Results 61 to 70 of about 79,137 (281)

Senescent CD4+CD28− T Lymphocytes as a Potential Driver of Th17/Treg Imbalance and Alveolar Bone Resorption during Periodontitis [PDF]

, 2022
Senescent cells express a senescence-associated secretory phenotype (SASP) with a pro-inflammatory bias, which contributes to the chronicity of inflammation.
Cortez, C., Luis González-Osuna, Alfredo Sierra-Cristancho, Cafferata, E.A., Rolando Vernal, González Oosuna, Luis Gustavo, Vernal Astudillo, Rolando Marcelo, Sierra Cristancho, Alfredo José, Rojas Pérez, Carolina Isabel, González-Osuna, L., Carvajal Pavez, Paola Lorena, Emilio A. Cafferata, Vernal, R., Cafferata Chea, Emilio Alfredo, Rojas, C., Melgar-Rodríguez, S., Carvajal, P., Cristian Cortez, Melgar Rodríguez, Samanta Azucena, Cortez, Cristian, Sierra-Cristancho, A., Paola Carvajal, Samanta Melgar-Rodríguez, Carolina Rojas   +23 more
core   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

Th17 cells are involved in the local control of tumor progression in primary intraocular lymphoma. [PDF]

PLoS ONE, 2011
BackgroundTh17 cells play an important role in the pathogenesis of many autoimmune diseases, but despite some reports of their antitumor properties, too little is known about their presence and role in cancers. Specifically, knowledge is sparse about the
Claire Galand, Sabrina Donnou, Lucile Crozet, Séverine Brunet, Valérie Touitou, Hanane Ouakrim, Wolf Herman Fridman, Catherine Sautès-Fridman, Sylvain Fisson   +8 more
doaj   +1 more source

Estado nutricional e suas relações com populações de linfócitos T e marcadores inflamatórios em indivíduos com diagnóstico recente de neoplasias hematológicas malignas [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Nutrição, Florianópolis, 2013.Neoplasias hematológicas compreendem um grupo heterogêneo de doenças, entre elas, destacam-se as ...
Oliveira, Paula Fernanda de
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells

Frontiers in Cellular and Infection Microbiology, 2017
Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Mariángeles Noto Llana, Mariángeles Noto Llana, Sebastián H. Sarnacki, Sebastián H. Sarnacki, Andrea L. Morales, Andrea L. Morales, María del R. Aya Castañeda, María del R. Aya Castañeda, Mónica N. Giacomodonato, Mónica N. Giacomodonato, Guillermo Blanco, Guillermo Blanco, María C. Cerquetti, María C. Cerquetti   +13 more
doaj   +1 more source

[Th17 lymphocytes in bacterial infections].

Postepy higieny i medycyny doswiadczalnej (Online), 2015
Th17 cells are a relatively newly discovered subpopulation of helper CD4+ T lymphocytes. It has been shown that these cells may contribute to tissue damage during certain inflammatory and autoimmune diseases and also play an important role in antitumor and antimicrobial, particularly antibacterial, immunity. Bacteria stimulate the Th17 response through
Lidia, Szulc-Dąbrowska, Małgorzata, Gieryńska, Daria, Depczyńska, Ada, Schollenberger, Felix N, Toka   +4 more
openaire   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources

Induction of Th17 Lymphocytes and Treg Cells by Monocyte-Derived Dendritic Cells in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus

Clinical and Developmental Immunology, 2013
Dendritic cells (DCs) have a key role in the regulation of immune response. We herein explored, in patients with inflammatory diseases, the role of monocyte derived DC’s (mo-DCs) on the generation of Th17 and T regulatory (Treg) lymphocytes.
Lizbeth Estrada-Capetillo, Berenice Hernández-Castro, Adriana Monsiváis-Urenda, Crisol Alvarez-Quiroga, Esther Layseca-Espinosa, Carlos Abud-Mendoza, Lourdes Baranda, Ana Urzainqui, Francisco Sánchez-Madrid, Roberto González-Amaro   +9 more
doaj   +1 more source