Results 31 to 40 of about 306,117 (176)

Role of Th17 lymphocytes in pathogenesis of colorectal cancer

Postępy Higieny i Medycyny Doświadczalnej, 2014
Colorectal cancer (CRC) is estimated to be the first leading cause of death from cancer among men and women in the EU. Every year in Poland, 15,254 cases of CRC are diagnosed, and 10,501 patients die of the disease, making it the second leading cause of death from cancer.
Jacek, Karczewski, Małgorzata, Mazur, Anna, Rychlewska-Hańczewska, Zygmunt, Adamski   +3 more
openaire   +2 more sources

miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway

Biochemistry Research International, 2022
Objective. To study the mechanism by which miR-21 regulates the differentiation and function of Th17/Treg cells in sepsis. Methods. A rat model with sepsis was made by cecal ligation and puncture (CLP). Then, some of the septic rats were transfected with
Cheng Liu, Qi Zou
doaj   +1 more source

Trypanosomiasis-induced Th17-like immune responses in carp [PDF]

, 2010
Background - In mammalian vertebrates, the cytokine interleukin (IL)-12 consists of a heterodimer between p35 and p40 subunits whereas interleukin-23 is formed by a heterodimer between p19 and p40 subunits.
B M Lidy Verburg-van Kemenade, Verburg-van Kemenade, B.M.L., Chadzinska Magdalena, Wiegertjes Geert F., Chadzinska, M.K., Huub F. J. Savelkoul, Scheer Marleen, Savelkoul, H.F.J., Scheer, M.H., Geert F Wiegertjes, Savelkoul Huub F. J., Bird, S., Maria J. S. L. Pontes, Ribeiro, Carla M. S., B. M. Lidy Verburg-van Kemenade, Wiegertjes, G.F., Savelkoul, Huub F. J., Carla M S Ribeiro, Scheer, Marleen, Marleen Scheer, Verburg-van Kemenade B. M. Lidy, Steve Bird, Maria J S L Pontes, Huub F J Savelkoul, Pontes, Maria J. S. L., Verburg-van Kemenade, B. M. Lidy, Ribeiro, C.M.S., Wiegertjes, Geert F., Bird Steve, Magdalena Chadzinska, Carla M. S. Ribeiro, Pontes, M.J.S.L., Ribeiro Carla M. S., Chadzinska, Magdalena, Pontes Maria J. S. L., Bird, Steve, Geert F. Wiegertjes   +36 more
core   +2 more sources

Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining [PDF]

BIO-PROTOCOL, 2016
In vitro Th17 (α, β T helper cell which produce IL-17A, IL-17F and IL-22) differentiation has been routinely used for functional T cells studies. Here we describe a method for Th17 cell differentiation.
Pawan Kumar, Jay Kolls
openaire   +3 more sources

The IL23R R381Q gene variant protects against immune-mediated diseases by impairing IL-23-induced Th17 effector response in humans [PDF]

, 2011
IL-23 and Th17 cells are key players in tissue immunosurveillance and are implicated in human immune-mediated diseases. Genome-wide association studies have shown that the IL23R R381Q gene variant protects against psoriasis, Crohn's disease and ...
Di Meglio, P, Chung-Ching Chu, Francesca Capon, Di Meglio, Paola, Napolitano, Luca, Napolitano, L, Ketty Peris, Di Cesare, Antonella, Villanova, Federica, Villanova, F, Richard C. Trembath, Isabella Tosi, Paola Di Meglio, Richard C Trembath, Laggner, Ute, Chu, Chung-Ching, Chu, CC, Capon, Francesca, Federica Villanova, Frank O Nestle, Nestle, FO, Peris, K, Nestle, Frank O., Antonella Di Cesare, Peris, Ketty, Trembath, RC, Laggner, U, Tosi, Isabella, Luca Napolitano, Capon, F, Frank O. Nestle, Ute Laggner, Trembath, Richard C., Di Cesare, A, Tosi, I   +34 more
core   +2 more sources

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Cell Reports, 2017
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu   +7 more
doaj   +1 more source

Pathogenicity of In Vivo Generated Intestinal Th17 Lymphocytes is IFNγ Dependent [PDF]

Journal of Crohn's and Colitis, 2018
T helper 17 [Th17] cells are crucially involved in the immunopathogenesis of inflammatory bowel diseases in humans. Nevertheless, pharmacological blockade of interleukin 17A [IL17A], the Th17 signature cytokine, yielded negative results in patients with Crohn's disease [CD], and attempts to elucidate the determinants of Th17 cells' pathogenicity in the
Nizzoli, Giulia, Burrello, Claudia, Cribiù, Fulvia Milena, Lovati, Giulia, Ercoli, Giulia, Botti, Fiorenzo, Trombetta, Elena, Porretti, Laura, Todoerti, Katia, Neri, Antonino, Giuffrè, Maria Rita, Geginat, Jens, Vecchi, Maurizio, Rescigno, Maria, Paroni, Moira, Caprioli, Flavio, Facciotti, Federica   +16 more
openaire   +2 more sources

IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA

Медицинская иммунология, 2019
Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied.
T. I. Vitkina, T. P. Novgorodtseva, E. P. Kalinina, E. G. Lobanova, M. V. Antonyuk   +4 more
doaj   +3 more sources

Th17 Cells, Glucocorticoid Resistance, and Depression

Cells, 2023
Depression is a severe mental disorder that disrupts mood and social behavior and is one of the most common neuropsychological symptoms of other somatic diseases.
Julia N. Khantakova, Anastasia Mutovina, Kseniya A. Ayriyants, Natalia P. Bondar   +3 more
doaj   +1 more source

The use of wavelength modulated Raman spectroscopy in label-free identification of T lymphocyte subsets, natural killer cells and dendritic cells [PDF]

, 2015
This work was funded by a Cancer Research United Kingdom, Engineering and Physical Sciences Research Council (grant EP/J01771X/1), Medical Research Council and Department of Health England Imaging Programme (MC, MM KD), and by A European Union FAMOS ...
Barbosa, Joao, Campbell, Elaine Catherine, Naomi McReynolds (741700), Michael Mazilu (426524), Dholakia, Kishan, Kishan Dholakia, João Barbosa (741701), Simon J. Powis (319937), Elaine C. Campbell (319934), Mazilu Michael, McReynolds Naomi, Dholakia Kishan, McReynolds, Naomi, Simon J Powis, Campbell Elaine C., Powis Simon J., Elaine C Campbell, Mingzhou Chen, Naomi McReynolds, Kishan Dholakia (426528), Chen Mingzhou, João Barbosa, Mingzhou Chen (741699), Barbosa João, Michael Mazilu, Chen, Mingzhou, Mazilu, Michael, Powis, Simon John   +27 more
core   +2 more sources