Results 11 to 20 of about 197,134 (290)
Current Opinion in Immunology, 2023 At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment.
Theodora, Agalioti +2 more
openaire +2 more sources
Th17 Cells in Viral Infections—Friend or Foe?
Cells, 2021 Th17 cells are recognized as indispensable in inducing protective immunity against bacteria and fungi, as they promote the integrity of mucosal epithelial barriers.
Iury Amancio Paiva +3 more
doaj +1 more source
Metabolic regulation of regulatory T cell development and function [PDF]
, 2014 It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves +68 more
core +8 more sources
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. [PDF]
PLoS ONE, 2015 Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.
Qing Yu, Xiang-ming Lou, Yan He
doaj +1 more source
Frontiers in Immunology, 2022 Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann +28 more
doaj +1 more source
Arthritis Research & Therapy, 2008 The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders.
openaire +2 more sources
The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone
Frontiers in Immunology, 2023 T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body. Immune–endocrine interactions are vital in endocrine organs during pathological states.
Changyan Zi +3 more
doaj +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source
Human Th17 cells: Are they different from murine Th17 cells? [PDF]
European Journal of Immunology, 2009 AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO +4 more
openaire +3 more sources
BBA Advances, 2023 Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor cells (MDSCs) can promote the differentiation of Th17 cells in chronic inflammatory autoimmune injury.
Li Lu +6 more
doaj +1 more source