Results 31 to 40 of about 10,836,682 (383)
Preferential recruitment of Th17 cells to cervical cancer via CCR6-CCL20 pathway. [PDF]
PLoS ONE, 2015 Our previous studies suggest that Th17 cells accumulate within tumor tissues and correlate with recurrence of cervical cancer patients. However, the source of the increased tumor-infiltrating Th17 cells remains poorly understood.
Qing Yu, Xiang-ming Lou, Yan He
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Frontiers in Immunology, 2022 Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs.
Hélène Jamann +28 more
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Arthritis Research & Therapy, 2008 The discovery in mice of a new lineage of CD4+ effector T helper (Th) cells that selectively produce IL-17 has provided exciting new insights into immune regulation, host defence, and the pathogenesis of autoimmune and other chronic inflammatory disorders.
openaire +2 more sources
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. [PDF]
, 2017 In both multiple sclerosis and experimental autoimmune encephalomyelitis (EAE), the C-C chemokine receptor 6 (CCR6) is critical for pathogenic T helper 17 (Th17) cell migration to the central nervous system (CNS).
Atasoy, Ulus +6 more
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The role of Th17 cells in endocrine organs: Involvement of the gut, adipose tissue, liver and bone
Frontiers in Immunology, 2023 T Helper 17 (Th17) cells are adaptive immune cells that play myriad roles in the body. Immune–endocrine interactions are vital in endocrine organs during pathological states.
Changyan Zi +3 more
doaj +1 more source
Journal of Experimental Medicine, 2006 Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 ...
Spencer C. Liang +6 more
semanticscholar +1 more source
Human Th17 cells: Are they different from murine Th17 cells? [PDF]
European Journal of Immunology, 2009 AbstractType 17 Th (Th17) cells have been identified as a distinct population of CD4+ effector T cells different from Th1 and Th2 cells. While the pre‐eminent cytokine of Th1 cells is IFN‐γ and that of Th2 cells is IL‐4, the distinctive cytokine of Th17 cells is IL‐17A.
ANNUNZIATO, FRANCESCO +4 more
openaire +3 more sources
BBA Advances, 2023 Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor cells (MDSCs) can promote the differentiation of Th17 cells in chronic inflammatory autoimmune injury.
Li Lu +6 more
doaj +1 more source
Phenotypic and functional features of human Th17 cells
Journal of Experimental Medicine, 2007 T helper (Th) 17 cells represent a novel subset of CD4+ T cells that are protective against extracellular microbes, but are responsible for autoimmune disorders in mice. However, their properties in humans are only partially known.
F. Annunziato +15 more
semanticscholar +1 more source
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
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