Results 61 to 70 of about 3,329 (168)

Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations. [PDF]

PLoS ONE, 2017
Tenofovir alafenamide (TAF) is a phosphonoamidate prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV). TAF is approved for the treatment of HIV-1 infection as part of the single-tablet regimen containing elvitegravir, cobicistat,
Christian Callebaut, Yang Liu, Darius Babusis, Adrian Ray, Michael Miller, Kathryn Kitrinos   +5 more
doaj   +1 more source

Chronic Pain as an Early Diagnostic Clue in Hereditary Multiple Exostoses: Two Pediatric Cases Highlighting Diagnostic Delay

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Hereditary multiple exostoses (HME) is a rare autosomal dominant skeletal disorder characterized by the development of multiple osteochondromas adjacent to the growth plates. Although skeletal deformities and palpable masses are common findings, chronic pain may represent an early and underappreciated diagnostic clue, particularly in pediatric
Melissa Mariti Fraga, Valesca Oliveira Paes Tanaka, Luciana Tudech Salgueiro Pedro Paulo, Maria Carolina Santos, Carolina Costa Figueiredo, Nara Michelle de Araújo Evangelista, Vânia de Fátima Tonetto Fernandes, Guido de Paula Colares Neto   +7 more
wiley   +1 more source

Correlation between compartmental tenofovir concentrations and an ex vivo rectal biopsy model of tissue infectibility in the RMP-02/MTN-006 phase 1 study. [PDF]

PLoS ONE, 2014
This study was designed to assess the dose-response relationship between tissue, blood, vaginal and rectal compartment concentrations of tenofovir (TFV) and tenofovir diphosphate (TFVdp) and ex vivo rectal HIV suppression following oral tenofovir ...
Nicola Richardson-Harman, Craig W Hendrix, Namandjé N Bumpus, Christine Mauck, Ross D Cranston, Kuo Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela Kashuba, Peter A Anton   +10 more
doaj   +1 more source

Temperature effects from hydropeaking impair egg and larval development in Danube salmon Hucho hucho and brown trout Salmo trutta

Journal of Fish Biology, Volume 109, Issue 2, Page 1312-1316, August 2026.
Abstract Hydropeaking is considered an important stressor for salmonids and other species in rivers affected by hydropower. In this study, we investigated the in situ effects of hydropeaking on the survival of eggs and larvae of fall spawning brown trout as well as spring spawning Danube salmon.
Julius Gorenz, Elisabeth Winter, Joachim Pander, Juergen Geist   +3 more
wiley   +1 more source

TFV as a strategic tool

, 2011
The paper investigates the use of the Transformation-Flow-Value theory as a strategic tool in the development of the project production firm. When producing products such as ships, focus on value more than on cost may be the best approach, but in service industries such as construction, focus on flow may often be a far better approach than just looking
Bonke, Sten, Bertelsen, Sven
openaire   +1 more source

Total protein, albumin and low-molecular-weight protein excretion in HIV-positive patients

BMC Nephrology, 2012
Background Chronic kidney disease is common in HIV positive patients and renal tubular dysfunction has been reported in those receiving combination antiretroviral therapy (cART).
Campbell Lucy J, Dew Tracy, Salota Rashim, Cheserem Emily, Hamzah Lisa, Ibrahim Fowzia, Sarafidis Pantelis A, Moniz Caje F, Hendry Bruce M, Poulton Mary, Sherwood Roy A, Post Frank A   +11 more
doaj   +1 more source

Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence

EClinicalMedicine, 2018
Background: Pharmacologic adherence measures were critical to the interpretation of the tenofovir (TFV)-disoproxil-fumarate/emtricitabine (TDF/FTC) PrEP trials.
Monica Gandhi, Peter Bacchetti, Warren C. Rodrigues, Matthew Spinelli, Catherine A. Koss, Paul K. Drain, Jared M. Baeten, Nelly R. Mugo, Kenneth Ngure, Leslie Z. Benet, Hideaki Okochi, Guohong Wang, Michael Vincent   +12 more
doaj   +1 more source

Prevotella bivia Influences Antiretroviral Pharmacokinetics and Viral Replication in an Ex Vivo Vaginal Tissue Model

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT The vaginal microbiome plays a complex role in tenofovir's mucosal pharmacology. While the relative contribution of systemic versus local concentrations to PrEP PK/PD is an ongoing debate, the development of effective HIV prevention requires an understanding of events at the site of transmission.
Alyssa M. Lantz, Lindsey B. Collins, Elizabeth B. Hirsch, Christopher Staley, Melanie R. Nicol   +4 more
wiley   +1 more source

Social Representations of Bedside Milk Expression Among Mothers of Preterm Newborns in Neonatal Intensive Care Units

Journal of Advanced Nursing, Volume 82, Issue 6, Page 6362-6372, June 2026.
ABSTRACT Aim To understand the social representations of bedside milk expression (BME) among mothers of preterm newborns in neonatal intensive care units (NICUs). Design Qualitative descriptive study. Methods The study was conducted from July to August 2024 in two NICUs of a referral maternity hospital in Fortaleza, Brazil.
Ana Karen de Sousa Alves, Ana Paula Melo Façanha, Elaine Meireles Castro, Keline Soraya Santana Nobre, Flávia Vasconcelos Teixeira, Maria Milena Farias de Souza Castro, José Mateus Pires, Victórya Suéllen Maciel Abreu, Priscila de Souza Aquino   +8 more
wiley   +1 more source

Veri Zarflama Analizi (VZA) ve Malmquist Toplam Faktör Verimliliği (TFV): Konaklama İşletmelerinde Bir Uygulama [PDF]

Ege Akademik Bakis (Ege Academic Review), 2012
Global dunyada yogun rekabet kendini gostermektedir. Bu surecte hemen hemen butun ekonomilerin, kurumlarin, toplumlarin ve bireylerin yuksek rekabet kulturune uygun davranmasi zorunlu olmaktadir. Konaklama isletmelerinin etkinligi ve verimliligi ise yogun rekabet ortaminda cok daha onemli hale gelmektedir.
openaire   +3 more sources