Results 61 to 70 of about 418,971 (241)

Refrigerated amniotic membrane maintains its therapeutic qualities for 48 hours

Frontiers in Bioengineering and Biotechnology
During wound healing, the migration of keratinocytes is critical for wound closure. The application of amniotic membrane (AM) on wounds with challenging contexts (e.g., chronification and diabetic foot ulcer) has proven very successful.
J. Stelling-Férez, J. Stelling-Férez, J. M. Puente-Cuadrado, V. Álvarez-Yepes, M. Alcaraz, M. Alcaraz, E. Tristante, I. Hernández-Mármol, I. Mompeán-Egea, A. M. García-Hernández, A. M. García-Hernández, F. J. Nicolás   +11 more
doaj   +1 more source

Integration of TGF-β-induced Smad signaling in the insulin-induced transcriptional response in endothelial cells. [PDF]

, 2019
Insulin signaling governs many processes including glucose homeostasis and metabolism, and is therapeutically used to treat hyperglycemia in diabetes. We demonstrated that insulin-induced Akt activation enhances the sensitivity to TGF-β by directing an ...
Budi, Erine H, Derynck, Rik, Gao, Shaojian, Hoffman, Steven, Zhang, Ying E   +4 more
core  

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition [PDF]

, 2018
The best characterized signaling pathway downstream of transforming growth factor β (TGF-β) is through SMAD2 and SMAD3. However, TGF-β also induces phosphorylation of SMAD1 and SMAD5, but the mechanism of this phosphorylation and its functional relevance
Anido, BabuRajendran, Bellomo, Campbell, Chen, Coda, Cuny, DaCosta Byfield, Daly, Daly, Diepenbruck, Dobin, Dontu, Gaarenstroom, Germain, Goumans, Goumans, Grönroos, Grünert, Hatsell, Heinz, Hino, Hoodless, Horton, Huang, Inman, Itoh, Kang, Kowanetz, Kretzschmar, Lasorella, Lechleider, Levy, Li, Li, Liu, Liu, Love, Luo, Massagué, Massagué, Massagué, Meulmeester, Michel, Miettinen, Miller, Minn, Miyazono, Morikawa, Morikawa, Nam, Nicolás, Nicolás, Padua, Padua, Pardali, Peinado, Piek, Qin, R Development Core Team, Ran, Robinson, Ross, Sako, Shi, Stankic, Subramanian, Takahashi, Vizán, Wakefield, Wang, Wieser, Wrana, Wrighton, Wu, Wu, Ye, Zhang   +77 more
core   +5 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression

Cell Death and Disease
Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have delved into the role of iron and senescence in an experimental model of chronic liver ...
Josep Amengual, Ania Alay, Javier Vaquero, Ester Gonzalez-Sanchez, Esther Bertran, Aránzazu Sánchez, Blanca Herrera, Kathleen Meyer, Mate Maus, Manuel Serrano, María Luz Martínez-Chantar, Isabel Fabregat   +11 more
doaj   +1 more source

The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake [PDF]

, 2016
The anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation by suppressing the expression of key genes implicated in the uptake of modified lipoproteins.
Ashlin, Tim G., Davies, Thomas S., Foka, Pelagia, Gallagher, Hayley, Michael, Daryn R., Ramji, Dipak P., Salter, Rebecca C.   +6 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage [PDF]

, 2012
INTRODUCTION: Previous studies have indicated that transforming growth factor β (TGF-β) signaling has a critical role in cartilage homeostasis and repair, yet the mechanisms of TGF-β's chondroprotective effects are not known.
Alan Eberhardt, Girish Ramaswamy, Philip Sohn, Rosa Serra   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Distinct roles of amniotic membrane epithelial (hAEC) and mesenchymal stromal cells (hAMSC) in amniotic membrane-driven wound healing

Scientific Reports
Human skin wound healing is a complex process involving sequential cellular events to restore skin integrity. Chronic wounds fail to heal due to impaired keratinocyte activation and dysregulated cytokine signaling.
M. Alcaraz, I. Hernández-Mármol, J. M. Puente-Cuadrado, M. Rodríguez-Valiente, A. R. Silini, O. Parolini, F. J. Nicolás   +6 more
doaj   +1 more source