Results 251 to 260 of about 132,620 (281)

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease. [PDF]

J Pathol
Cooper G, Gumbs JA, Alkharabsheh S, Lee KJ, Carter A, Coleman H, O'Heneghan-Yates NS, Ijaz R, Beamish E, Menezes LA, Liloglou T, Clegg PD, Canty-Laird EG.   +12 more
europepmc   +1 more source

Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice

The Journal of Physiology, EarlyView.
Abstract figure legend Diet‐induced obesity induced fibro‐adipogenic remodelling of the muscle–tendon unit, characterized by increased fibrosis, reduced specific force, impaired relaxation kinetics, elevated hysteresis, and reduced aerobic capacity and glucose tolerance.
Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Ingrida Balnyte, Polzonetti Valeria, Tomas Venckunas, Cameron Hill, Danguole Satkunskiene, Hans Degens   +9 more
wiley   +1 more source

Regulatory T cells in axial spondyloarthritis. [PDF]

Commun Biol
Pacheco A, Tavasolian F, Lim M, Inman RD.   +3 more
europepmc   +1 more source

ATOX1 alleviates radiation‐induced cardiac injury by modulating AMPK/NRF2 to inhibit myocardial oxidative stress and mitochondrial dysfunction

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
This study found that ATOX1 can alleviate radiation‐induced oxidative stress and mitochondrial damage, maintain mitochondrial function, and reduce oxidative stress by activating the AMPK/NRF2 signaling pathway, ultimately exerting a cardioprotective effect.
Wen Deng, Li Su
wiley   +1 more source

The chaperone GRP94 interacts with the proprotein convertase furin and regulates TGF-beta maturation in human primary M2 macrophages. [PDF]

Cell Death Discov
Baverel V, Wang F, Garrido C, Kohli E.
europepmc   +1 more source

Exploring the Lung–Liver Axis in Pulmonary Arterial Hypertension

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Among PAH patients without liver disease, subclinical liver dysfunction quantified by MELD‐Na associates with higher pulmonary vascular resistance and inflammatory activation of the pulmonary endothelium, characterized by an IL‐6‐centered transcriptional network enriched for leukocyte chemotaxis.
Navneet Singh, Jordan Lawson, Ashok Ragavendran, Somanshu Banerjee, Andy Hon, Alejandro Vega, Jason Hong, Christopher J. Mullin, Mandy Pereira, Allyson Sherman‐Roe, Alexander T. Jorrin, Tiffaney Cayton, Gregory Fishbein, James R. Klinger, William M. Oldham, Rui‐Sheng Wang, Zhiyu Dai, Michael Fallon, Elizabeth O. Harrington, Olin D. Liang, Soban Umar, Corey E. Ventetuolo   +21 more
wiley   +1 more source

One-step knock-in CAR constructs in human NK cells enable scalable, TGFβ1-resistant immunotherapy for solid tumors. [PDF]

Theranostics
Yee SM, Jeong JH, Kim D, Kang SB, Yoon H, Cho H, Park D, Jun E, Jang M.   +8 more
europepmc   +1 more source

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source