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Clinical Immunology and Immunopathology, 1996
A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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An Update on Human Th1 and Th2 Cells
International Archives of Allergy and Immunology, 2009The existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic cell subset has been established. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and preferential expression of some ...
ROMAGNANI, SERGIO +11 more
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Sarcoidosis and the Th1 chemokine MIG.
La Clinica terapeutica, 2018Sarcoidosis is a systemic inflammatory disease, affecting any organ, and that can be discovered by accident in approximately 5% of cases. High levels of the type-1 helper (Th1)-dependent chemokine, monokine induced by interferon (IFN)-γ (MIG)/chemokine (C-X-C motif) ligand (CXCL)9, and its receptor CXCR3 have been reported in bronchoalveolar lavage and
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2013
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Th1 chemokines in ulcerative colitis.
La Clinica terapeutica, 2015Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 (a chemokine receptor in the CXC family) and its ligand chemokines, monokine induced by interferon (IFN)-γ(MIG), IFN-γ-inducible protein 10 (IP-10) and IFN-inducible T-cell α chemoattractant (I-TAC), are strongly overexpressed in the intestinal mucosa of mice with experimental ...
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The TH1/TH2 paradigm in allergy
Immunotechnology, 1998Recent evidence has been accumulated to suggest that allergen-reactive type 2 helper T cells (Th2) play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, i.e. the cellular triad involved in the allergic inflammation.
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Two Sequential Activation Modules Control the Differentiation of Protective T Helper-1 (Th1) Cells
Immunity, 2021Dmitri I Kotov +2 more
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Induction of a Colitogenic Phenotype in Th1-Like Cells Depends on Interleukin-23 Receptor Signaling
Immunity, 2022Brianna M L Regan
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Prognostic Value of Th1/Th2 Ratio in Rheumatoid Arthritis
Lancet, The, 1998Ben A C Dijkmans, R A van Lier
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