Results 51 to 60 of about 10,554,980 (260)
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
Cell, 2019 Lymphoid cells that produce IL-17 cytokines protect barrier tissues from pathogenic microbes, but are also prominent effectors of inflammation and autoimmune disease.
June-Yong Lee +17 more
semanticscholar +1 more source
Th17 Cells in Depression: Are They Crucial for the Antidepressant Effect of Ketamine?
Frontiers in Pharmacology, 2021 Background: Major depressive disorder is associated with inflammation and immune processes. Depressive symptoms correlate with inflammatory markers and alterations in the immune system including cytokine levels and immune cell function.
Meiying Cui +3 more
doaj +1 more source
Science Translational Medicine, 2018 Combined patient and animal model studies implicate microbiota-triggered TH17 cells as disease drivers and therapeutic targets in periodontitis. Probing periodontitis pathology Periodontitis is a common inflammatory disease that can lead to bone loss ...
N. Dutzan +18 more
semanticscholar +1 more source
Surface activity of cancer cells: the fusion of two cell aggregates [PDF]
arXiv, 2021 Although a good comprehension of how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been generated, the impact of collective migration on cellular rearrangement from subcellular to supracellular level remains less understood.
arxiv
Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing [PDF]
PNAS (2017), 2017 When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even genetically identical cells have differing responses to chemical signals.
arxiv +1 more source
Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury [PDF]
, 2019 We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1 ...
Basile, David P. +3 more
core +1 more source
Microbiome Dependent Regulation of Tregs and Th17 Cells in Mucosa
Frontiers in Immunology, 2019 Mammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex ...
P. Pandiyan +5 more
semanticscholar +1 more source
Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis
Frontiers in Immunology, 2019 In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells.
D. Cluxton +3 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: Understanding metabolic pathways that regulate Th17 development is important to broaden therapeutic options for Th17-mediated autoimmunity.
Boyoung Shin +6 more
doaj
Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]
, 2015 BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu +3 more
core +2 more sources