Results 81 to 90 of about 197,134 (290)
Changes of Peripheral Th17 Cells Subset in Overweight and Obese Children After Body Weight Reduction
Frontiers in Endocrinology, 2022 BackgroundObesity has been a growing problem in young patients leading to serious metabolic complications. There are many studies supporting the idea, that obesity should be considered as a chronic inflammation closely associated with immune system ...
Dorota Artemniak-Wojtowicz +4 more
doaj +1 more source
The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses. [PDF]
, 2019 T helper 17 cells (Th17) are critical for fighting infections at mucosal surfaces; however, they have also been found to contribute to the pathogenesis of multiple autoimmune diseases and have been targeted therapeutically.
Anderson, Mark S +6 more
core
Retinoic acid as a modulator of T cell immunity [PDF]
, 2016 Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system,
Bono, M.R. +5 more
core +1 more source
Advanced Science, EarlyView.Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu +15 more
wiley +1 more source
The Journal of Clinical InvestigationFemale individuals have an increased prevalence of many Th17 cell–mediated diseases, including asthma. Androgen signaling decreases Th17 cell–mediated airway inflammation, and Th17 cells rely on glutaminolysis.
Nowrin U. Chowdhury +23 more
doaj +1 more source
Upregulated TNFR Family Member Insufficient to Promote Apoptotic Cell Death in T Helper 17 Cells
Proceedings, 2018 Fas is the receptor of tumor necrosis family receptors (TNFR) and involves in apoptosis. Since discovery of T helper 17 cells (Th17) in 2005, which are defined as a new type of helper T cells, it has become clear that the dysregulated function Th17 cells
Tufan Utku Çalışkan, Ayten Nalbant
doaj +1 more source
CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells
iScience, 2020 Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey +3 more
doaj +1 more source
Cell Death and Disease, 2023 Background Hepatic ischemia-reperfusion injury (IRI) is considered as an effecting factor for hepatocellular carcinoma (HCC) recurrence. Th17/Treg cells are a pair of essential components in adaptive immune response in liver IRI, and forkhead box O1 ...
Haozhen Ren +10 more
doaj +1 more source
The role of the novel Th17 cytokine IL-26 in intestinal inflammation [PDF]
, 2008 Background and aims: Interleukin 26 (IL-26), a novel IL-10-like cytokine without a murine homologue, is expressed in T helper 1 (Th1) and Th17 cells. Currently, its function in human disease is completely unknown. The aim of this study was to analyse its
Auernhammer, Christoph J. +7 more
core +1 more source
Sox5 and Th17 cell differentiation
Oncotarget, 2015 Sox (SRY-related high-mobility-group (HMG)-box) transcription factors, which are comprised of 20 genes containing a conserved HMG DNA-binding domain, are divided into 8 groups (from A to H) according to structural homologies [reviewed in 1–2]. SoxC group, which is composed of Sox4, Sox11, and Sox12, has a HMG box domain and a transactivation domain and
Akira, Suto +2 more
openaire +2 more sources