Results 31 to 40 of about 3,329 (168)

Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen. [PDF]

PLoS ONE, 2012
BACKGROUND: Daily pre-exposure prophylaxis (PrEP) with Truvada (a combination of emtricitabine (FTC) and tenofovir (TFV) disoproxil fumarate (TDF)) is a novel HIV prevention strategy recently found to prevent HIV transmission in men who have sex with men
Jessica Radzio, Wutyi Aung, Angela Holder, Amy Martin, Elizabeth Sweeney, James Mitchell, Shanon Bachman, Chou-Pong Pau, Walid Heneine, J Gerardo García-Lerma   +9 more
doaj   +1 more source

Linking the Population Pharmacokinetics of Tenofovir and Its Metabolites With Its Cellular Uptake and Metabolism

CPT: Pharmacometrics & Systems Pharmacology, 2014
Empirical pharmacokinetic models are used to explain the pharmacokinetics of the antiviral drug tenofovir (TFV) and its metabolite TFV diphosphate (TFV‐DP) in peripheral blood mononuclear cells.
K Madrasi, R N Burns, C W Hendrix, M J Fossler, A Chaturvedula   +4 more
doaj   +1 more source

Vaginal microbiota and mucosal pharmacokinetics of tenofovir in healthy women using tenofovir and tenofovir/levonorgestrel vaginal rings.

PLoS ONE, 2019
Recent data support that the vaginal microbiota may alter mucosal pharmacokinetics (PK) of topically delivered microbicides. Our team developed an intravaginal ring (IVR) that delivers tenofovir (TFV) (8-10 mg/day) alone or with levonorgestrel (LNG) (20 ...
Andrea Ries Thurman, Jill L Schwartz, Jacques Ravel, Pawel Gajer, Mark A Marzinke, Nazita Yousefieh, Sharon M Anderson, Gustavo F Doncel   +7 more
doaj   +1 more source

Ticari Bankaların Etkinliklerinin VZA ve Malmquist TFV Endeksi ile İncelenmesi

Atatürk Üniversitesi İktisadi ve İdari Bilimler Dergisi, 2020
The aim of this study is to analyze the efficiency and productivity of commercial banks operating in Turkey. For this purpose, the efficiency and productivity of 23 commercial banks operating in Turkey, whose continuous data of the years 2005-2018 were reached, have been analyzed through DEA and Malmquist Total Factor Productivity Analysis.
ŞAHİN, Faruk, ÖZDEMİR, Dilek
openaire   +4 more sources

Hepatitis B surface antigen reduction as a result of switching from long‐term entecavir administration to tenofovir

JGH Open, 2020
Background and Aim Loss of hepatitis B surface antigen (HBsAg) is an important goal in the treatment of chronic hepatitis B. We investigated whether switching from long‐term entecavir (ETV) administration to tenofovir (TFV) (tenofovir alafenamide [TAF ...
Nobuharu Tamaki, Masayuki Kurosaki, Sakura Kirino, Koji Yamashita, Leona Osawa, Shuhei Sekiguchi, Yuka Hayakawa, Wan Wang, Mao Okada, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Nobuyuki Enomoto, Namiki Izumi   +19 more
doaj   +1 more source

Perspectives on the utility and interest in a point-of-care urine tenofovir test for adherence to HIV pre-exposure prophylaxis and antiretroviral therapy: an exploratory qualitative assessment among U.S. clients and providers

AIDS Research and Therapy, 2020
Background Real-time, objective measures of adherence to antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP) are needed to better assess adherence levels and to expedite clinical response for those with suboptimal adherence.
Ashley R. Bardon, Jane M. Simoni, Leif M. Layman, Joanne D. Stekler, Paul K. Drain   +4 more
doaj   +1 more source

Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

CPT: Pharmacometrics & Systems Pharmacology, 2020
Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion ...
Stephanie N. Liu, Zeruesenay Desta, Brandon T. Gufford   +2 more
doaj   +1 more source

A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study). [PDF]

PLoS ONE, 2015
The CHARM-01 study characterized the safety, acceptability, pharmacokinetics (PK), and pharmacodynamics (PD) of three tenofovir (TFV) gels for rectal application.
Ian Mcgowan, Ross D Cranston, Kathryn Duffill, Aaron Siegel, Jarret C Engstrom, Alexyi Nikiforov, Cindy Jacobson, Khaja K Rehman, Julie Elliott, Elena Khanukhova, Kaleab Abebe, Christine Mauck, Hans M L Spiegel, Charlene S Dezzutti, Lisa C Rohan, Mark A Marzinke, Hiwot Hiruy, Craig W Hendrix, Nicola Richardson-Harman, Peter A Anton   +19 more
doaj   +1 more source

Infant lung function: criteria for selecting tidal flow–volume loops

ERJ Open Research, 2022
Background Tidal flow–volume (TFV) loops are commonly recorded in infants during sleep, due to the more regular breathing patterns compared to the awake state. Standardised deselection of loops outside pre-specified ranges are based on periods of regular
Karen Eline Stensby Bains, Hrefna Katrín Gudmundsdóttir, Martin Färdig, Erik Amnö, Christine M. Jonassen, Björn Nordlund, Eva Maria Rehbinder, Håvard O. Skjerven, Corina Silvia Rueegg, Riyas Vettukattil, Karin C. Lødrup Carlsen   +10 more
doaj   +1 more source

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source