Results 51 to 60 of about 306,117 (176)

T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity [PDF]

The Journal of Immunology, 2007
Abstract IL-17-producing T cells (Th17) have recently been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis. However, little is known about the transcription factors that regulate these cells. Although it is clear that the transcription factor T-
Anne R, Gocke, Petra D, Cravens, Li-Hong, Ben, Rehana Z, Hussain, Sara C, Northrop, Michael K, Racke, Amy E, Lovett-Racke   +6 more
openaire   +2 more sources

Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New

Clinical and Developmental Immunology, 2012
Pathogenic mechanisms underlying the development of systemic lupus erythematosus (SLE) are very complex and not yet entirely clarified. However, the pivotal role of T lymphocytes in the induction and perpetuation of aberrant immune response is well ...
Alessia Alunno, Elena Bartoloni, Onelia Bistoni, Giuseppe Nocentini, Simona Ronchetti, Sara Caterbi, Valentina Valentini, Carlo Riccardi, Roberto Gerli   +8 more
doaj   +1 more source

Differentiation of Th subsets inhibited by nonstructural proteins of respiratory syncytial virus is mediated by ubiquitination. [PDF]

PLoS ONE, 2014
Human respiratory syncytial virus (RSV), a major cause of severe respiratory diseases, constitutes an important risk factor for the development of subsequent asthma. However, the mechanism underlying RSV-induced asthma is poorly understood.
Ling Qin, Dan Peng, Chengping Hu, Yang Xiang, Yigang Zhou, Yurong Tan, Xiaoqun Qin   +6 more
doaj   +1 more source

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes [PDF]

Journal of Visualized Experiments, 2013
Th17 cells are a distinct subset of T cells that have been found to produce interleukin 17 (IL-17), and differ in function from the other T cell subsets including Th1, Th2, and regulatory T cells. Th17 cells have emerged as a central culprit in overzealous inflammatory immune responses associated with many autoimmune disorders. In this method we purify
Simone K, Bedoya, Tenisha D, Wilson, Erin L, Collins, Kenneth, Lau, Joseph, Larkin   +4 more
openaire   +2 more sources

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

Nature Communications, 2017
Spondyloarthritis is an inflammatory disease with Th17 cells implicated in the pathogenesis. Here the authors show that patients with spondyloarthritis have increased numbers of GM-CSF-secreting blood and synovial lymphocytes, Th17 or not, that carry a ...
M. H. Al-Mossawi, L. Chen, H. Fang, A. Ridley, J. de Wit, N. Yager, A. Hammitzsch, I. Pulyakhina, B. P. Fairfax, D. Simone, Yao Yi, S. Bandyopadhyay, K. Doig, R Gundle, B. Kendrick, F. Powrie, J. C. Knight, P. Bowness   +17 more
doaj   +1 more source

Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells

Frontiers in Cellular and Infection Microbiology, 2017
Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Mariángeles Noto Llana, Mariángeles Noto Llana, Sebastián H. Sarnacki, Sebastián H. Sarnacki, Andrea L. Morales, Andrea L. Morales, María del R. Aya Castañeda, María del R. Aya Castañeda, Mónica N. Giacomodonato, Mónica N. Giacomodonato, Guillermo Blanco, Guillermo Blanco, María C. Cerquetti, María C. Cerquetti   +13 more
doaj   +1 more source

Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma. [PDF]

PLoS ONE, 2011
BackgroundTh17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the
Claire Galand, Sabrina Donnou, Lucile Crozet, Séverine Brunet, Valérie Touitou, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Sylvain Fisson   +8 more
doaj   +1 more source

[Th17 lymphocytes in bacterial infections].

Postepy higieny i medycyny doswiadczalnej (Online), 2015
Th17 cells are a relatively newly discovered subpopulation of helper CD4+ T lymphocytes. It has been shown that these cells may contribute to tissue damage during certain inflammatory and autoimmune diseases and also play an important role in antitumor and antimicrobial, particularly antibacterial, immunity. Bacteria stimulate the Th17 response through
Lidia, Szulc-Dąbrowska, Małgorzata, Gieryńska, Daria, Depczyńska, Ada, Schollenberger, Felix N, Toka   +4 more
openaire   +1 more source

Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus

Clinical and Developmental Immunology, 2013
Dendritic cells (DCs) have a key role in the regulation of immune response. We herein explored, in patients with inflammatory diseases, the role of monocyte derived DC’s (mo-DCs) on the generation of Th17 and T regulatory (Treg) lymphocytes.
Lizbeth Estrada-Capetillo, Berenice Hernández-Castro, Adriana Monsiváis-Urenda, Crisol Alvarez-Quiroga, Esther Layseca-Espinosa, Carlos Abud-Mendoza, Lourdes Baranda, Ana Urzainqui, Francisco Sánchez-Madrid, Roberto González-Amaro   +9 more
doaj   +1 more source

Estado nutricional e suas relações com populações de linfócitos T e marcadores inflamatórios em indivíduos com diagnóstico recente de neoplasias hematológicas malignas [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2013.Neoplasias hematológicas compreendem um grupo heterogêneo de doenças, entre elas, destacam-se as ...
Oliveira, Paula Fernanda de
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