Results 31 to 40 of about 79,137 (281)

miR-21 Regulates Immune Balance Mediated by Th17/Treg in Peripheral Blood of Septic Rats during the Early Phase through Apoptosis Pathway

Biochemistry Research International, 2022
Objective. To study the mechanism by which miR-21 regulates the differentiation and function of Th17/Treg cells in sepsis. Methods. A rat model with sepsis was made by cecal ligation and puncture (CLP). Then, some of the septic rats were transfected with
Cheng Liu, Qi Zou
doaj   +1 more source

Role of Th17 lymphocytes in pathogenesis of colorectal cancer

Postępy Higieny i Medycyny Doświadczalnej, 2014
Colorectal cancer (CRC) is estimated to be the first leading cause of death from cancer among men and women in the EU. Every year in Poland, 15,254 cases of CRC are diagnosed, and 10,501 patients die of the disease, making it the second leading cause of death from cancer.
Jacek, Karczewski, Małgorzata, Mazur, Anna, Rychlewska-Hańczewska, Zygmunt, Adamski   +3 more
openaire   +2 more sources

Lymphocyte Isolation, Th17 Cell Differentiation, Activation, and Staining [PDF]

BIO-PROTOCOL, 2016
In vitro Th17 (α, β T helper cell which produce IL-17A, IL-17F and IL-22) differentiation has been routinely used for functional T cells studies. Here we describe a method for Th17 cell differentiation.
Pawan Kumar, Jay Kolls
openaire   +3 more sources

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Cell Reports, 2017
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu   +7 more
doaj   +1 more source

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Harnett, M.M., Pineda, Miguel, McGrath, Mairi, Al-Riyami, Lamyaa, Pineda, M.A., Harnett, W., Pauline C. Smith, Lamyaa Al-Riyami, Harnett, Margaret, Miguel A. Pineda, Smith, P.C., Smith, Pauline, J. Alastair Gracie, Harnett, William, McGrath, M.A., Rzepecka, J., Gracie, Alastair, Rzepecka, Justyna, Margaret M. Harnett, Al-Riyami, L., Gracie, J.A., Justyna Rzepecka, Mairi A. McGrath, William Harnett   +23 more
core   +1 more source

IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA

Медицинская иммунология, 2019
Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied.
T. I. Vitkina, T. P. Novgorodtseva, E. P. Kalinina, E. G. Lobanova, M. V. Antonyuk   +4 more
doaj   +3 more sources

Th17 Cells, Glucocorticoid Resistance, and Depression

Cells, 2023
Depression is a severe mental disorder that disrupts mood and social behavior and is one of the most common neuropsychological symptoms of other somatic diseases.
Julia N. Khantakova, Anastasia Mutovina, Kseniya A. Ayriyants, Natalia P. Bondar   +3 more
doaj   +1 more source

Pathogenicity of In Vivo Generated Intestinal Th17 Lymphocytes is IFNγ Dependent [PDF]

Journal of Crohn's and Colitis, 2018
T helper 17 [Th17] cells are crucially involved in the immunopathogenesis of inflammatory bowel diseases in humans. Nevertheless, pharmacological blockade of interleukin 17A [IL17A], the Th17 signature cytokine, yielded negative results in patients with Crohn's disease [CD], and attempts to elucidate the determinants of Th17 cells' pathogenicity in the
Nizzoli, Giulia, Burrello, Claudia, Cribiù, Fulvia Milena, Lovati, Giulia, Ercoli, Giulia, Botti, Fiorenzo, Trombetta, Elena, Porretti, Laura, Todoerti, Katia, Neri, Antonino, Giuffrè, Maria Rita, Geginat, Jens, Vecchi, Maurizio, Rescigno, Maria, Paroni, Moira, Caprioli, Flavio, Facciotti, Federica   +16 more
openaire   +2 more sources

Hepatic lymphocytes involved in the pathogenesis of pediatric and adult non-alcoholic fatty liver disease

Scientific Reports, 2021
The immune response is critical in NAFLD pathogenesis, but the liver infiltrate’s composition and the role of each T cell population is still up for debate.
Victoria Cairoli, Elena De Matteo, Daniela Rios, Carol Lezama, Marcela Galoppo, Paola Casciato, Eduardo Mullen, Cecilia Giadans, Gustavo Bertot, María Victoria Preciado, Pamela Valva   +10 more
doaj   +1 more source

Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticity.

PLoS ONE, 2011
In this work we analyzed the immune activation properties of different Bifidobacterium strains in order to establish their ability as inductors of specific effector (Th) or regulatory (Treg) responses. First, we determined the cytokine pattern induced by
Patricia López, Irene González-Rodríguez, Miguel Gueimonde, Abelardo Margolles, Ana Suárez   +4 more
doaj   +1 more source