Results 191 to 200 of about 15,357 (224)

Advances in the treatment of age-related hearing loss: from molecular mechanisms to targeted interventions. [PDF]

Front Aging Neurosci
Mao L, Ma S, Zhu K, Feng C, Chen X, Yang F, Duan M, Chen X.   +7 more
europepmc   +1 more source

Low Shear Stress Promotes Atherosclerosis by Mediating Pathological Accumulation of Endothelial Lipid Droplets via the KLF4/TFEB/ATP1A1 Axis. [PDF]

J Cardiovasc Dev Dis
Shi Y, Tan YN, Wu LD, Wang LG, Gu Y, Zhou WY, Shao MQ, Zhang JX.   +7 more
europepmc   +1 more source

Restoration of impaired lysosomal function mitigates drusen-like deposit formation and cell death in Malattia Leventinese. [PDF]

JCI Insight
Inoue Y, Ikeda HO, Hata M, Iida Y, Okamoto-Furuta K, Asaka I, Arita M, Tsujikawa A.   +7 more
europepmc   +1 more source

Syntaxin 12 Sustains Endosomal-Lysosomal Homeostasis and Survival in Glioblastoma Stem-Like Cells. [PDF]

Traffic
Maghe C, Barbach A, André-Grégoire G, Renaud CCN, Le Guyon M, Moreau R, Bidère N, Gavard J.   +7 more
europepmc   +1 more source

Circadian regulation of osteoclast lysosomal-resorption machinery: implications for osteoporosis therapy. [PDF]

Front Cell Dev Biol
Zhou C, Tang Y, Zeng L, Xu S, Xiang Y, Ning K, Zhang S, Peng S, Chen S, Liu H, Zhang G.   +10 more
europepmc   +1 more source

VPS13B maintains lysosomal homeostasis through regulation of TFEB. [PDF]

Mol Brain
Lee SK, Park S, Yeom MY, Lee JA.
europepmc   +1 more source

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Monitoring TFEB translocation

2021
The transcription factor EB (TFEB) plays a critical role in autophagy induction and lysosomal biogenesis by orchestrating the expression of autophagy- and lysosome-related genes. In response to a series of stresses such as nutrient starvation, TFEB translocates from the cytoplasm to the nucleus, where it exerts its regulatory function.
Guo, Chen, Chenglong, Mu, Yanfang, Chen, Na, An, Yushan, Zhu, Oliver, Kepp, Guido, Kroemer   +6 more
openaire   +2 more sources

TFEB – at the crossroads of host–pathogen interactions

Journal of Cell Science, 2021
ABSTRACT The existence of constantly evolving dynamic interactions between the host and the pathogen determines their fate in this continuous arms race. Hence, identifying the molecular basis of processes that reinforce host defensive strategies to eliminate intracellular pathogens is of utmost significance.
null Keerti, Aarti Pant, Ravi Manjithaya
openaire   +2 more sources

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective [PDF]

Trends in Neurosciences, 2016
The autophagy-lysosomal pathway (ALP) is involved in the degradation of long-lived proteins. Deficits in the ALP result in protein aggregation, the generation of toxic protein species, and accumulation of dysfunctional organelles, which are hallmarks of Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and prion disease ...
Hui Zheng, Yin Xu, Andrea Ballabio
exaly   +4 more sources

TRPML1 and TFEB, an Intimate Affair

2022
Ca2+ is a universal second messenger that plays a wide variety of fundamental roles in cellular physiology. Thus, to warrant selective responses and to allow rapid mobilization upon specific stimuli, Ca2+ is accumulated in organelles to keep it at very low levels in the cytoplasm during resting conditions.
openaire   +3 more sources