Results 71 to 80 of about 10,582,664 (406)
Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway. [PDF]
PLoS ONE, 2012 MSC display potent suppressive properties initially described a decade ago. More recently, MSC suppressive activities on T-cell effector pathways have been investigated.
Patricia Luz-Crawford +7 more
doaj +1 more source
Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 [PDF]
, 2014 Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype by increasing expression of IL-23 ...
Kishi, Yasuhiro +7 more
core +1 more source
Science-Business eXchange, 2013 Constellation Pharmaceuticals has established a connection between BET bromodomain proteins and pathogenic T helper type 17 cells. The findings hint at potential therapeutic opportunities for this epigenetic target class in autoimmunity and inflammatory disease.
openaire +2 more sources
Surface activity of cancer cells: the fusion of two cell aggregates [PDF]
arXiv, 2021 Although a good comprehension of how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been generated, the impact of collective migration on cellular rearrangement from subcellular to supracellular level remains less understood.
arxiv
Cell-to-cell variation sets a tissue-rheology-dependent bound on collective gradient sensing [PDF]
PNAS (2017), 2017 When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even genetically identical cells have differing responses to chemical signals.
arxiv +1 more source
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]
, 2017 IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri +8 more
core +1 more source
Science Translational Medicine, 2018 Combined patient and animal model studies implicate microbiota-triggered TH17 cells as disease drivers and therapeutic targets in periodontitis. Probing periodontitis pathology Periodontitis is a common inflammatory disease that can lead to bone loss ...
N. Dutzan +18 more
semanticscholar +1 more source
Current Opinion in Immunology, 2023 At mucosal barriers, the T helper 17 (TH17) cell population plays a fundamental role in controlling tissue homeostasis. The adaptability of this population to a more pro-inflammatory or anti-inflammatory function - that is, their functional plasticity and consequently heterogeneity - primarily depends on the environment.
Theodora, Agalioti +2 more
openaire +2 more sources
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis
Frontiers in Immunology, 2021 Epinephrine is a hormone secreted primarily by medullary cells of the adrenal glands which regulates permeability of blood–brain barrier (BBB). Recent studies showed signaling by epinephrine/epinephrine receptor in T cells is involved in autoimmune ...
Pinguang Yang +8 more
doaj +1 more source