Results 41 to 50 of about 10,836,682 (383)
Purinergic Signaling as a Regulator of Th17 Cell Plasticity. [PDF]
PLoS ONE, 2016 T helper type 17 (Th17) lymphocytes, characterized by the production of interleukin-17 and other pro-inflammatory cytokines, are present in intestinal lamina propria and have been described as important players driving intestinal inflammation.
Dominique Fernández +17 more
doaj +1 more source
B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]
, 2013 We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall +74 more
core +7 more sources
Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. [PDF]
, 2017 Granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by T helper 17 (Th17) cells plays an essential role in autoimmune diseases. Transcriptional regulation of Th17 cell differentiation has been extensively studied, but post-transcriptional ...
Adamiak, William +5 more
core +3 more sources
BMC Pulmonary Medicine, 2019 Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj +1 more source
Frontiers in Immunology, 2023 At the turn of the century, researchers discovered a unique subtype of T helper cells that secretes IL-17 and defined it as Th17. The latest study found that Th17 cells play both positive and negative definitive roles in the regulation of antitumor ...
Yuanyuan Pan +6 more
doaj +1 more source
PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells
Nature Communications, 2020 Bone loss is a frequent but not universal complication of hyperparathyroidism. Using antibiotic-treated or germ-free mice, we show that parathyroid hormone (PTH) only caused bone loss in mice whose microbiota was enriched by the Th17 cell-inducing taxa ...
Mingcan Yu +7 more
semanticscholar +1 more source
Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]
, 2015 BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu +3 more
core +2 more sources
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression
Cell Reports, 2016 Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste +9 more
doaj +1 more source
International Journal of Molecular Sciences, 2019 Innate immunity represents the semi-specific first line of defense and provides the initial host response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive immunity, and both act highly regulated together to establish and ...
K. Bunte, T. Beikler
semanticscholar +1 more source
Science immunology, 2020 Ongoing classic IL-6 receptor signaling is required to maintain the TH17 program, acting upstream of IL-23 to sustain RORγt expression. TH17 sustenance via IL-6 The pathogenic role of the TH17 subset of CD4+ T cells in multiple immune-mediated diseases ...
Stacey N. Harbour +9 more
semanticscholar +1 more source