Results 231 to 240 of about 260,137 (386)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development. [PDF]

J Clin Invest
Wu H, Zhong X, Ma N, He Z, Wang G, Lu G, Yuan YC, Zhang W, Shi Y, Vaidehi N, Peelen E, Wulff T, Gege C, Kohlhof H, Vitt D, Gwack Y, Taniuchi I, Xue HH, Sun Z.   +18 more
europepmc   +1 more source

Th17 Differentiation in Hyper IgE Syndrome; IL-17 Secretion and RORγt Expression

, 2013
Tunç Akkoç, İsmail Öğülür, Ayzer Tevetoğlu, Ayşegül İZGİ, Özden Hatırnaz-Ng, Yuk YinNg, Safa Barış, Elif KarakocAydiner   +7 more
openalex   +2 more sources

Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity [PDF]

, 2016
Min Jung Lee, Eri Yoshimoto, Shinobu Saijo, Yoichiro Iwakura, Xin Lin, Howard R. Katz, Yoshihide Kanaoka, Nora A. Barrett   +7 more
openalex   +1 more source

RORγt‐APCs: The New Masters of Oral Tolerance

Barrier Immunity, EarlyView.
ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley   +1 more source

Soluble CD14 promotes Th17 expansion and differentiation through gamma-aminobutyric acid and expands infidel innate lymphoid cells. [PDF]

PNAS Nexus
Shahbaz S, Rahmati A, Syed H, Elahi S.
europepmc   +1 more source

EXPRESSION OF TH17-LYMPHOCYTE ADAPTER – TRAF3IP2 IN THE SKIN OF PSORIASIS PATIENTS

, 2014
В. Р. Хайрутдинов, Anastasiya F. Mikhailichenko, A. A. Piskunova, Н. В. Бычкова, А. В. Самцов, Evgeny N. Imyanitov   +5 more
openalex   +2 more sources

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Nature, 2007
T. Korn, E. Bettelli, Wenda Gao, A. Awasthi, A. Jäger, T. Strom, M. Oukka, V. Kuchroo   +7 more
semanticscholar   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Role of CD5 signalling for pro-inflammatory Th17 response in multiple sclerosis. [PDF]

Brain
Pape K, Hanuscheck N, Schmaul S, Kneilmann F, Bündgen G, Wasser B, Steffen F, Engel S, Luessi F, Klein M, Bohn T, Bopp T, Bittner S, Zipp F.   +13 more
europepmc   +1 more source