Results 21 to 30 of about 10,554,980 (260)
Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. [PDF]
, 2017 Granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by T helper 17 (Th17) cells plays an essential role in autoimmune diseases. Transcriptional regulation of Th17 cell differentiation has been extensively studied, but post-transcriptional ...
Adamiak, William +5 more
core +3 more sources
Enhanced mechanical heterogeneity of cell collectives due to temporal fluctuations in cell elasticity [PDF]
Phys. Rev. E 107, 014401 (2023), 2022 Cells are dynamic systems characterized by temporal variations in biophysical properties such as stiffness and contractility. Recent studies show that the recruitment and release of actin filaments into and out of the cell cortex - a network of proteins underneath the cell membrane - leads to cell stiffening prior to division and softening immediately ...
arxiv +1 more source
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]
, 2017 In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus +6 more
core +2 more sources
Phenotypic and functional features of human Th17 cells
Journal of Experimental Medicine, 2007 T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato +15 more
semanticscholar +1 more source
PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
Nature Communications, 2020 Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa ...
Mingcan Yu +7 more
semanticscholar +1 more source
Science immunology, 2020 Ongoing classic IL-6 receptor signaling is required to maintain the TH17 program, acting upstream of IL-23 to sustain RORγt expression. TH17 sustenance via IL-6 The pathogenic role of the TH17 subset of CD4+ T cells in multiple immune-mediated diseases ...
Stacey N. Harbour +9 more
semanticscholar +1 more source
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression
Cell Reports, 2016 Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste +9 more
doaj +1 more source
T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis [PDF]
, 2020 Multiple sclerosis (MS) is a chronic neurodegenerative disease characterized by the progressive loss of axonal myelin in several areas of the central nervous system (CNS) that is responsible for clinical symptoms such as muscle spasms, optic neuritis ...
Amormino, Carola +4 more
core +1 more source
Cell Reports, 2021 Summary: Pathogenic Th17 cells drive inflammation in autoimmune disease, yet the molecular programming underlying Th17 cell pathogenicity remains insufficiently understood.
Kathryne E. Marks +5 more
doaj