Results 111 to 120 of about 431,292 (339)

Hubungan Kadar Transforming Growth Factor-Beta 1 (TGF-β1) Urin dengan Proteinuria pada Anak Sindrom Nefrotik Resisten Steroid

Jurnal Kedokteran Brawijaya, 2013
 Transforming  Growth  Factor-Beta  1  (TGF-β1)  menjadi  perantara  fibrosis  interstisial,  atrofi  tubular,  dan  kerusakan gromelurus ginjal. Proteinuria menunjukkan prognosis yang buruk pada  sindroma nefrotik. Terdapat kecenderungan persisten proteinuria pada sindroma nefrotik resisten steroid.
Prasetya Ismail P, L Enggar Fitri, Krisni Subandijah   +2 more
openaire   +2 more sources

TGF-β/Smad signaling in renal fibrosis

Frontiers in Physiology, 2015
TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis. TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects. Among them, Smad signaling is recognized as a major pathway of TGF-β signaling in progressive renal fibrosis. During fibrogenesis, Smad3 is highly activated, which is
Meng, Xiao-Ming, Tang, Patrick Ming-Kuen, Li, Jun, Lan, Hui Yao   +3 more
openaire   +3 more sources

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

Overexpression of NNT‐AS1 Activates TGF‐β Signaling to Decrease Tumor CD4 Lymphocyte Infiltration in Hepatocellular Carcinoma [PDF]

, 2020
Yakun Wang, Lei Yang, Xichen Dong, Xin Yang, Xinxue Zhang, Zhe Liu, Xin Zhao, Tao Wen   +7 more
openalex   +1 more source

Additional file 8: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Table S3. SILAC of differential proteins in HepG2-RNF38 and HepG2-vector (Down-regulated) (DOCX 37 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Additional file 3: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Figure S1. Analysis RNF38 mRNA level in gastrointestinal tumor vs. normal tissues. A-D. RNF38 mRNA level was up-regulated in colon cancer, gastric cancer, and liver cancer, compared to normal tissues (All data retrieved from www.oncomine.org ). (PDF 114 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Profile of Transforming Growth Factor-β Responses During the Murine Hair Cycle [PDF]

, 1935
Transforming growth factor-β (TGF-β) appears to promote the regression phase of the mammalian hair cycle, in vivo in mice and in organ culture of human hair follicles.
DíAdamio, Dobens, Dobens, Dohrmann, Dohrmann, Faure, Foitzik, Foitzik, Hamil, Harlow, Hennings, Hino, Hino, Kawamata, Kester, Kester, Larisch, Lindner, Luetteke, Luetteke, Massague, Ohta, Ohta, Omotehara, Paus, Persson, Raftery, Seidel, Shibanuma, Soma, Soma, Uchida, Yamaguchi   +32 more
core   +1 more source

Additional file 1: of miR-190 suppresses breast cancer metastasis by regulation of TGF-β-induced epithelialâ mesenchymal transition

, 2018
Supplementary Materials and Methods. Figure S1. miR-190 does not affect cell proliferation in breast cancer. Figure S2. miR-190 promotes cell invasion but does not affect cell proliferation in MDA-MB-231-luc cells. Figure S3. miR-190 suppresses breast cancer metastasis and EMT phenotype in BT549 cells. Table S1. Primers used for RT-qPCR. (DOCX 2080 kb)
Yu, Yue, Luo, Wei, Yang, Zheng-Jun, Chi, Jiang-Rui, Li, Yun-Rui, Ding, Yu, Ge, Jie, Wang, Xin, Cao, Xu-Chen   +8 more
openaire   +1 more source