Results 261 to 270 of about 138,672 (332)

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis. [PDF]

Nat Cancer
Wang Z, Elbanna Y, Godet I, Gan S, Peters L, Lampe G, Chen Y, Xavier J, Huse M, Massagué J.   +9 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Correction: LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation. [PDF]

Oncogenesis
Morén A, Bellomo C, Tsubakihara Y, Kardassis D, Mikulits W, Heldin CH, Moustakas A.   +6 more
europepmc   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Obesity- and tumor-derived signals drive cancer-associated state transitions in breast mesenchymal stromal/stem cells reprogrammed by IL1RA or JAK inhibition. [PDF]

Exp Hematol Oncol
Ritter A, Hoock SC, Kreis NN, Roth S, Torres Colin RC, Friemel A, Wildner JM, Scherr I, Louwen F, Solbach C, Yuan J.   +10 more
europepmc   +1 more source

Impaired TGFβ Signaling in Plaque-Associated Microglia

Oliver Krzyzan, Angela Kuhla, Björn Spittau, Natascha Vidovic   +3 more
openalex   +2 more sources

Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene‐1 knockout female mice

, 2020
Anne Gingery, Malayannan Subramaniam, Kevin S. Pitel, Xiaodong Li, Hua Zhu Ke, Russell T. Turner, Urszula T. Iwaniec, John R. Hawse   +7 more
openalex   +2 more sources

Immune non‐response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches

HIV Medicine, EarlyView.
Abstract Introduction A proportion of people living with HIV (PLWH) fail to restore their CD4 count or their CD4/CD8 ratio despite effective antiretroviral therapy (ART). PLWH with immune non‐response (INR) are at a higher risk of both AIDS and non‐AIDS events. The underlying mechanisms of INR remain unclear.
Charlotte Silvestre, Antoine Gross, Alain Makinson   +2 more
wiley   +1 more source

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease. [PDF]

J Pathol
Cooper G, Gumbs JA, Alkharabsheh S, Lee KJ, Carter A, Coleman H, O'Heneghan-Yates NS, Ijaz R, Beamish E, Menezes LA, Liloglou T, Clegg PD, Canty-Laird EG.   +12 more
europepmc   +1 more source