Results 121 to 130 of about 431,292 (339)

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Differential regulation of TGF-β-induced, ALK-5-mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastoma [PDF]

, 2017
Background The transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF) pathways have a major role in the pathogenesis of glioblastoma, notably immunosuppression, migration, and angiogenesis, but their interactions have remained ...
Seystahl, Katharina, Szabo, Emese, Tabatabai, Ghazaleh, Tritschler, Isabel, Weller, Michael   +4 more
core  

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 [PDF]

, 2018
Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic ...
A Dutta, A Prudova, B Croix St, C Zenzmaier, C Zenzmaier, CL Busceti, CP Goswami, CP Goswami, CY Fu, D Bello-DeOcampo, D Fong, D Romero, D Romero, D Romero, DA Barron, EJ Tokar, Emmanouil Stylianakis, F Abarzua, F Gao, G Ayala, G Untergasser, Giacomo Domenici, GN Thalmann, H Bauderlique-Le Roy, H Kumon, H Kumon, H Ross-Adams, Hoda Kardooni, Ignacio Zabalza, Irantzu Gorroño-Etxebarria, J Debnath, J Veeck, Jennifer H. Steel, JL Leonard, JN Shah, Jonathan Waxman, JP Webber, L Buscemi, LR Rohrschneider, M Augsten, M Bekhouche, M Hangai, M Piva, M Zhu, Maria dM Vivanco, Miriam Rabano, MM Webber, MP Ween, N Fujimoto, N Yu, P Smits, P Su, Robert M. Kypta, S Dennler, T Li, TD Schmittgen, VE Krupnik, Virginia Murillo-Garzón, VP Montecinos, WY Chen, X Wang, Y Gong, Y Kawano, Y Niu, Z Tu, Zainab Al Shareef   +65 more
core   +2 more sources

Additional file 1: of Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

, 2019
Supplementary methods and materials and figure legends. (DOCX 19 kb)
Peng, Rui, Zhang, Peng-Fei, Yang, Xuan, Wei, Chuan-Yuan, Huang, Xiao-Yong, Cai, Jia-Bin, Lu, Jia-Cheng, Gao, Chao, Sun, Hai-Xiang, Gao, Qiang, Bai, Dou-Sheng, Shi, Guo-Ming, Ke, Ai-Wu, Fan, Jia   +13 more
openaire   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

BMC Cell Biology, 2006
Background In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour.
Heldin Carl-Henrik, Itoh Susumu, Itoh Fumiko, Goumans Marie-José, Valdimarsdottir Gudrun, Dijke Peter   +5 more
doaj   +1 more source

Gremlin activates the smad pathway linked to epithelial mesenchymal transdifferentiation in cultured tubular epithelial cells [PDF]

, 2014
Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-(TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis.
Carvajal, Gisselle, Droguett, Alejandra, Egido de los Ríos, Jesús, García-Redondo, Ana Belén, Lavoz, Carolina, Mezzano, Sergio, Ortiz Arduán, Alberto, Rodrigues Díez, Raquel, Rodrigues Díez, Raúl, Rodríguez, Isabel, Ruíz-Ortega, Marta   +10 more
core   +4 more sources

MOESM1 of CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

, 2018
Additional file 1: Table S1. Relationships between FoxP3+ and CD8+ infiltrating T cells and clinicopathological characteristics.
Pu, Ning, Guochao Zhao, Hanlin Yin, Jian-Ang Li, Abulimiti Nuerxiati, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Dayong Jin, Wenhui Lou, Wenchuan Wu   +10 more
openaire   +1 more source

Germanane Quantum Dots Promote Metabolic Reprogramming of Immune Cells Toward Regulatory T Cells and Suppress Inflammation In Vitro and In Vivo

Advanced Functional Materials, EarlyView.
Metabolic changes in immune cells direct the phenotype and function of the host immune system. Smart nanomaterials must target metabolic pathways to direct immune cell fate. This study reports the fabrication and first application of germanane quantum dots (GeHQDs) to modulate inflammation in vitro and in vivo.
Abhay Srivastava, Alireza Rafieerad, Weiang Yan, Keshav Narayan Alagarsamy, Qingdong Guan, Leena Regi Saleth, Michel Aliani, Sanjiv Dhingra   +7 more
wiley   +1 more source

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells [PDF]

, 2017
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activation of host immunosuppressive regulatory T (Treg) cells.
Anderton, SM, Brenn, T, Chambers, RC, Filbey, KJ, Harcus, Y, Hewitson, JP, Hinck, AP, Hinck, CS, Ivens, A, Johnston, CJC, Kemter, AM, Kildemoes, AO, Kodali, RB, Le Bihan, T, Maizels, RM, McSorley, HJ, Smyth, DJ, Soares, DC, White, MPJ, Wigmore, SJ, Woodcock, HV   +20 more
core