Results 321 to 330 of about 187,124 (359)

Pharmacological Modulation of Th17

Recent Patents on Inflammation & Allergy Drug Discovery, 2009
Recently, a third subset of Th17 cells has been described. This T helper subset induces the release of chemokines and growth factors and causes neutrophil accumulation in several mammalian organs. Pharmacological intervention blocking Th17 generation as well as IL-17 signaling might prove useful in a variety of diseases including asthma, chronic ...
Juan B, De Sanctis, Jenny V, Garmendia, Dolores, Moreno, Nancy, Larocca, Michael, Mijares, Camilo, Di Giulio, Margarita, Salazar-Bookaman, Gabriella, Wojewodka, Danuta, Radzioch   +8 more
openaire   +2 more sources

Th17 cells in inflammation

International Immunopharmacology, 2011
Naïve T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various ...
Akihiro, Kimura, Tadamitsu, Kishimoto
openaire   +2 more sources

Changes of Th17/Tc17 and Th17/Treg cells in endometrial carcinoma

Gynecologic Oncology, 2014
T helper 17 (Th17), T cytotoxic 17 (Tc17) and regulatory T (Treg) cells are important factors in the pathogenesis of inflammatory and autoimmune diseases. However, information concerning the roles of these cells in antitumor immunity or endometrial tumorigenesis remains limited.
Wenjing, Zhang, Fei, Hou, Yan, Zhang, Yongju, Tian, Jun, Jiao, Daoxin, Ma, Beihua, Kong, Baoxia, Cui   +7 more
openaire   +2 more sources

Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts

Gastroenterology, 2022
BACKGROUND & AIMS: Intestinal fibrosis is a significant complication of Crohn’s disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not completely understood.
Xiaojing Zhao, Wenjing Yang, Tianming Yu, Yu Yu, X. Cui, Zheng Zhou, H. Yang, Yanbo Yu, A. Bilotta, Suxia Yao, Jimin Xu, Jia Zhou, G. Yochum, W. Koltun, Austin Portolese, D. Zeng, Jingwu Xie, I. Pinchuk, Hongjie Zhang, Y. Cong   +19 more
semanticscholar   +1 more source

The Role of TH17 Cells in Multiple Sclerosis: Therapeutic Implications.

Autoimmunity Reviews, 2020
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T helper (TH) cells. The TH cells most commonly implicated in the pathogenesis of
T. Moser, K. Akgün, Undine Proschmann, J. Sellner, T. Ziemssen   +4 more
semanticscholar   +1 more source

Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity

Cancer Immunology, Immunotherapy, 2011
CD4(+) Th17 cells induce antitumor immunity leading to the eradication of established tumors. However, the mechanism of antitumour immunity and CTL activation by Th17 cells and the distinct role of Th17 and Th17-activated CTLs in antitumor immunity are still elusive.
Manjunatha, Ankathatti Munegowda, Yulin, Deng, Sean J, Mulligan, Jim, Xiang   +3 more
openaire   +2 more sources

Targeting the Th17 pathway in psoriasis

Journal of Leukocyte Biology, 2012
Abstract Review of preclinical and clinical evidence implicating Th17 cells in psoriasis, and the therapeutic approaches to target this pathway. In recent years, the classic paradigm of Th1/Th2 CD4+ T cell-mediated immunity has evolved to include the IL-17A-producing Th17 subset, a distinct proinflammatory CD4+ T cell ...
M Merle, Elloso, Mireia, Gomez-Angelats, Anne M, Fourie   +2 more
openaire   +2 more sources

Th17 Cells in Airway Diseases

Current Molecular Medicine, 2008
Chronic inflammation is a key feature of many airway diseases. Leukocyte accumulation in the lung has the capacity to mediate many aspects of the pathophysiology of such diseases including asthma and chronic obstructive pulmonary disease (COPD). Until recently, the CD4+ lymphocyte component of these inflammatory influxes was thought to consist of Th1 ...
Suzanne L, Traves, Louise E, Donnelly
openaire   +2 more sources

Th17 and Treg cells function in SARS‐CoV2 patients compared with healthy controls

Journal of Cellular Physiology, 2020
In the course of the coronavirus disease 2019 (COVID‐19), raising and reducing the function of Th17 and Treg cells, respectively, elicit hyperinflammation and disease progression.
A. Sadeghi, S. Tahmasebi, A. Mahmood, M. Kuznetsova, Hamed Valizadeh, A. Taghizadieh, Masoud Nazemiyeh, L. Aghebati-Maleki, F. Jadidi‐Niaragh, Sanaz Abbaspour-Aghdam, L. Roshangar, H. Mikaeili, M. Ahmadi   +12 more
semanticscholar   +1 more source

Th17 cells in inflammation and autoimmunity

Autoimmunity Reviews, 2014
T helper 17 (Th17), a distinct subset of CD4(+) T cells with IL-17 as their major cytokine, orchestrate the pathogenesis of inflammatory and autoimmune diseases. Dysregulated Th17 cells contribute to inflammatory and autoimmune diseases. Candidate biologics are in development for targeting IL-17, IL-17 receptors or IL-17 pathways.
Ram Pyare, Singh, Sascha, Hasan, Sherven, Sharma, Saranpreet, Nagra, Dean T, Yamaguchi, David T W, Wong, Bevra H, Hahn, Awlad, Hossain   +7 more
openaire   +2 more sources