Results 101 to 110 of about 709,386 (365)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis [PDF]

, 2014
Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study.
Brown, Gordon D, Drummond, Rebecca A, Kaplan, Daniel H, Reid, Delyth M, Wallace, Carol, Way, Sing Sing   +5 more
core   +2 more sources

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma. [PDF]

PLoS ONE, 2011
BackgroundTh17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the
Claire Galand, Sabrina Donnou, Lucile Crozet, Séverine Brunet, Valérie Touitou, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Sylvain Fisson   +8 more
doaj   +1 more source

Th17 lymphocytes and alternatively activated monocytes are upregulated in clinical sepsis [PDF]

Critical Care, 2011
Sepsis is a systemic inflammatory response triggered by infection. Inflammatory response is modulated during sepsis and upregulation and downregulation of cellular activity is observed, depending on the cells and functions evaluated. Nevertheless, the interaction of innate and adaptative immune responses has been little studied in clinical sepsis.
Eliezer Silva, Otelo Rigato, F Machado, MV Santos, Reinaldo Salomão, Mkc Brunialti   +5 more
openaire   +2 more sources

Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma [PDF]

, 2019
Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in ...
Allegra A., Allegra A. G., Di Salvo E., Gangemi S., Innao V., Musolino C., Pugliese M., Ventura-Spagnolo E.   +7 more
core   +1 more source

Immunopathogenesis of canine chronic ulcerative stomatitis. [PDF]

, 2020
Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven.
Anderson, JG, Bizikova, P, Ford, K, Jimenez, RJ, Kol, A, Murphy, BG, Stapelton, BP, Vasilatis, D, Villarreal, A   +8 more
core   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Mediators of Inflammation, 2020
Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression.
Cristina Aguilar-Flores, Octavio Castro-Escamilla, Elizabeth M. Ortega-Rocha, César Maldonado-García, Fermín Jurado-Santa Cruz, Gibrán Pérez-Montesinos, Alicia Lemini-López, Laura C. Bonifaz   +7 more
doaj   +1 more source

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source