Results 11 to 20 of about 113,223 (329)

Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis. [PDF]

Mol Autism, 2021
Abstract Background Immune system dysfunction has been proposed to play a critical role in the pathophysiology of autism spectrum disorders (ASD). Conflicting reports of lymphocyte subpopulation abnormalities have been described in numerous studies of patients with ASD.
Ellul P, Ellul P, Rosenzwajg M, Peyre H, Fourcade G, Mariotti-Ferrandiz E, Trebossen V, Klatzmann D, Delorme R.   +8 more
europepmc   +7 more sources

Expansion, isolation and first characterization of bovine Th17 lymphocytes. [PDF]

Sci Rep, 2019
AbstractInterleukin 17A-producing T helper cells (Th17) are CD4+ T cells that are crucial to immunity to extracellular bacteria. The roles of these cells in the bovine species are poorly defined, because the characterization of bovine Th17 cells lags behind for want of straightforward cultivation and isolation procedures.
Cunha P, Vern YL, Gitton C, Germon P, Foucras G, Rainard P.   +5 more
europepmc   +8 more sources

Th1, Th2 and Th17 lymphocytes in autoimmune thyreopathies [PDF]

Vnitřní lékařství, 2021
Among the most common organ-specific autoimmune diseases are autoimmune thyreopathies. We have focused on the importance of Th1, Th2 and Th17 lymphocytes in autoimmune thyroiditis (AT). The cohort consisted of 136 treated patients in the full clinical course of AT (24 men, mean age 41.0±16.8 years and 112 women, mean age 44.6±17.6 years).
Karolína Absolonová, Petr Matucha, I Šterzl   +2 more
openalex   +3 more sources

Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs. [PDF]

Int J Mol Sci, 2021
Jin M, Akgün K, Ziemssen T, Kipp M, Günther R, Hermann A.   +5 more
europepmc   +3 more sources

Th17 and Th1 Lymphocytes in Oligoarticular Juvenile Idiopathic Arthritis [PDF]

Frontiers in Immunology, 2019
In the last years much attention has focused on the Th17 and Th1 phenotypes and on their pathogenic role in juvenile idiopathic arthritis, investigating how the cytokines produced by T helper cells act on resident cells on the synovia and which signal transduction pathways regulate Th17 cells proliferation and plasticity.
Laura Maggi, Alessio Mazzoni, Rolando Cimaz, Francesco Liotta, Francesco Annunziato, Lorenzo Cosmi   +5 more
openalex   +6 more sources

Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing [PDF]

Clinical Cancer Research, 2008
Abstract Purpose: Pathologic examination of prostate glands removed from patients with prostate cancer commonly reveals infiltrating CD4+ and CD8+ T cells. Little is known about the phenotype of these cells, despite accumulating evidence suggesting a potential role for chronic inflammation in the etiology of prostate cancer.
Karen S. Sfanos, Tullia C. Bruno, Charles H. Maris, Lauren Xu, Christopher J. Thoburn, Angelo M. De Marzo, Alan K. Meeker, William B. Isaacs, Charles G. Drake   +8 more
openalex   +4 more sources

Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. [PDF]

J Clin Invest, 2020
Immune microenvironment plays a critical role in lung cancer control versus progression and metastasis. In this investigation, we explored the effect of tumor-infiltrating lymphocyte subpopulations on lung cancer biology by studying in vitro cocultures, in vivo mouse models, and human lung cancer tissue.
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R.   +22 more
europepmc   +6 more sources

Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma

Biomedicines, 2021
Characterization of tumor associated lymphocytes (TILs) in tumor lesions is important to obtain a clear definition of their prognostic value and address novel therapeutic opportunities.
Anna Tosi, Lavinia Nardinocchi, Maria Luigia Carbone, Lorena Capriotti, Elena Pagani, Simona Mastroeni, Cristina Fortes, Fernanda Scopelliti, Caterina Cattani, Francesca Passarelli, Antonio Rosato, Stefania D’Atri, Cristina Maria Failla, Andrea Cavani   +13 more
doaj   +1 more source

The potential role of Th17 lymphocytes in patients with psoriasis. [PDF]

An Bras Dermatol, 2018
Psoriasis is a chronic inflammatory disorder, characterized by increased keratinocyte proliferation due to abnormal differentiation of basal keratinocytes. The etiology of the disease is unclear, and according to the survey results, it is hypothesized that a combination of genetic and environmental factors prompts an abnormal immune response in ...
Mansouri M, Mansouri P, Raze AA, Jadali Z.   +3 more
europepmc   +7 more sources

Endotoxin tolerance modulates TREG and TH17 lymphocytes protecting septic mice. [PDF]

Oncotarget, 2019
Background: Tolerance induces a regulated immune response to infection. We hypothesized that tolerance induction modulated profile of T regulatory cell (Treg) and T lymphocyte 17 (Th17) cells and is related cytokine released in septic animals. Methods: Male black C57/6 mice received subcutaneous (s.c.) injections of lipopolysaccharide (LPS) (1 mg/kg ...
Andrade MMC, Ariga SSK, Barbeiro DF, Barbeiro HV, Pimentel RN, Petroni RC, Soriano FG.   +6 more
europepmc   +4 more sources