Results 31 to 40 of about 10,582,664 (406)
Brain, Behavior, and Immunity, 2018 T helper 17 (Th17) cells have recently been implicated in depression, which adds to the list of several other diseases of the central nervous system (CNS) that are already known to involve Th17 cells. In CNS diseases, it is thought that the signature cytokine produced by Th17 cells, interleukin-17A (IL-17A), mediates the detrimental effects of Th17 ...
Jeffrey A. Lowell, Eleonore Beurel
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Cell Reports, 2021 Summary: Pathogenic Th17 cells drive inflammation in autoimmune disease, yet the molecular programming underlying Th17 cell pathogenicity remains insufficiently understood.
Kathryne E. Marks +5 more
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BMC Pulmonary Medicine, 2019 Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
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miRNAs Alter T Helper 17 Cell Fate in the Pathogenesis of Autoimmune Diseases
Frontiers in Immunology, 2021 T helper 17 (Th17) cells are characterized by the secretion of the IL-17 cytokine and are essential for the immune response against bacterial and fungal infections.
Junxia Huang, Xinzhi Xu, Ji Yang
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Th17 cells and HIV infection [PDF]
Current Opinion in HIV and AIDS, 2010 This review summarizes the recent literature about the potential perturbation and role of Th17 cells in HIV pathogenesis. We discuss the recent findings on Th17 deficiency in HIV/simian immunodeficiency virus (SIV) infection and how this deficiency may impact the mucosal host defenses, potentially contributing to chronic immune activation.Th17 cells ...
Derya Unutmaz, Aimee ElHed
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Survival Proteins Encourage Human T Helper 17 Cells to Escape from Cell Death
Proceedings, 2018 IL-17 producing T helper 17 (Th17) cells are identified as a distinct subset of CD4+ T helper cells. They play a role in immune response. Abnormal regulation of Th17 cells can play a role in different type of pathologies such autoimmune diseases and ...
Tuğçe Çimen, Ayten Nalbant
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Journal of Immunology Research, 2021 Several studies showed that IL-17A was significantly increased in nasal polyps (NPs). However, the source and characteristics of IL-17A-producing cells in NPs were not fully understood.
Guangfu Xu +3 more
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Science immunology, 2020 Ongoing classic IL-6 receptor signaling is required to maintain the TH17 program, acting upstream of IL-23 to sustain RORγt expression. TH17 sustenance via IL-6 The pathogenic role of the TH17 subset of CD4+ T cells in multiple immune-mediated diseases ...
Stacey N. Harbour +9 more
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The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Viruses, 2017 The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and adaptive immunity against fungal and bacterial infections at skin and mucosal ...
Vanessa Sue Wacleche +3 more
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Frontiers in Immunology, 2023 At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor ...
Yuanyuan Pan +6 more
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