RORγt and RORα signature genes in human Th17 cells
PLoS ONE, 2017 RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation.
Glenda Castro +15 more
semanticscholar +1 more source
CD73+ Dendritic Cells in Cascading Th17 Responses of Experimental Autoimmune Uveitis-Induced Mice
Frontiers in Immunology, 2020 Previous studies have shown that CD73 is pivotal in the conversion of pro-inflammatory adenosine triphosphate into anti-inflammatory adenosine and that immune cells of the same type that express different levels of CD73 are functionally distinct. In this
MinHee K. Ko +3 more
doaj +1 more source
Pattern recognition receptors in antifungal immunity [PDF]
, 2014 We thank the Wellcome Trust for funding this study.Peer reviewedPublisher ...
Brown, Gordon D +2 more
core +2 more sources
Trans-presentation of interleukin-6 by dendritic cells is required for priming pathogenic TH17 cells
Nature Immunology, 2016 The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that ...
Sylvia Heink +22 more
semanticscholar +1 more source
Impact of the gut microbiota-Th17 cell axis on inflammatory depression
Frontiers in PsychiatryDepression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression,
Xiuzhi Jia +9 more
doaj +1 more source
Regulative Differentiation as Bifurcation of Interacting Cell Population [PDF]
arXiv, 2007 In multicellular organisms, several cell states coexist. For determining each cell type, cell-cell interactions are often essential, in addition to intracellular gene expression dynamics. Based on dynamical systems theory, we propose a mechanism for cell differentiation with regulation of populations of each cell type by taking simple cell models with ...
arxiv
TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]
, 2013 Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William +5 more
core +1 more source
International Journal of Molecular Sciences, 2017 Wound healing is a crucial process which protects our body against permanent damage and invasive infectious agents. Upon tissue damage, inflammation is an early event which is orchestrated by a multitude of innate and adaptive immune cell subsets ...
L. Brockmann +3 more
semanticscholar +1 more source
Modelling cell-cell collision and adhesion with the Filament Based Lamellipodium Model [PDF]
arXiv, 2018 We extend the live-cell motility Filament Based Lamellipodium Model to incorporate the forces exerted on the lamellipodium of the cells due to cell-cell collision and cadherin induced cell-cell adhesion. We take into account the nature of these forces via physical and biological constraints and modelling assumptions. We investigate the effect these new
arxiv
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
core +1 more source