Results 291 to 300 of about 230,695 (309)
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1999
The immune system has evolved different defensive mechanisms against pathogens. The first defensive line is provided by “natural” immunity, including phagocytes, T cell receptor (TCR) γδ+ T cells, natural killer (NK) cells, mast cells, neutrophils and eosinophils, as well as complement components and proinflammatory cytokines, such as interferons (IFNs)
D'ELIOS, MARIO MILCO, G. Del Prete
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The immune system has evolved different defensive mechanisms against pathogens. The first defensive line is provided by “natural” immunity, including phagocytes, T cell receptor (TCR) γδ+ T cells, natural killer (NK) cells, mast cells, neutrophils and eosinophils, as well as complement components and proinflammatory cytokines, such as interferons (IFNs)
D'ELIOS, MARIO MILCO, G. Del Prete
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Th1 chemokines in ulcerative colitis.
La Clinica terapeutica, 2015Many studies have shown that chemokine (C-X-C motif) receptor (CXCR)3 (a chemokine receptor in the CXC family) and its ligand chemokines, monokine induced by interferon (IFN)-γ(MIG), IFN-γ-inducible protein 10 (IP-10) and IFN-inducible T-cell α chemoattractant (I-TAC), are strongly overexpressed in the intestinal mucosa of mice with experimental ...
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Genetic Polymorphism and Th1/Th2 Orientation
International Archives of Allergy and Immunology, 2005<i>Background:</i> It is likely that besides developmental and environmental factors, genetic factors also play an important role in Th1/Th2 orientation and susceptibility to related disorders. Thus, for each genetic factor involved one would expect an opposite pattern of susceptibility towards Th1- and Th2-associated diseases.
BOTTINI, NUNZIO +4 more
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Clinical Immunology and Immunopathology, 1996
A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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A large body of evidence suggests the existence of functionally polarized human T cell responses based on their profile of cytokine secretion in both the CD4+ T helper (Th) and the CD8+ T cytotoxic (Tc) cell subset. Human Th1 and Th2 cells not only produce a different set of cytokines but also exhibit distinct functional properties and the preferential
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Th1/Th2 lymphocyte polarization in asthma
Allergy, 2000Asthma is a complex inflammatory disease of the lung characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inflammation in asthma consists of airway infiltration by mast cells, lymphocytes, and eosinophils.
MAZZARELLA, Gennaro +4 more
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Sarcoidosis and the Th1 chemokine MIG.
La Clinica terapeutica, 2018Sarcoidosis is a systemic inflammatory disease, affecting any organ, and that can be discovered by accident in approximately 5% of cases. High levels of the type-1 helper (Th1)-dependent chemokine, monokine induced by interferon (IFN)-γ (MIG)/chemokine (C-X-C motif) ligand (CXCL)9, and its receptor CXCR3 have been reported in bronchoalveolar lavage and
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Th1 and Th2 Cytokines in Leishmaniasis
2003The intracellular protozoan Leishmania are obligate parasites of macrophages that can infect various mammalian hosts such as rodents, dogs, and humans (1). At least 20 Leishmania species can trigger pathogenic processes in humans. The host-to-host transmission of the parasite occurs through the bite of its hematophagous vector, the female sandfly ...
Geneviève Milon +2 more
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Bladder cancer and Th1 chemokines
La Clinica terapeutica, 2017Bladder cancer arises from the epithelial lining of the urinary bladder, and it is known as transitional cell carcinoma (TCC). Tobacco smoking is the main known contributor to urinary bladder cancer. However thirty percent of bladder tumors probably result from occupational exposure in the workplace to carcinogens.
Poupak Fallahi, S.R. Paparo
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TH1 and TH2 Response in Eczema
1997Within the helper T cell population, heterogeneity exists regarding the cytokines secreted and the functions carried out. T helper (TH) 1 cells secrete interferon (IFN)-γ and interleukin (IL)-2 but not IL-4, whereas TH2 cells secrete IL-4 and -5 but not IFN-γ.
O. Kilgus +5 more
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Allergy, 2004
The main reason for the asthma epidemic in industrialized countries is unknown. While childhood mortality from acute respiratory infection is still high in developing countries where asthma prevalence is low, there might be a suppressed natural selection in industrialized countries with a high asthma prevalence.
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The main reason for the asthma epidemic in industrialized countries is unknown. While childhood mortality from acute respiratory infection is still high in developing countries where asthma prevalence is low, there might be a suppressed natural selection in industrialized countries with a high asthma prevalence.
openaire +3 more sources