Results 1 to 10 of about 431,292 (339)
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes [PDF]
, 2013 CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced ...
A Diaz +52 more
core +10 more sources
Latent-TGF-β has a domain swapped architecture [PDF]
Nature CommunicationsThe multifunctional cytokine TGF-β is a dimeric protein produced within a latent complex (L-TGF-β). Latency is maintained by disulfide linked homodimeric prodomains forming a ring encircling the non-covalently bound mature TGF-β homodimer.
Mingliang Jin +6 more
doaj +2 more sources
Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17 [PDF]
, 2016 Transforming growth factor-beta (TGF-β) plays a dual role in hepatocytes, inducing both pro- and anti-apoptotic responses, whose balance decides cell fate.
Caja Puigsubirà, Laia +9 more
core +3 more sources
Frontiers in Bioengineering and Biotechnology, 2021 The application of amniotic membrane (AM) on chronic wounds has proven very effective at resetting wound healing, particularly in re-epithelialization. Historically, several aspects of AM effect on wound healing have been evaluated using cell models.
Catalina Ruiz-Cañada +5 more
doaj +1 more source
The TGF-β/NADPH Oxidases Axis in the Regulation of Liver Cell Biology in Health and Disease
Cells, 2021 The Transforming Growth Factor-beta (TGF-β) pathway plays essential roles in liver development and homeostasis and become a relevant factor involved in different liver pathologies, particularly fibrosis and cancer. The family of NADPH oxidases (NOXs) has
Macarena Herranz-Itúrbide +4 more
doaj +1 more source
Dissecting the role of the NADPH oxidase NOX4 in TGF-beta signaling in hepatocellular carcinoma
Redox Biology, 2023 The NADPH oxidase NOX4 has been proposed as necessary for the apoptosis induced by the Transforming Growth Factor-beta (TGF-β) in hepatocytes and hepatocellular carcinoma (HCC) cells.
Rut Espinosa-Sotelo +17 more
doaj +1 more source
Role of TGF-β in Skin Chronic Wounds: A Keratinocyte Perspective
Cells, 2020 Chronic wounds are characterized for their incapacity to heal within an expected time frame. Potential mechanisms driving this impairment are poorly understood and current hypotheses point to the development of an unbalanced milieu of growth factor and ...
Sergio Liarte +2 more
doaj +1 more source
Cells, 2020 Defects in wound closure can be related to the failure of keratinocytes to re-epithelize. Potential mechanisms driving this impairment comprise unbalanced cytokine signaling, including Transforming Growth Factor-β (TFG-β).
Sergio Liarte +2 more
doaj +1 more source
NADPH oxidase 4 (Nox4) deletion accelerates liver regeneration in mice
Redox Biology, 2021 Liver is a unique organ in displaying a reparative and regenerative response after acute/chronic damage or partial hepatectomy, when all the cell types must proliferate to re-establish the liver mass.
M. Herranz-Itúrbide +11 more
doaj +1 more source
Frontiers in Endocrinology, 2023 Skin wound healing is a physiological process that involves several cell types. Among them, endothelial cells are required for inflammation resolution and neo‐angiogenesis, both necessary for tissue restoration after injury.
Javier Stelling-Férez +6 more
doaj +1 more source