Results 61 to 70 of about 4,308 (211)
Frontiers in Nanotechnology, 2023 This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS).
Marguerite R. Butler +7 more
doaj +1 more source
Brain Pathology, EarlyView.Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma +12 more
wiley +1 more source
Pharmacokinetic model of TFV and intracellular TFV-DP and model of viral kinetics.
, 2012 A: Pharmacokinetic model. Parameters and are the absorption and elimination rate constants of the central compartment C1 (which resembles plasma pharmacokinetics of TFV) respectively. The parameters and denote the influx and outflux rate constant to-/
Sulav Duwal (152805) +2 more
core +1 more source
A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel. [PDF]
PLoS ONE, 2011 Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical.Forty-nine participants entered a two-phase study: single-dose ...
Jill L Schwartz +6 more
doaj +1 more source
Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease
Life, 2023 This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study.
Hung-Yin Lai +4 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Background The effect of tenofovir disoproxil fumarate (TDF) when used as pre‐exposure prophylaxis (PrEP) on renal function in pregnant and postpartum women is understudied. An open‐label clinical trial (CAP016 study) was designed to examine the safety of TDF‐PrEP use during pregnancy and breastfeeding.
Gaysheen Kistan +5 more
wiley +1 more source
ACS Omega, 2023 Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent ...
Marguerite R. Butler +4 more
openaire +4 more sources
TFV quantification from rectal sponges is predictive of plasma TFV exposure during rectal dosing.
, 2014 Plasma TFV exposure is correlated linearly with rectal sponge TFV exposure ...
Kuo-Hsiung Yang (650738) +10 more
core +1 more source
JCI Insight, 2022 In spite of the rollout of oral pre-exposure prophylaxis (PrEP), the rate of new HIV infections remains a major health crisis. In the United States, new infections occur predominantly in men having sex with men (MSM) in rural settings where access to ...
Peng Xiao +13 more
doaj +1 more source
Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations. [PDF]
PLoS ONE, 2017 Tenofovir alafenamide (TAF) is a phosphonoamidate prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV). TAF is approved for the treatment of HIV-1 infection as part of the single-tablet regimen containing elvitegravir, cobicistat,
Christian Callebaut +5 more
doaj +1 more source