Results 11 to 20 of about 10,554,980 (260)
Induction and effector functions of TH17 cells [PDF]
Nature, 2008 Estelle Bettelli +3 more
openalex +2 more sources
Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells
EMBO Reports, 2022 Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial.
Aleksandra Lopez Krol +14 more
semanticscholar +1 more source
TCR-independent functions of Th17 cells mediated by the synergistic actions of cytokines of the IL-12 and IL-1 families. [PDF]
PLoS ONE, 2017 The development of Th17 cells is accompanied by the acquisition of responsiveness to both IL-12 and IL-23, cytokines with established roles in the development and/or function of Th1 and Th17 cells, respectively. IL-12 signaling promotes antigen-dependent
Yun Kyung Lee +5 more
doaj +1 more source
Th17 Cells in Periodontitis and Its Regulation by A20
Frontiers in Immunology, 2021 Periodontitis is a prevalent chronic disease that results in loss of periodontal ligament and bone resorption. Triggered by pathogens and prolonged inflammation, periodontitis is modulated by the immune system, especially pro-inflammatory cells, such as ...
Ning Huang, Hao Dong, Yuqi Luo, Bin Shao
doaj +1 more source
Frontiers in Immunology, 2021 Pathogenic Th17 cells are critically involved in many autoimmune diseases, while non-pathogenic Th17 cells are more immune regulatory. Understanding the mechanisms of the induction and maintenance of pathogenic Th17 cells will benefit the development of ...
Ping Li +6 more
doaj +1 more source
Th17 Cells in Viral Infections—Friend or Foe?
Cells, 2021 Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers.
Iury Amancio Paiva +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann +28 more
doaj +1 more source
The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone
Frontiers in Immunology, 2023 T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body. Immune–endocrine interactions are vital in endocrine organs during pathological states.
Changyan Zi +3 more
doaj +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. [PDF]
PLoS ONE, 2015 Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.
Qing Yu, Xiang-ming Lou, Yan He
doaj +1 more source