Results 111 to 120 of about 10,836,682 (383)
TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica. [PDF]
, 2013 Our gastrointestinal tract is a portal of entry for a number of bacteria and viruses. Thus, this tissue must develop ways to induce antigen-specific T cell and antibody responses quickly.
DePaolo, R William +5 more
core +1 more source
Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function
Cell Reports, 2016 Interleukin-23 (IL-23) is required for inflammatory Th17 cell function in experimental autoimmune encephalomyelitis (EAE), and IL-23 blockade reduces the number of effector Th17 cells in the CNS.
Fang Du +9 more
doaj +1 more source
Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome. [PDF]
PLoS ONE, 2013 BACKGROUND: Atherosclerosis is a chronic inflammatory disease mediated by immune cells. Th22 cells are CD4(+) T cells that secret IL-22 but not IL-17 or IFN-γ and are implicated in the pathogenesis of inflammatory disease.
Lei Zhang +11 more
doaj +1 more source
Advanced Materials, EarlyView.We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam +5 more
wiley +1 more source
The Journal of Clinical InvestigationFemale individuals have an increased prevalence of many Th17 cell–mediated diseases, including asthma. Androgen signaling decreases Th17 cell–mediated airway inflammation, and Th17 cells rely on glutaminolysis.
Nowrin U. Chowdhury +23 more
doaj +1 more source
Arthritis Research & Therapy, 2019 Background Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown.
Charlotte Klasen +5 more
doaj +1 more source
CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells
iScience, 2020 Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey +3 more
doaj +1 more source
Cell Death and Disease, 2023 Background Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential components in adaptive immune response in liver IRI, and forkhead box O1 ...
Haozhen Ren +10 more
doaj +1 more source
Inflammatory Bowel Diseases, 2019 BACKGROUND How the gut microbiota regulates intestinal homeostasis is not completely clear. Gut microbiota metabolite short-chain fatty acids (SCFAs) have been reported to regulate T-cell differentiation.
Liang Chen +10 more
semanticscholar +1 more source
Sox5 and Th17 cell differentiation
Oncotarget, 2015 Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1–2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and
Akira, Suto +2 more
openaire +2 more sources