Results 141 to 150 of about 10,836,682 (383)

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis [PDF]

, 2010
© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
AF Mourao, AK Andersson, Ana F Mourão, Ana M Rodrigues, BW Kirkham, C Gabay, DY Chen, Elsa Vieira-Sousa, ER Vossenaar, FA Houssiau, FC Arnett, G Parsonage, H Kokkonen, Helena Canhão, Henrique S Rosário, HJ Kim, IC Chikanza, Inês Perpétuo, J Cedergren, J Duarte, J Pene, JE Fonseca, JE Fonseca, JF Fries, Joaquim Polido-Pereira, João E Fonseca, K Nagatani, L Petrovic-Rackov, LA Joosten, LK Assi, LK Stamp, Luis Graca, M al-Janadi, M Chabaud, M Pelletier, Maria M Souto-Carneiro, ML Prevoo, Mário V Queiroz, P Barrera, P Weinmann, P Youinou, PE Poubelle, R Cascao, R Cascao, R Segal, RA Moura, Rita A Moura, Rita Cascão, S Kotake, SC Liang, TJ Smeets   +50 more
core   +3 more sources

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

S1PR1 mediates Th17 cell migration from the thymus to the skin in health and disease

Frontiers in Immunology
Th17 cells play crucial roles in host defense and the pathogenesis of autoimmune diseases in the skin. While their differentiation mechanisms have been extensively studied, the origin of skin Th17 cells remains unclear.
Jonas Engesser, Jonas Engesser, Huiying Wang, Huiying Wang, Sonja Kapffer, Anna Kaffke, Anna Kaffke, Anett Peters, Anett Peters, Hans-Joachim Paust, Hans-Joachim Paust, Markus Geissen, Christian F. Krebs, Christian F. Krebs, Ulf Panzer, Ulf Panzer, Nariaki Asada, Nariaki Asada   +17 more
doaj   +1 more source

Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis

International Journal of Molecular Sciences, 2017
Wound healing is a crucial process which protects our body against permanent damage and invasive infectious agents. Upon tissue damage, inflammation is an early event which is orchestrated by a multitude of innate and adaptive immune cell subsets ...
L. Brockmann, Anastasios D. Giannou, N. Gagliani, S. Huber   +3 more
semanticscholar   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease [PDF]

, 2008
© 2008 Zhu et al. This article is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).Maintaining tolerance of T cells to self-antigens
Kioussis, Dimitris, Li, Suling, Martin, Joanne E., Symonds, Alistair L.J., Wang, Ping, Wraith, David C., Zhu, Bo   +6 more
core   +3 more sources

Impact of the gut microbiota-Th17 cell axis on inflammatory depression

Frontiers in Psychiatry
Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression,
Xiuzhi Jia, Xiuzhi Jia, Jiayi Wang, Dan Ren, Kaibo Zhang, Hongliang Zhang, Tengchuan Jin, Tengchuan Jin, Songquan Wu, Songquan Wu   +9 more
doaj   +1 more source

Th17 Cells Paradoxical Roles in Melanoma and Potential Application in Immunotherapy

Frontiers in Immunology, 2019
The progressive infiltration of immune cells is associated with the progression of melanoma. Specifically, Th17 cells in melanoma microenvironment have both antitumor and protumor effects.
Chen Chen, Feng-Hou Gao
semanticscholar   +1 more source

Th17 cells and skin diseases

Japanese Journal of Clinical Immunology, 2012
Th17 cells have crucial functions in host defense, and dysregulated Th17 responses mediate a variety of autoimmune and inflammatory conditions. Th17 cells coexpress IL-22, and its receptor is expressed on epidermal keratinocytes. IL-17 and /or IL-22 induce the production of certain cytokines, chemokines and antimicrobial peptides by keratinocytes, and ...
openaire   +3 more sources