Results 271 to 280 of about 431,292 (339)

HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro

, 2018
Li Liu, Huan Liu, Yangying Zhou, Jiaofeng He, Qiong Liu, Jian Wang, Manting Zeng, Dan Yuan, Fengbo Tan, Yuan Zhou, Haiping Pei, Hong Zhu   +11 more
openalex   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Loss of ALK4 promotes cancer progression through regulating TGF-β receptor N-glycosylation. [PDF]

Nat Commun
Zhang M, Chen J, Leupold MC, Guo J, Shen X, Shirley CA, Khella CA, Mehta RN, O'Brien ET, Gatza ML, Blobe GC.   +10 more
europepmc   +1 more source

YAP and TAZ are Mechanoregulators of TGF-β-Smad Signalling and Fibrogenesis

, 2015
Stephen G. Szeto
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Disrupting BMP/TGF-β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells. [PDF]

Compr Physiol
Keskinidou C, Lotsios NS, Papavassiliou KA, Papavassiliou AG, Dimopoulou I, Kotanidou A, Langleben D, Orfanos SE, Vassiliou AG.   +8 more
europepmc   +1 more source

Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling

, 2015
Dongyang Xu, Duo Li, Zhi-Yong Lü, Xingli Dong, Xiaofeng Wang   +4 more
openalex   +2 more sources

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Spatial transcriptomics reveals TGF-β-driven endothelial-mesenchymal transition in vascular remodeling of moyamoya disease. [PDF]

J Cereb Blood Flow Metab
Xiao J, Wei L, Chen D, Qiu X, Yan J, Li Y, Lin F, Wu X, Xiang X, Huang Y, Yu C, Wang X, Zhang S, Luo D, Zeng E.   +14 more
europepmc   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source