sources
ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Toshio Nishikawa +3 more
openaire +1 more source
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Toshio Nishikawa +3 more
openaire +1 more source
Toxicon, 2003
An analogue of tetrodotoxin (TTX), 11-oxoTTX, was semi-purified from the red-spotted newt, Notophthalmus viridescens, and identified by ESI-MS and 1H NMR spectra. The levels of TTX, 11-oxoTTX and 6-epiTTX in early stage of development (efts) of this newt were investigated by a post-column fluorescent-HPLC system, and compared with those of adult newts.
Mari Yotsu-Yamashita
exaly +3 more sources
An analogue of tetrodotoxin (TTX), 11-oxoTTX, was semi-purified from the red-spotted newt, Notophthalmus viridescens, and identified by ESI-MS and 1H NMR spectra. The levels of TTX, 11-oxoTTX and 6-epiTTX in early stage of development (efts) of this newt were investigated by a post-column fluorescent-HPLC system, and compared with those of adult newts.
Mari Yotsu-Yamashita
exaly +3 more sources
Food Chemistry
Tetrodotoxin (TTX) is a potent neurotoxin found at high concentrations in pufferfish Takifugu pardalis. Despite its common consumption in Korea, few studies have examined seasonal variations in TTX and its analogues. This study investigated seasonal changes in TTX and its analogue composition in Korean T.
Bong Ki, Park +6 more
openaire +2 more sources
Tetrodotoxin (TTX) is a potent neurotoxin found at high concentrations in pufferfish Takifugu pardalis. Despite its common consumption in Korea, few studies have examined seasonal variations in TTX and its analogues. This study investigated seasonal changes in TTX and its analogue composition in Korean T.
Bong Ki, Park +6 more
openaire +2 more sources
Scalable Synthesis of a New Dihydroxylated Intermediate for Tetrodotoxin and Its Analogues
Synthesis, 2010Minoru Isobe +4 more
openaire +1 more source