Results 261 to 270 of about 318,750 (310)
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Zeitschrift fur Rheumatologie, 2012
T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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T helper cells contribute to the induction and maintenance of rheumatic inflammation through the secretion of cytokines. The analysis of Th1 cells expressing interferon-γ, Th17 cells expressing interleukin-17 and the newly described Th1+17 cells could give insight into the pathophysiological mechanisms of rheumatic diseases.
H-D, Chang, T, Kamradt, H, Schulze-Koops
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International Archives of Allergy and Immunology, 2000
Over the last few years, it has been recognized that along with structural components and products of bacteria, bacterial DNA is also capable of signaling infectious danger to cells of the innate immune system. Particular DNA sequences (CpG motifs), which are abundant in prokaryotic (bacterial) but not in mammalian DNA, cause the activation and ...
K, Heeg, S, Zimmermann
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Over the last few years, it has been recognized that along with structural components and products of bacteria, bacterial DNA is also capable of signaling infectious danger to cells of the innate immune system. Particular DNA sequences (CpG motifs), which are abundant in prokaryotic (bacterial) but not in mammalian DNA, cause the activation and ...
K, Heeg, S, Zimmermann
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Springer Seminars in Immunopathology, 1999
Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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Cytokines produced by T helper (Th) cells are of critical importance for the outcome of many infectious diseases. Producing the "right" set of cytokines in response to an infectious agent can be a matter of life or death. The Th1/Th2 dichotomy, although an oversimplification has proven useful in the analysis of immune responses to infections.
C, Infante-Duarte, T, Kamradt
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Journal of Theoretical Biology, 1994
We present and analyze a model for the cross-regulation of the Th1 and Th2 helper cell subsets during an immune response by the regulatory cytokines interferon-gamma (IFN)-gamma) and interleukin-10 (IL-10). IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of Th2 cells.
M A, Fishman, A S, Perelson
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We present and analyze a model for the cross-regulation of the Th1 and Th2 helper cell subsets during an immune response by the regulatory cytokines interferon-gamma (IFN)-gamma) and interleukin-10 (IL-10). IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of Th2 cells.
M A, Fishman, A S, Perelson
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The immunogenic peptide for Th1 development
International Immunopharmacology, 2003Th1 cells play a critical role in the induction of cell-mediated immune responses and eradication of intracellular pathogen. The dose and route of immunization of antigen are also determining factors. It remains unclear what types of immunogenic peptide can induce the Th1 development and how it acts to regulate the immune system.
Kiyoshi, Takatsu, Ai, Kariyone
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Th1/Th2 balance in preeclampsia
Journal of Reproductive Immunology, 2003The syndrome of preeclampsia has previously been ascribed to generalized maternal endothelial dysfunction, poor placentation and excessive maternal inflammatory response. Recent reports suggest that preeclampsia is associated with a Th1 predominant profile and may be considered as a failure of the tolerance system allowing the second physiological ...
Shigeru, Saito, Masatoshi, Sakai
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CCR5 is characteristic of Th1 lymphocytes
Nature, 1998CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites.
P, Loetscher +6 more
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MIG Th1 chemokine in Vitiligo.
La Clinica terapeutica, 2018The importance of the Type-1 helper immune response in the development of Vitiligo (Vit), and of chemokine receptor (CXCR)3 receptor and its chemokine monokine induced by interferon (IFN)-γ(MIG) has been shown by several studies. MIG/ interferon (IFN)-γ-inducible protein 10 (IP10) /CXCR3 axis mediated T-cell recruitment into the skin in Vit is an early
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The Th1/Th2 balance in autoimmunity
Current Opinion in Immunology, 1995The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2 (Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type to the development of a particular autoimmune response can influence whether or not this response leads to clinical disease.
B, Charlton, K J, Lafferty
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TH1-TH2: a Procrustean paradigm
Nature Immunology, 2003Although immunologists have found the dichotomous helper T cell subset model a useful construct, it is beginning to show its age. Some suggest that proponents of the TH1-TH2 dichotomy are overzealous in making the data conform to the scheme, like Procrustes who stretched or truncated his guests so that they would fit his guest bed.
Dennis O, Gor +2 more
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