Results 31 to 40 of about 4,308 (211)

Randomized, placebo controlled phase I trial of safety, pharmacokinetics, pharmacodynamics and acceptability of tenofovir and tenofovir plus levonorgestrel vaginal rings in women.

PLoS ONE, 2018
To prevent the global health burdens of human immunodeficiency virus [HIV] and unintended/mistimed pregnancies, we developed an intravaginal ring [IVR] that delivers tenofovir [TFV] at ~10mg/day alone or with levonorgestrel [LNG] at ~20μg/day for 90 days.
Andrea Ries Thurman, Jill L Schwartz, Vivian Brache, Meredith R Clark, Timothy McCormick, Neelima Chandra, Mark A Marzinke, Frank Z Stanczyk, Charlene S Dezzutti, Sharon L Hillier, Betsy C Herold, Raina Fichorova, Susana N Asin, Christiane Rollenhagen, Debra Weiner, Patrick Kiser, Gustavo F Doncel   +16 more
doaj   +1 more source

Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates. [PDF]

PLoS ONE, 2016
The coformulation of the nucleos(t)ide analogs (NA) tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC) is approved for HIV-infection treatment and prevention. Plasma TFV and FTC undergo complicated hybrid processes to form, accumulate, and
Xinhui Chen, Sharon M Seifert, Jose R Castillo-Mancilla, Lane R Bushman, Jia-Hua Zheng, Jennifer J Kiser, Samantha MaWhinney, Peter L Anderson   +7 more
doaj   +1 more source

Review Article: Renal Safety Profiles of Tenofovir Alafenamide, Tenofovir Disoproxil Fumarate, and Entecavir for the Treatment of Chronic Hepatitis B Infection-General and Special Populations. [PDF]

Aliment Pharmacol Ther
Current first‐line NUCs show comparable renal safety profiles in CHB patients with no or mild kidney dysfunction, with growing evidence that favours TAF. Future prospective studies are needed to validate these findings, and more research should focus on CHB patients with diabetes mellitus who are at risk of CKD.
Mak LY, Hu TH, Yap DYH.
europepmc   +2 more sources

Benchmarking of productivity of international tourism destinations with Malmquist-TFV index

Journal of Tourism Theory and Research, 2018
Son yıllarda turizm sektöründe mikro düzeyde verimlilik ve etkinlik ölçümü önemli bir araştırma konusu olmasına rağmen, makro düzeyde çok az araştırma bulunmaktadır. Bu nedenle çalışmada uluslararası turizm destinasyonlarının turizm sektörü etkinliğini ve verimliliğini karşılaştırmak, bunun için bir metodoloji oluşturmak amaçlanmaktadır.
GÖRAL, Ramazan, UYGUR, Akyay
openaire   +3 more sources

PCM-TV-TFV: A Novel Two-Stage Framework for Image Reconstruction from Fourier Data [PDF]

SIAM Journal on Imaging Sciences, 2017
We propose in this paper a novel two-stage Projection Correction Modeling (PCM) framework for image reconstruction from (non-uniform) Fourier measurements. PCM consists of a projection stage (P-stage) motivated by the multi-scale Galerkin method and a correction stage (C-stage) with an edge guided regularity fusing together the advantages of total ...
Weihong Guo, Guohui Song, Yue Zhang 0036
openaire   +2 more sources

Drug-level feedback counseling messages and corresponding TFV-DP thresholds.

, 2022
“Sample month” refers to the month when the TFV-DP sample was collected. “Results month” refers to the month when the results were given to the participant (e.g., for blood samples drawn at the Month 2 visit, TFV-DP results were reported to participants ...
Jennifer F. Morton (10263020), Nomhle Khoza (8066843), Jeanne Omony (12413215), Deborah Donnell (129620), Nicole Poovan (12413209), Jared M. Baeten (7339658), Edwin Mkwanazi (12413218), Sybil Hosek (10994537), Connie Celum (192996), Cole Grabow (12413221), Sinead Delany-Moretlwe (230038), Jennifer Velloza (12413206), Richard Munthali (4061725), Nontokozo Ndlovu (12413212)   +13 more
core   +1 more source

Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen. [PDF]

PLoS ONE, 2012
BACKGROUND: Daily pre-exposure prophylaxis (PrEP) with Truvada (a combination of emtricitabine (FTC) and tenofovir (TFV) disoproxil fumarate (TDF)) is a novel HIV prevention strategy recently found to prevent HIV transmission in men who have sex with men
Jessica Radzio, Wutyi Aung, Angela Holder, Amy Martin, Elizabeth Sweeney, James Mitchell, Shanon Bachman, Chou-Pong Pau, Walid Heneine, J Gerardo García-Lerma   +9 more
doaj   +1 more source

Diagnostic accuracy of a point‐of‐care urine tenofovir assay, and associations with HIV viraemia and drug resistance among people receiving dolutegravir and efavirenz‐based antiretroviral therapy

Journal of the International AIDS Society, 2023
Introduction Novel point‐of‐care assays which measure urine tenofovir (TFV) concentrations may have a role in improving adherence monitoring for people living with HIV (PLHIV) receiving antiretroviral therapy (ART).
Jienchi Dorward, Richard Lessells, Katya Govender, Pravi Moodley, Natasha Samsunder, Yukteshwar Sookrajh, Phil Turner, Christopher C. Butler, Gail Hayward, Monica Gandhi, Paul K. Drain, Nigel Garrett   +11 more
doaj   +1 more source

Infant lung function: criteria for selecting tidal flow–volume loops

ERJ Open Research, 2022
Background Tidal flow–volume (TFV) loops are commonly recorded in infants during sleep, due to the more regular breathing patterns compared to the awake state. Standardised deselection of loops outside pre-specified ranges are based on periods of regular
Karen Eline Stensby Bains, Hrefna Katrín Gudmundsdóttir, Martin Färdig, Erik Amnö, Christine M. Jonassen, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Corina Silvia Rueegg, Riyas Vettukattil, Karin C. Lødrup Carlsen   +10 more
doaj   +1 more source

Linking the Population Pharmacokinetics of Tenofovir and Its Metabolites With Its Cellular Uptake and Metabolism

CPT: Pharmacometrics & Systems Pharmacology, 2014
Empirical pharmacokinetic models are used to explain the pharmacokinetics of the antiviral drug tenofovir (TFV) and its metabolite TFV diphosphate (TFV‐DP) in peripheral blood mononuclear cells.
K Madrasi, R N Burns, C W Hendrix, M J Fossler, A Chaturvedula   +4 more
doaj   +1 more source