Results 41 to 50 of about 412 (125)

Single‐Stage Anatomic Reconstruction of Anterior Cruciate Ligament, Posterior Cruciate Ligament, Medial Collateral Ligament, and Posterolateral Corner for Multiligament Knee Injury

Arthroscopy Techniques, Volume 15, Issue 8, August 2026.
Abstract Multiligament knee injuries represent rare and challenging injuries that require complex surgical management to restore stability and function. Current evidence supports anatomic single‐stage reconstructions when feasible in order to re‐establish knee kinematics and enable early rehabilitation.
Logan D. Moews, Joseph C. Brinkman, Felipe Casanova, Napatpong Thamrongskulsiri, Jacob T. Morgan, Tomas F. Vega, Jorge Chahla   +6 more
wiley   +1 more source

Hypo-osmolar rectal douche tenofovir formulation prevents simian/human immunodeficiency virus acquisition in macaques

JCI Insight, 2022
In spite of the rollout of oral pre-exposure prophylaxis (PrEP), the rate of new HIV infections remains a major health crisis. In the United States, new infections occur predominantly in men having sex with men (MSM) in rural settings where access to ...
Peng Xiao, Sanjeev Gumber, Mark A. Marzinke, Thuy Hoang, Rohan Myers, Abhijit A. Date, Justin Hanes, Laura M. Ensign, Lin Wang, Lisa C. Rohan, Richard Cone, Edward J. Fuchs, Craig W. Hendrix, Francois Villinger   +13 more
doaj   +1 more source

A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel. [PDF]

PLoS ONE, 2011
Tenofovir (TFV) gel is being evaluated as a microbicide with pericoital and daily regimens. To inhibit viral replication locally, an adequate concentration in the genital tract is critical.Forty-nine participants entered a two-phase study: single-dose ...
Jill L Schwartz, Wes Rountree, Angela D M Kashuba, Vivian Brache, Mitchell D Creinin, Alfred Poindexter, Brian P Kearney   +6 more
doaj   +1 more source

Detection and quantification of antiviral drug tenofovir using silver nanoparticles and surface enhanced Raman spectroscopy (SERS) with spatially resolved hotspot selection

Frontiers in Nanotechnology, 2023
This study introduces a convenient and ultra-sensitive method of detection and quantification of the antiviral drug, tenofovir (TFV), by surface-enhanced Raman spectroscopy (SERS).
Marguerite R. Butler, Jana Hrncirova, Jana Hrncirova, Terry A. Jacot, Sucharita Dutta, Meredith R. Clark, Gustavo F. Doncel, John B. Cooper   +7 more
doaj   +1 more source

Arthroscopic Repair of the Anterior Root of the Lateral Meniscus Using Knotless All‐Suture Anchors

Arthroscopy Techniques, Volume 15, Issue 8, August 2026.
Abstract Anterior root tears of the lateral meniscus are uncommon but can significantly disrupt knee biomechanics by increasing contact pressures and accelerating cartilage degeneration if left untreated. This article describes an arthroscopic technique for repair of the anterior root of the lateral meniscus using all‐suture anchors.
Tanner Nishioka, Napatpong Thamrongskulsiri, Jacob T. Morgan, Tomás F. Vega, Felipe Casanova, Logan D. Moews, Jorge Chahla   +6 more
wiley   +1 more source

Viability of primary osteoblasts after treatment with tenofovir alafenamide: Lack of cytotoxicity at clinically relevant drug concentrations. [PDF]

PLoS ONE, 2017
Tenofovir alafenamide (TAF) is a phosphonoamidate prodrug of the nucleotide HIV reverse transcriptase inhibitor tenofovir (TFV). TAF is approved for the treatment of HIV-1 infection as part of the single-tablet regimen containing elvitegravir, cobicistat,
Christian Callebaut, Yang Liu, Darius Babusis, Adrian Ray, Michael Miller, Kathryn Kitrinos   +5 more
doaj   +1 more source

Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease

Life, 2023
This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study.
Hung-Yin Lai, Alexander Chen, Po-Chiung Fang, Hun-Ju Yu, Ming-Tse Kuo   +4 more
doaj   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2949-2959, August 2026.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

Quantification of Antiviral Drug Tenofovir (TFV) by Surface-Enhanced Raman Spectroscopy (SERS) Using Cumulative Distribution Functions (CDFs)

ACS Omega, 2023
Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive spectroscopic technique that generates signal-enhanced fingerprint vibrational spectra of small molecules. However, without rigorous control of SERS substrate active sites, geometry, surface area, or surface functionality, SERS is notoriously irreproducible, complicating the consistent ...
Marguerite R. Butler, Jana Hrncirova, Meredith Clark, Sucharita Dutta, John B. Cooper   +4 more
openaire   +4 more sources

The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study

Retrovirology, 2009
Background Tenofovir disoproxil fumarate (TDF), emtricitabine (FTC), and efavirenz (EFV) are the three components of the once-daily, single tablet regimen (Atripla) for treatment of HIV-1 infection.
Svarovskaia Evguenia S, White Kirsten L, Goodman Derrick, Myrick Florence, Ly John K, Feng Joy Y, Borroto-Esoda Katyna, Miller Michael D   +7 more
doaj   +1 more source