Results 271 to 280 of about 230,695 (309)
Some of the next articles are maybe not open access.
Zeitschrift für Rheumatologie, 2011
T-Helfer-Zellen tragen mit der Sekretion von Zytokinen zur Induktion und Aufrechterhaltung rheumatischer Entzundungen bei. Die Untersuchung von Interferon-γ-produzierenden Th1-Zellen, Interleukin-17-produzierenden Th17-Zellen und die vor Kurzem beschriebenen Th1+17-Zellen konnten Einblicke in pathophysiologische Mechanismen rheumatischer Entzundungen ...
Thomas Kamradt +3 more
openaire +2 more sources
T-Helfer-Zellen tragen mit der Sekretion von Zytokinen zur Induktion und Aufrechterhaltung rheumatischer Entzundungen bei. Die Untersuchung von Interferon-γ-produzierenden Th1-Zellen, Interleukin-17-produzierenden Th17-Zellen und die vor Kurzem beschriebenen Th1+17-Zellen konnten Einblicke in pathophysiologische Mechanismen rheumatischer Entzundungen ...
Thomas Kamradt +3 more
openaire +2 more sources
Current Opinion in Hematology, 2001
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
Richard A. Flavell, Chen Dong
openaire +3 more sources
After activation, CD4 helper T (Th) cells differentiate into Th1or Th2 effector subsets. These two types of cells produce distinct profiles of cytokines and regulate different immune responses. This review summarizes recent progress on different features of co-stimulatory regulation and chemokine-mediated homing of Th1 and Th2 cells.
Richard A. Flavell, Chen Dong
openaire +3 more sources
TH1-TH2: a Procrustean paradigm [PDF]
Nature Immunology, 2003 Although immunologists have found the dichotomous helper T cell subset model a useful construct, it is beginning to show its age. Some suggest that proponents of the TH1-TH2 dichotomy are overzealous in making the data conform to the scheme, like Procrustes who stretched or truncated his guests so that they would fit his guest bed.
Noel R. Rose +2 more
openaire +2 more sources
Revisiting the Th1/Th2 Paradigm
Scandinavian Journal of Immunology, 1998The identification of subsets of CD4+ helper cells producing distinct pattern of cytokines has provided a valuable framework for understanding how different effector populations of immune cells can be recruited in vivo during infection. In the view of most investigators, Th1 and Th2 cells produce factors that serve as their own autocrine factors and ...
Muraille, Eric, Leo, Oberdan
openaire +3 more sources
CCR5 is characteristic of Th1 lymphocytes
Nature, 1998CD4+ lymphocytes can be assigned to two subsets1. Th1 lymphocytes secrete interferon gamma (IFNγ) and lymphotoxin, promoting cell-mediated immunity to intracellular pathogens; and Th2 lymphocytes secrete interleukins 4 and 5 (IL-4 and IL-5), which function in allergy and humoral immunity to parasites.
Marco Baggiolini +6 more
openaire +2 more sources
Immunology Today, 1997
Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
openaire +4 more sources
Abstract The Th1/Th2 paradigm provides a useful model for understanding the pathogenesis of several diseases, as well as for developing novel immunotherapeutic strategies. Here, Sergio Romagnani examines Th1/Th2 polarization in the context of associated pathophysiological conditions.
openaire +4 more sources
The immunogenic peptide for Th1 development
International Immunopharmacology, 2003Th1 cells play a critical role in the induction of cell-mediated immune responses and eradication of intracellular pathogen. The dose and route of immunization of antigen are also determining factors. It remains unclear what types of immunogenic peptide can induce the Th1 development and how it acts to regulate the immune system.
Kiyoshi Takatsu, Ai Kariyone
openaire +2 more sources
Inflammatory Bowel Diseases, 1999
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
openaire +3 more sources
A large body of evidence indicates the existence of functionally polarized CD4+ T-cell responses based on their profile of cytokine secretion. Type 1 T helper (Th1) cells produce interferon-gamma, interleukin (IL)-2, and tumour necrosis factor (TNF)-beta, which activate macrophages and are responsible for cell-mediated immunity and phagocyte-dependent ...
openaire +3 more sources