Expansion, isolation and first characterization of bovine Th17 lymphocytes. [PDF]
Sci Rep, 2019 Interleukin 17A-producing T helper cells (Th17) are CD4+ T cells that are crucial to immunity to extracellular bacteria. The roles of these cells in the bovine species are poorly defined, because the characterization of bovine Th17 cells lags behind for ...
Cunha P +5 more
europepmc +11 more sources
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. [PDF]
J Clin Invest, 2020 Immune microenvironment plays a critical role in lung cancer control versus progression and metastasis. In this investigation, we explored the impact of tumor-infiltrating-lymphocyte subpopulations on lung cancer biology by studying in vitro co-cultures,
Salazar Y +22 more
europepmc +7 more sources
Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence [PDF]
Frontiers in Neurology, 2019 Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons, appearance of Lewy bodies and presence of neuroinflammation.
Elisa Storelli +4 more
doaj +3 more sources
The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases. [PDF]
Arch Immunol Ther Exp (Warsz), 2015 The end of twentieth century has introduced some changes into T helper (Th) cells division. The identification of the new subpopulation of T helper cells producing IL-17 modified model of Th1–Th2 paradigm and it was named Th17.
Tabarkiewicz J +4 more
europepmc +7 more sources
Changes in Th9 and Th17 lymphocytes and functional cytokines and their relationship with thyroid-stimulating hormone receptor antibodies at different stages of graves' disease. [PDF]
Front Immunol, 2022 Objective Graves’ disease (GD) is an organ-specific autoimmune disease characterized by the production of thyroid-stimulating antibodies (TSAb). The newly discovered CD4+ T helper cells, Th9 and Th17 lymphocytes, have been confirmed to be closely ...
Ren X, Chen H.
europepmc +2 more sources
Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs. [PDF]
Int J Mol Sci, 2021 Amyotrophic lateral sclerosis (ALS) is a progressive disease leading to the degeneration of motor neurons (MNs). Neuroinflammation is involved in the pathogenesis of ALS; however, interactions of specific immune cell types and MNs are not well studied ...
Jin M +5 more
europepmc +2 more sources
High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes. [PDF]
Bioengineered, 2021 High altitude hypoxia (HAH) involves the pathogenesis of ulcerative colitis (UC) and gastrointestinal erosions. However, the mechanism of effects of HAH in colitis remains controversial.
Gamah M +9 more
europepmc +2 more sources
Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance Antibodies against neuronal receptors and synaptic proteins are associated with a group of ill-defined central nervous system (CNS) autoimmune diseases named autoimmune encephalitides (AE), characterized by an abrupt onset of seizures and ...
Platt MP +6 more
europepmc +2 more sources
Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion. [PDF]
Sci Rep, 2020 Chronic exposure to environmental pollutants is often associated with systemic inflammation. As such, cigarette smoking contributes to inflammation and lung diseases by inducing senescence of pulmonary cells such as pneumocytes, fibroblasts, and ...
Baskara I +10 more
europepmc +2 more sources
Interleukin-26, preferentially produced by TH17 lymphocytes, regulates CNS barrier function. [PDF]
Neurol Neuroimmunol Neuroinflamm, 2020 Objective To investigate the involvement of interleukin (IL)-26 in neuroinflammatory processes in multiple sclerosis (MS), in particular in blood-brain barrier (BBB) integrity.
Broux B +19 more
europepmc +2 more sources