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Non-canonical roles of ATG8 for TFEB activation
Biochemical Society Transactions, 2022Autophagy is an evolutionally conserved cytoplasmic degradation pathway in which the double membrane structure, autophagosome sequesters cytoplasmic material and delivers them to lysosomes for degradation. Many autophagy related (ATG) proteins participate in the regulation of the several steps of autophagic process.
Shuhei Nakamura +2 more
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TFEB: a double-edged sword for tumor metastasis
Journal of Molecular Medicine, 2023Transcription factor EB, a member of the microphthalmia-associated transcription factor (MiTF/TFE) family, is a master regulator of autophagy, lysosome biogenesis, and TAMs. Metastasis is one of the main reasons for the failure of tumor therapy. Studies on the relationship between TFEB and tumor metastasis are contradictory.
Jun-Hu Hu +12 more
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Protected from atherosclerosis by TFEB
Science, 2017Vascular Biology Atherosclerosis, or the buildup of fatty plaques in blood vessels, can lead to high blood pressure and heart attacks. Lu et al. found that in cultured endothelial cells, the transcription factor TFEB reduced oxidative stress and inflammation, processes that contribute to ...
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Ca2+-Dependent Regulation of TFEB and Lysosomal Function
2019Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions like lysosomal exocytosis.
Di Paola, Simone, Medina, DL
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Improving metabolism with TFEB
Science, 2019Metabolism TFEB is a transcription factor best known for its role in transcriptionally activating genes encoding autophagy factors. Evans et al. found that mice over-expressing TFEB in adipocytes were protected from the adverse metabolic consequences of a high-fat diet.
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TFEB controls syncytiotrophoblast differentiation
Abstract During human development, a subset of differentiating fetal cells form a temporary organ, the placenta, which invades the uterine wall to support nutrient, oxygen, and waste exchange between the mother and fetus until birth.Meagan N. Esbin +6 more
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TFEB Supports Pancreatic Cancer Growth through the Transcriptional Regulation of Glutaminase
Cancers, 2021Kyung-Chul Choi +2 more
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Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB
EMBO Reports, 2020Zhiyuan You, Yusha Wang, Chao Peng
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TFEB; Beyond Its Role as an Autophagy and Lysosomes Regulator
Cells, 2022Daniel Ortega-Cuellar +2 more
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