Results 61 to 70 of about 306,117 (176)

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1 [PDF]

, 2010
If insufficiently treated, Lyme borreliosis can evolve into an inflammatory disorder affecting skin, joints, and the CNS. Early innate immunity may determine host responses targeting infection. Thus, we sought to characterize the immediate cytokine storm
Nicole Darsow, Kind, Peter, Rudloff, Ina, Klaus-Peter Hunfeld, Katharina Horn, Itamar Goren, Urs Christen, Kraiczy Peter, Horn Katharina, Pfeilschifter, Josef (Prof. Dr.), Mühl Heiko, Koehl Ulrike, Peter Kind, Goren Itamar, Pfeilschifter, Josef, Peter Kraiczy, Rudloff Ina, Goren, Itamar, Mühl, Heiko, Darsow, Nicole, Christen Urs, Kraiczy, Peter, Christen, Urs, Holdener, Martin, Horn, Katharina, Hunfeld, Klaus-Peter, Ulrike Koehl, Hunfeld Klaus-Peter, Heiko Mühl, Ina Rudloff, Malte Bachmann, Martin Holdener, Holdener Martin, Koehl, Ulricke, Bachmann Malte, Darsow Nicole, Kind Peter, Köhl, Ulrike, Josef Pfeilschifter, Bachmann, Malte, Pfeilschifter Josef   +40 more
core   +1 more source

Insight Into Non-Pathogenic Th17 Cells in Autoimmune Diseases

Frontiers in Immunology, 2018
Th17 cells are generally considered to be positive regulators of immune responses because they produce pro-inflammatory cytokines, including IL-17A, IL-17F, and IL-22.
Xinyu Wu, Xinyu Wu, Jie Tian, Shengjun Wang, Shengjun Wang   +4 more
doaj   +1 more source

Association of Pathogenic Th17 Cells with the Disease Severity and Its Potential Implication for Biological Treatment Selection in Psoriasis Patients

Mediators of Inflammation, 2020
Psoriasis is an inflammatory autoimmune disease characterized by cutaneous lesions in plaques. It has been proposed that the immune response has a key role in the disease progression.
Cristina Aguilar-Flores, Octavio Castro-Escamilla, Elizabeth M. Ortega-Rocha, César Maldonado-García, Fermín Jurado-Santa Cruz, Gibrán Pérez-Montesinos, Alicia Lemini-López, Laura C. Bonifaz   +7 more
doaj   +1 more source

Th17 and non-Th17 interleukin-17-expressing cells in chronic lymphocytic leukemia: delineation, distribution, and clinical relevance [PDF]

Haematologica, 2011
The levels and clinical relevance of Th17 cells and other interleukin-17-producing cells have not been analyzed in chronic lymphocytic leukemia. The objective of this study was to quantify blood and tissue levels of Th17 and other interleukin-17-producing cells in patients with this disease and correlate blood levels with clinical outcome.Intracellular
Jain, Preetesh, Javdan, Mohammad, Feger, Franziska K., Chiu, Pui Yan, Sison, Cristina, Damle, Rajendra N., Bhuiya, Tawfiqul A., Sen, Filiz, Abruzzo, Lynne V., Burger, Jan A., Rosenwald, Andreas, Allen, Steven L., Kolitz, Jonathan E., Rai, Kanti R., Chiorazzi, Nicholas, Sherry, Barbara   +15 more
openaire   +3 more sources

Relationship between mucosal TNF-α expression and Th1, Th17, Th22 and Treg responses in Helicobacter pylori infection

AMB Express, 2022
Key points Expression of TNF-α was significantly increased in the PUD group than the gastritis group. Notably, TNF-α expression had a significant positive correlation with the frequency of Th1/Th17/Th22 lymphocytes in the PUD group.
Ghorbanali Rahimian, Milad Shahini Shams Abadi, Yousef Mirzaei, Ali Hussein Mer, Reza Ahmadi, Fatemeh Azadegan-Dehkordi   +5 more
doaj   +1 more source

Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis.

PLoS ONE, 2012
Mice with targeted deletion of STAT3 in CD4(+) T-cells do not develop experimental autoimmune uveitis (EAU) or experimental autoimmune encephalomyelitis (EAE), in part, because they cannot generate pathogenic Th17 cells.
Cheng-Rong Yu, Yun Sang Lee, Rashid M Mahdi, Narayanan Surendran, Charles E Egwuagu   +4 more
doaj   +1 more source

The Skewed Balance Between Tregs and Th17 in Chronic Lymphocytic Leukemia

Future Oncology, 2015
While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases.
Yousefi, Mehdi, Movassaghpour, Ali Akbar, Shamsasenjan, Karim, Ghalamfarsa, Ghasem, Sadreddini, Sanam, Jadidi-Niaragh, Farhad, Hojjat-Farsangi, Mohammad   +6 more
openaire   +4 more sources

ESTRIOL IN FUNCTIONAL MODULATION OF REGULATORY LYMPHOCYTES IN MULTIPLE SCLEROSIS

Медицинская иммунология, 2014
We studied effects of estriol (E3), at the doses corresponding to the I and III trimesters of pregnancy,upon expression of functional markers on T-regulatory (Treg) and Th17-producing (Th17) lymphocytes, aswell as the production of relevant cytokines by ...
I. V. Nekrasova, S. V. Shirshev, I. Yu. Danchenko   +2 more
doaj   +1 more source

The Th17/Treg axis: a key to understanding and treating autoimmune disorders

Open Life Sciences
In autoimmune rheumatic diseases (ARDs), T cells mistakenly attack the body’s own joints, skin, blood vessels, and other tissues, leading to chronic inflammation and tissue damage.
Xie Xiangrui, Liu Yang, Li Huijing
doaj   +1 more source

USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation

Renal Failure
Purpose This study aimed to elucidate the role of USP25 in a mouse model of anti-glomerular basement membrane glomerulonephritis (anti-GBM GN).Methods USP25-deficient anti-GBM GN mice were generated, and their nephritis progression was monitored.
Ranran Xu, Fei Huang, Qingquan Liu, Yongman Lv, Liu Hu, Qian Zhang   +5 more
doaj   +1 more source