Results 171 to 180 of about 25,457 (196)

Acute cardiovascular, antiarrhythmic and toxic effects of tetrodotoxin (TTX) in unanesthetized dogs

Toxicology and Applied Pharmacology, 1972
Abstract Five unanesthetized dogs were given iv doses of 0.3, 0.6, 1.2, 2.4 and 4.8 μg/kg of TTX infused over 5 min periods at 65 min intervals. In similar experiments 4 anesthetized dogs were given serial doses of saline. Emesis occurred in 3 or 4 dogs after each dose of TTX, and the highest dose produced respiratory arrest and death in 4 of the 5 ...
B R, Duce, H S, Feldman, E R, Smith
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Detection of tetrodotoxin (TTX) from two copepods infecting the grass puffer Takifugu niphobles: TTX attracting the parasites?

Toxicon, 2006
In May 2002, two parasitic copepods, Pseudocaligus fugu and Taeniacanthus sp., were collected from the body surface and gill of the grass puffer Takifugu niphobles, respectively, in Takehara city, Hiroshima Prefecture, faced with Seto Inland Sea located in the western part of Japan.
Katsutoshi, Ito, Shinya, Okabe, Manabu, Asakawa, Kentaro, Bessho, Shigeto, Taniyama, Yasuo, Shida, Susumu, Ohtsuka   +6 more
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First identification of tetrodotoxin (TTX) in the flatworm Stylochoplana sp.; a source of TTX for the sea slug Pleurobranchaea maculata

Toxicon, 2015
High concentrations of the neurotoxin tetrodotoxin (TTX) were detected by liquid chromatography-mass spectrometry (LC-MS) in the Platyhelminthes Stylochoplana sp. from Pilot Bay (Tauranga, New Zealand). This is the first detection of TTX in this genus. Concentrations were monitored from March to November (2013) and found to significantly decrease from ...
Lauren Salvitti, Susanna A. Wood, David I. Taylor, Paul McNabb, S. Craig Cary   +4 more
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Quantitative detection of tetrodotoxin (TTX) by a surface plasmon resonance (SPR) sensor

Sensors and Actuators B: Chemical, 2008
Abstract We report the quantitative antibody-based detection of a low-molecular weight molecule tetrodotoxin (TTX) (∼319 Da) by inhibition assay with a surface plasmon resonance (SPR) sensor. A novel anti-TTX antibody sensing surface was developed by chemically immobilizing TTX on a gold film with a mixed self assembled monolayer (SAM) consisting of ...
A TAYLOR, J LADD, S ETHERIDGE, J DEEDS, S HALL, S JIANG   +5 more
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Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels

The Journal of Pharmacology and Experimental Therapeutics, 2007
The excitability of sensory neurons depends on the expression of various voltage-gated Na+ channel isoforms. The tetrodotoxin-resistant (TTXr) Na+ channel Na(v)1.8 accounts for the electroresponsiveness of nociceptive neurons and contributes to inflammatory and neuropathic pain.
Andreas, Leffler, Anne, Reiprich, Durga P, Mohapatra, Carla, Nau   +3 more
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THE SCENT OF DANGER: TETRODOTOXIN (TTX) AS AN OLFACTORY CUE OF PREDATION RISK

Ecological Monographs, 2006
Larvae of the California newt (Taricha torosa) exhibit striking predator-avoidance behavior, escaping to refuges in response to a chemical cue from cannibalistic adults. In laboratory flow-tank experiments, stream water collected near free-ranging adults induced hiding responses in 100% of the larvae tested.
Richard K. Zimmer, Daniel W. Schar, Ryan P. Ferrer, Patrick J. Krug, Lee B. Kats, William C. Michel   +5 more
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High-resolution mass spectrometry analysis of tetrodotoxin (TTX) and its analogues in puffer fish and shellfish

Food Additives & Contaminants: Part A, 2016
Tetrodotoxin (TTX) is an emerging toxin in the European marine environment. It has various known structural analogues. It acts as a sodium channel blocker; the ability of each analogue to bind to the sodium channel varies with the particular structure of each analogue. Thus, each analogue will vary in its toxic potential. TTX analogues co-occur in food
Vaishali, Bane, Brid, Brosnan, Paul, Barnes, Mary, Lehane, Ambrose, Furey   +4 more
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Intracellular visualization of tetrodotoxin (TTX) in the skin of a puffer Tetraodon nigroviridis by immunoenzymatic technique

Toxicon, 2003
Micro-distributions of tetrodotoxin (TTX) in the skin of a brackish-water puffer Tetraodon nigroviridis were investigated by means of a monoclonal anti-TTX antibody under light and transmission electron microscope. In light microscopy TTX antigen was visualized as brown color in undifferentiated basal cells and succiform cells of the skin, while in ...
Yahia, Mahmud, Osamu, Arakawa, Akitoyo, Ichinose, Mohosena, Begum Tanu, Tomohiro, Takatani, Kazumi, Tsuruda, Kentaro, Kawatsu, Yonekazu, Hamano, Tamao, Noguchi   +8 more
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Mechanism of Action of Tetrodotoxin (TTX) and Saxitoxin (STX)

1971
Marine toxins such as TTX and STX have aroused the interest of physiologists, biochemists, pharmacologists, and biological warfare people, as well as writers of spy and mystery stories. In the hands of the neuroscientist they have been turned into helpful instruments vital for the study of nerve function and excitable membranes.
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Effect of tetrodotoxin (TTX) on some brain neurotransmitters in rats.

Journal of natural toxins, 2002
Tetrodotoxin (TTX) is a potent marine neurotoxin named after the order of fish from which it is most commonly associated, the Tetraodontiforms, or the tetraodon pufferfish. In the present study the crude TTX was extracted from pufferfish Lagocephalus sceleratus collected from the Red Sea in Egypt.
Z A, Zaki, E A, Mady, S M, Ahmed, N M, Youssef   +3 more
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